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Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke

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Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke. / Hermitte, Laure; Cho, Tae-Hee; Ozenne, Brice; Nighoghossian, Norbert; Mikkelsen, Irene Klærke; Ribe, Lars; Baron, Jean-Claude; Østergaard, Leif; Derex, Laurent; Hjort, Niels; Fiehler, Jens; Pedraza, Salvador; Hermier, Marc; Maucort-Boulch, Delphine; Berthezène, Yves.

In: STROKE, Vol. 44, No. 8, 01.08.2013, p. 2318-20.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hermitte, L, Cho, T-H, Ozenne, B, Nighoghossian, N, Mikkelsen, IK, Ribe, L, Baron, J-C, Østergaard, L, Derex, L, Hjort, N, Fiehler, J, Pedraza, S, Hermier, M, Maucort-Boulch, D & Berthezène, Y 2013, 'Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke', STROKE, vol. 44, no. 8, pp. 2318-20. https://doi.org/10.1161/STROKEAHA.113.001751

APA

Hermitte, L., Cho, T-H., Ozenne, B., Nighoghossian, N., Mikkelsen, I. K., Ribe, L., Baron, J-C., Østergaard, L., Derex, L., Hjort, N., Fiehler, J., Pedraza, S., Hermier, M., Maucort-Boulch, D., & Berthezène, Y. (2013). Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke. STROKE, 44(8), 2318-20. https://doi.org/10.1161/STROKEAHA.113.001751

Vancouver

Hermitte L, Cho T-H, Ozenne B, Nighoghossian N, Mikkelsen IK, Ribe L et al. Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke. STROKE. 2013 Aug 1;44(8):2318-20. https://doi.org/10.1161/STROKEAHA.113.001751

Bibtex

@article{b3ff2d98b8f5482ea4b609da922d4f7b,
title = "Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke",
abstract = "BACKGROUND AND PURPOSE: Parenchymal hematoma (PH) may worsen the outcome of patients with stroke. The aim of our study was to confirm the relationship between the volume of very low cerebral blood volume (CBV) and PH using a European multicenter database (I-KNOW). A secondary objective was to explore the impact of early reperfusion and recanalization.METHODS: The volume of cerebral tissue with CBV≤2.5th percentile of the normal hemisphere was calculated within the acute diffusion-weighted imaging lesion. Hemorrhagic transformation was assessed on day 2 MRI according to the European Cooperative Acute Stroke Study II criteria. Recanalization and reperfusion were assessed on 3-hour follow-up MRI.RESULTS: Of the 110 patients, hemorrhagic transformation occurred in 59 patients, including 7 PH. In univariate analysis, the acute National Institutes of Health Stroke Scale score (P=0.002), acute diffusion-weighted imaging lesion volume (P=0.02), and thrombolysis (P=0.03), but not very low CBV (P=0.52), were associated with hemorrhagic transformation. The volume of very low CBV was the only predictor of PH (P=0.007). Early reperfusion and recanalization had no influence on either hemorrhagic transformation or PH.CONCLUSION: Very low CBV was the only independent predictor of PH in patients with acute stroke.",
keywords = "Acute Disease, Aged, Aged, 80 and over, Blood Volume, Brain Ischemia, Cerebrovascular Circulation, Cohort Studies, Diffusion Magnetic Resonance Imaging, Europe, Female, Hematoma, Humans, Male, Middle Aged, Predictive Value of Tests, Registries, Reperfusion, Severity of Illness Index, Stroke, Time Factors, Treatment Outcome",
author = "Laure Hermitte and Tae-Hee Cho and Brice Ozenne and Norbert Nighoghossian and Mikkelsen, {Irene Kl{\ae}rke} and Lars Ribe and Jean-Claude Baron and Leif {\O}stergaard and Laurent Derex and Niels Hjort and Jens Fiehler and Salvador Pedraza and Marc Hermier and Delphine Maucort-Boulch and Yves Berthez{\`e}ne",
year = "2013",
month = aug,
day = "1",
doi = "10.1161/STROKEAHA.113.001751",
language = "English",
volume = "44",
pages = "2318--20",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Very low cerebral blood volume predicts parenchymal hematoma in acute ischemic stroke

