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Ventricular conduction abnormalities as predictors of long-term survival in acute de novo and decompensated chronic heart failure

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Ventricular conduction abnormalities as predictors of long-term survival in acute de novo and decompensated chronic heart failure. / Tolppanen, Heli; Siirila-Waris, Krista; Harjola, Veli-Pekka; Marono, David; Parenica, Jiri; Kreutzinger, Philipp; Nieminen, Tuomo; Pavlusova, Marie; Tarvasmaki, Tuukka; Twerenbold, Raphael; Tolonen, Jukka; Miklik, Roman; Nieminen, Markku S; Spinar, Jindrich; Mueller, Christian; Lassus, Johan.

In: ESC HEART FAIL, Vol. 3, No. 1, 03.2016, p. 35-43.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tolppanen, H, Siirila-Waris, K, Harjola, V-P, Marono, D, Parenica, J, Kreutzinger, P, Nieminen, T, Pavlusova, M, Tarvasmaki, T, Twerenbold, R, Tolonen, J, Miklik, R, Nieminen, MS, Spinar, J, Mueller, C & Lassus, J 2016, 'Ventricular conduction abnormalities as predictors of long-term survival in acute de novo and decompensated chronic heart failure', ESC HEART FAIL, vol. 3, no. 1, pp. 35-43. https://doi.org/10.1002/ehf2.12068

APA

Tolppanen, H., Siirila-Waris, K., Harjola, V-P., Marono, D., Parenica, J., Kreutzinger, P., Nieminen, T., Pavlusova, M., Tarvasmaki, T., Twerenbold, R., Tolonen, J., Miklik, R., Nieminen, M. S., Spinar, J., Mueller, C., & Lassus, J. (2016). Ventricular conduction abnormalities as predictors of long-term survival in acute de novo and decompensated chronic heart failure. ESC HEART FAIL, 3(1), 35-43. https://doi.org/10.1002/ehf2.12068

Vancouver

Tolppanen H, Siirila-Waris K, Harjola V-P, Marono D, Parenica J, Kreutzinger P et al. Ventricular conduction abnormalities as predictors of long-term survival in acute de novo and decompensated chronic heart failure. ESC HEART FAIL. 2016 Mar;3(1):35-43. https://doi.org/10.1002/ehf2.12068

Bibtex

@article{10382c28b2ba4e398c743c096f66d671,
title = "Ventricular conduction abnormalities as predictors of long-term survival in acute de novo and decompensated chronic heart failure",
abstract = "AIMS: Data on the prognostic role of left and right bundle branch blocks (LBBB and RBBB), and nonspecific intraventricular conduction delay (IVCD; QRS ≥ 110 ms, no BBB) in acute heart failure (AHF) are controversial. Our aim was to investigate electrocardiographic predictors of long-term survival in patients with de novo AHF and acutely decompensated chronic heart failure (ADCHF).METHODS AND RESULTS: We analysed the admission electrocardiogram of 982 patients from a multicenter European cohort of AHF with 3.9 years' mean follow-up. Half (51.5%, n = 506) of the patients had de novo AHF. LBBB, and IVCD were more common in ADCHF than in de novo AHF: 17.2% vs. 8.7% (P < 0.001) and 20.6% vs. 13.2% (P = 0.001), respectively, and RBBB was almost equally common (6.9% and 8.1%; P = 0.5), respectively. Mortality during the follow-up was higher in patients with RBBB (85.4%) and IVCD (73.7%) compared with patients with normal ventricular conduction (57.0%); P < 0.001 for both. The impact of RBBB on prognosis was prominent in de novo AHF (adjusted HR 1.93, 1.03-3.60; P = 0.04), and IVCD independently predicted death in ADCHF (adjusted HR 1.79, 1.28-2.52; P = 0.001). Both findings were pronounced in patients with reduced ejection fraction. LBBB showed no association with increased mortality in either of the subgroups. The main results were confirmed in a validation cohort of 1511 AHF patients with 5.9 years' mean follow-up.CONCLUSIONS: Conduction abnormalities predict long-term survival differently in de novo AHF and ADCHF. RBBB predicts mortality in de novo AHF, and IVCD in ADCHF. LBBB has no additive predictive value in AHF requiring hospitalization.",
author = "Heli Tolppanen and Krista Siirila-Waris and Veli-Pekka Harjola and David Marono and Jiri Parenica and Philipp Kreutzinger and Tuomo Nieminen and Marie Pavlusova and Tuukka Tarvasmaki and Raphael Twerenbold and Jukka Tolonen and Roman Miklik and Nieminen, {Markku S} and Jindrich Spinar and Christian Mueller and Johan Lassus",
year = "2016",
month = mar,
doi = "10.1002/ehf2.12068",
language = "English",
volume = "3",
pages = "35--43",
journal = "ESC HEART FAIL",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "1",

