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Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PET.

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Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PET. / Krieger-Hinck, Nina; Gustke, Heike; Valentiner, Ursula; Mikecz, Pal; Buchert, Ralph; Mester, Janos; Schumacher, Udo.

In: ANTICANCER RES, Vol. 26, No. 5, 5, 2006, p. 3467-3472.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Krieger-Hinck, N, Gustke, H, Valentiner, U, Mikecz, P, Buchert, R, Mester, J & Schumacher, U 2006, 'Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PET.', ANTICANCER RES, vol. 26, no. 5, 5, pp. 3467-3472. <http://www.ncbi.nlm.nih.gov/pubmed/17094468?dopt=Citation>

APA

Krieger-Hinck, N., Gustke, H., Valentiner, U., Mikecz, P., Buchert, R., Mester, J., & Schumacher, U. (2006). Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PET. ANTICANCER RES, 26(5), 3467-3472. [5]. http://www.ncbi.nlm.nih.gov/pubmed/17094468?dopt=Citation

Vancouver

Krieger-Hinck N, Gustke H, Valentiner U, Mikecz P, Buchert R, Mester J et al. Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PET. ANTICANCER RES. 2006;26(5):3467-3472. 5.

Bibtex

@article{e74c5f4640a14220b5d14e06436b1cd1,
title = "Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PET.",
abstract = "BACKGROUND: Tumor therapy has been monitored using the metabolic indicator [18F]fluorodeoxyglucose ([18F]FDG). However, the nucleotide precursor [18F]fluoro-thymidine ([18F]FLT) is in principle more specific as it is incorporated into DNA. Thus, the [18F]FDG and [18F]FLT uptake by human neuroblastomas grown in Scid mice are compared in this study. MATERIALS AND METHODS: Scid mice were inoculated with human neuroblastoma cells. Tumor imaging was performed with a human whole-body full-ring PET scanner. Furthermore, the tumor weight and the cell proliferation rate were determined. RESULTS: Neuroblastomas could be visualised using [18F]FDG in 40% and with [18F]FLT in 70% of the cases. [18F]FDG or [18F]FLT uptake could not be visualised in neuroblastomas less than 1.0 g in weight. No correlation between the cell proliferation rate and tracer uptake could be detected. CONCLUSION: [18F]FLT showed a higher uptake than [18F]FDG and, therefore, might be more suitable for monitoring anticancer therapy, at least in this tumor model.",
author = "Nina Krieger-Hinck and Heike Gustke and Ursula Valentiner and Pal Mikecz and Ralph Buchert and Janos Mester and Udo Schumacher",
year = "2006",
language = "Deutsch",
volume = "26",
pages = "3467--3472",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Visualisation of neuroblastoma growth in a Scid mouse model using [18F]FDG and [18F]FLT-PET.

AU - Krieger-Hinck, Nina

AU - Gustke, Heike

AU - Valentiner, Ursula

AU - Mikecz, Pal

AU - Buchert, Ralph

AU - Mester, Janos

AU - Schumacher, Udo

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Tumor therapy has been monitored using the metabolic indicator [18F]fluorodeoxyglucose ([18F]FDG). However, the nucleotide precursor [18F]fluoro-thymidine ([18F]FLT) is in principle more specific as it is incorporated into DNA. Thus, the [18F]FDG and [18F]FLT uptake by human neuroblastomas grown in Scid mice are compared in this study. MATERIALS AND METHODS: Scid mice were inoculated with human neuroblastoma cells. Tumor imaging was performed with a human whole-body full-ring PET scanner. Furthermore, the tumor weight and the cell proliferation rate were determined. RESULTS: Neuroblastomas could be visualised using [18F]FDG in 40% and with [18F]FLT in 70% of the cases. [18F]FDG or [18F]FLT uptake could not be visualised in neuroblastomas less than 1.0 g in weight. No correlation between the cell proliferation rate and tracer uptake could be detected. CONCLUSION: [18F]FLT showed a higher uptake than [18F]FDG and, therefore, might be more suitable for monitoring anticancer therapy, at least in this tumor model.

AB - BACKGROUND: Tumor therapy has been monitored using the metabolic indicator [18F]fluorodeoxyglucose ([18F]FDG). However, the nucleotide precursor [18F]fluoro-thymidine ([18F]FLT) is in principle more specific as it is incorporated into DNA. Thus, the [18F]FDG and [18F]FLT uptake by human neuroblastomas grown in Scid mice are compared in this study. MATERIALS AND METHODS: Scid mice were inoculated with human neuroblastoma cells. Tumor imaging was performed with a human whole-body full-ring PET scanner. Furthermore, the tumor weight and the cell proliferation rate were determined. RESULTS: Neuroblastomas could be visualised using [18F]FDG in 40% and with [18F]FLT in 70% of the cases. [18F]FDG or [18F]FLT uptake could not be visualised in neuroblastomas less than 1.0 g in weight. No correlation between the cell proliferation rate and tracer uptake could be detected. CONCLUSION: [18F]FLT showed a higher uptake than [18F]FDG and, therefore, might be more suitable for monitoring anticancer therapy, at least in this tumor model.

M3 - SCORING: Zeitschriftenaufsatz

VL - 26

SP - 3467

EP - 3472

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 5

M1 - 5

ER -