AU - Hermitte, Laure

AU - Cho, Tae-Hee

AU - Ozenne, Brice

AU - Nighoghossian, Norbert

AU - Mikkelsen, Irene Klærke

AU - Ribe, Lars

AU - Baron, Jean-Claude

AU - Østergaard, Leif

AU - Derex, Laurent

AU - Hjort, Niels

AU - Fiehler, Jens

AU - Pedraza, Salvador

AU - Hermier, Marc

AU - Maucort-Boulch, Delphine

AU - Berthezène, Yves

PY - 2013/8/1

Y1 - 2013/8/1

N2 - BACKGROUND AND PURPOSE: Parenchymal hematoma (PH) may worsen the outcome of patients with stroke. The aim of our study was to confirm the relationship between the volume of very low cerebral blood volume (CBV) and PH using a European multicenter database (I-KNOW). A secondary objective was to explore the impact of early reperfusion and recanalization.METHODS: The volume of cerebral tissue with CBV≤2.5th percentile of the normal hemisphere was calculated within the acute diffusion-weighted imaging lesion. Hemorrhagic transformation was assessed on day 2 MRI according to the European Cooperative Acute Stroke Study II criteria. Recanalization and reperfusion were assessed on 3-hour follow-up MRI.RESULTS: Of the 110 patients, hemorrhagic transformation occurred in 59 patients, including 7 PH. In univariate analysis, the acute National Institutes of Health Stroke Scale score (P=0.002), acute diffusion-weighted imaging lesion volume (P=0.02), and thrombolysis (P=0.03), but not very low CBV (P=0.52), were associated with hemorrhagic transformation. The volume of very low CBV was the only predictor of PH (P=0.007). Early reperfusion and recanalization had no influence on either hemorrhagic transformation or PH.CONCLUSION: Very low CBV was the only independent predictor of PH in patients with acute stroke.

AB - BACKGROUND AND PURPOSE: Parenchymal hematoma (PH) may worsen the outcome of patients with stroke. The aim of our study was to confirm the relationship between the volume of very low cerebral blood volume (CBV) and PH using a European multicenter database (I-KNOW). A secondary objective was to explore the impact of early reperfusion and recanalization.METHODS: The volume of cerebral tissue with CBV≤2.5th percentile of the normal hemisphere was calculated within the acute diffusion-weighted imaging lesion. Hemorrhagic transformation was assessed on day 2 MRI according to the European Cooperative Acute Stroke Study II criteria. Recanalization and reperfusion were assessed on 3-hour follow-up MRI.RESULTS: Of the 110 patients, hemorrhagic transformation occurred in 59 patients, including 7 PH. In univariate analysis, the acute National Institutes of Health Stroke Scale score (P=0.002), acute diffusion-weighted imaging lesion volume (P=0.02), and thrombolysis (P=0.03), but not very low CBV (P=0.52), were associated with hemorrhagic transformation. The volume of very low CBV was the only predictor of PH (P=0.007). Early reperfusion and recanalization had no influence on either hemorrhagic transformation or PH.CONCLUSION: Very low CBV was the only independent predictor of PH in patients with acute stroke.

KW - Acute Disease

KW - Aged

KW - Aged, 80 and over

KW - Blood Volume

KW - Brain Ischemia

KW - Cerebrovascular Circulation

KW - Cohort Studies

KW - Diffusion Magnetic Resonance Imaging

KW - Europe

KW - Female

KW - Hematoma

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Registries

KW - Reperfusion

KW - Severity of Illness Index

KW - Stroke

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1161/STROKEAHA.113.001751

DO - 10.1161/STROKEAHA.113.001751

M3 - SCORING: Journal article

C2 - 23723309

VL - 44

SP - 2318

EP - 2320

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 8

ER -