}

RIS

TY - JOUR

T1 - Ventricular conduction abnormalities as predictors of long-term survival in acute de novo and decompensated chronic heart failure

AU - Tolppanen, Heli

AU - Siirila-Waris, Krista

AU - Harjola, Veli-Pekka

AU - Marono, David

AU - Parenica, Jiri

AU - Kreutzinger, Philipp

AU - Nieminen, Tuomo

AU - Pavlusova, Marie

AU - Tarvasmaki, Tuukka

AU - Twerenbold, Raphael

AU - Tolonen, Jukka

AU - Miklik, Roman

AU - Nieminen, Markku S

AU - Spinar, Jindrich

AU - Mueller, Christian

AU - Lassus, Johan

PY - 2016/3

Y1 - 2016/3

N2 - AIMS: Data on the prognostic role of left and right bundle branch blocks (LBBB and RBBB), and nonspecific intraventricular conduction delay (IVCD; QRS ≥ 110 ms, no BBB) in acute heart failure (AHF) are controversial. Our aim was to investigate electrocardiographic predictors of long-term survival in patients with de novo AHF and acutely decompensated chronic heart failure (ADCHF).METHODS AND RESULTS: We analysed the admission electrocardiogram of 982 patients from a multicenter European cohort of AHF with 3.9 years' mean follow-up. Half (51.5%, n = 506) of the patients had de novo AHF. LBBB, and IVCD were more common in ADCHF than in de novo AHF: 17.2% vs. 8.7% (P < 0.001) and 20.6% vs. 13.2% (P = 0.001), respectively, and RBBB was almost equally common (6.9% and 8.1%; P = 0.5), respectively. Mortality during the follow-up was higher in patients with RBBB (85.4%) and IVCD (73.7%) compared with patients with normal ventricular conduction (57.0%); P < 0.001 for both. The impact of RBBB on prognosis was prominent in de novo AHF (adjusted HR 1.93, 1.03-3.60; P = 0.04), and IVCD independently predicted death in ADCHF (adjusted HR 1.79, 1.28-2.52; P = 0.001). Both findings were pronounced in patients with reduced ejection fraction. LBBB showed no association with increased mortality in either of the subgroups. The main results were confirmed in a validation cohort of 1511 AHF patients with 5.9 years' mean follow-up.CONCLUSIONS: Conduction abnormalities predict long-term survival differently in de novo AHF and ADCHF. RBBB predicts mortality in de novo AHF, and IVCD in ADCHF. LBBB has no additive predictive value in AHF requiring hospitalization.

AB - AIMS: Data on the prognostic role of left and right bundle branch blocks (LBBB and RBBB), and nonspecific intraventricular conduction delay (IVCD; QRS ≥ 110 ms, no BBB) in acute heart failure (AHF) are controversial. Our aim was to investigate electrocardiographic predictors of long-term survival in patients with de novo AHF and acutely decompensated chronic heart failure (ADCHF).METHODS AND RESULTS: We analysed the admission electrocardiogram of 982 patients from a multicenter European cohort of AHF with 3.9 years' mean follow-up. Half (51.5%, n = 506) of the patients had de novo AHF. LBBB, and IVCD were more common in ADCHF than in de novo AHF: 17.2% vs. 8.7% (P < 0.001) and 20.6% vs. 13.2% (P = 0.001), respectively, and RBBB was almost equally common (6.9% and 8.1%; P = 0.5), respectively. Mortality during the follow-up was higher in patients with RBBB (85.4%) and IVCD (73.7%) compared with patients with normal ventricular conduction (57.0%); P < 0.001 for both. The impact of RBBB on prognosis was prominent in de novo AHF (adjusted HR 1.93, 1.03-3.60; P = 0.04), and IVCD independently predicted death in ADCHF (adjusted HR 1.79, 1.28-2.52; P = 0.001). Both findings were pronounced in patients with reduced ejection fraction. LBBB showed no association with increased mortality in either of the subgroups. The main results were confirmed in a validation cohort of 1511 AHF patients with 5.9 years' mean follow-up.CONCLUSIONS: Conduction abnormalities predict long-term survival differently in de novo AHF and ADCHF. RBBB predicts mortality in de novo AHF, and IVCD in ADCHF. LBBB has no additive predictive value in AHF requiring hospitalization.

U2 - 10.1002/ehf2.12068

DO - 10.1002/ehf2.12068

M3 - SCORING: Journal article

C2 - 27774265

VL - 3

SP - 35

EP - 43

JO - ESC HEART FAIL

JF - ESC HEART FAIL

SN - 2055-5822

IS - 1

ER -