Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling
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Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling. / Kim, Mi-Ran; Oji, Vinzenz; Valentin, Frederic; Traupe, Heiko; Nofer, Jerzy-Roch; Hausser, Ingrid; Hennies, Hans Christian; Eckl, Katja; Wudy, Stefan A; Sánchez-Guijo, Alberto; Kerschke, Laura; Fischer, Judith; Süßmuth, Kira.
In: ACTA DERM-VENEREOL, Vol. 101, No. 9, 15.09.2021, p. adv00546.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling
AU - Kim, Mi-Ran
AU - Oji, Vinzenz
AU - Valentin, Frederic
AU - Traupe, Heiko
AU - Nofer, Jerzy-Roch
AU - Hausser, Ingrid
AU - Hennies, Hans Christian
AU - Eckl, Katja
AU - Wudy, Stefan A
AU - Sánchez-Guijo, Alberto
AU - Kerschke, Laura
AU - Fischer, Judith
AU - Süßmuth, Kira
PY - 2021/9/15
Y1 - 2021/9/15
N2 - Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency.
AB - Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency.
KW - Humans
KW - Ichthyosis/diagnosis
KW - Ichthyosis, Lamellar/diagnosis
KW - Parathyroid Hormone
KW - Vitamin D
KW - Vitamin D Deficiency/diagnosis
U2 - 10.2340/00015555-3887
DO - 10.2340/00015555-3887
M3 - SCORING: Journal article
C2 - 34396419
VL - 101
SP - adv00546
JO - ACTA DERM-VENEREOL
JF - ACTA DERM-VENEREOL
SN - 0001-5555
IS - 9
ER -
