Ventral striatal signal changes represent missed opportunities and predict future choice.
Standard
Ventral striatal signal changes represent missed opportunities and predict future choice. / Büchel, Christian; Brassen, Stefanie; Yacubian, Juliana; Kalisch, Raffael; Sommer-Blöchl, Tobias.
In: NEUROIMAGE, Vol. 57, No. 3, 3, 2011, p. 1124-1130.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Ventral striatal signal changes represent missed opportunities and predict future choice.
AU - Büchel, Christian
AU - Brassen, Stefanie
AU - Yacubian, Juliana
AU - Kalisch, Raffael
AU - Sommer-Blöchl, Tobias
PY - 2011
Y1 - 2011
N2 - Realizing one has missed an opportunity can influence decision behavior in the future, such that a large missed opportunity leads to more risk taking in the next round. To investigate the neuronal mechanism of this phenomenon we used functional magnetic resonance imaging (fMRI) in combination with a sequential decision task in which the magnitude of possible gains linearly increased, but at the same time the gain probability decreased. After subjects decided to stop a trial and to collect the gains, not only the chosen option (actual outcome), but also the alternative option (maximum possible gain in this round) was revealed. Our data show that a missed chance influenced volunteers' decision behavior: volunteers took more risk after rounds in which they had missed a large opportunity. This was paralleled by signal changes in a lateral area of the ventral striatum that scaled with the difference between what could have been gained and what was actually gained in this round. In addition, after gains signal changes in dopaminoceptive structures including the midbrain and ventral striatum together with the insula predicted individual choice behavior in the subsequent round. Thus, our data provide a neural mechanism for how missed opportunities influence future decisions.
AB - Realizing one has missed an opportunity can influence decision behavior in the future, such that a large missed opportunity leads to more risk taking in the next round. To investigate the neuronal mechanism of this phenomenon we used functional magnetic resonance imaging (fMRI) in combination with a sequential decision task in which the magnitude of possible gains linearly increased, but at the same time the gain probability decreased. After subjects decided to stop a trial and to collect the gains, not only the chosen option (actual outcome), but also the alternative option (maximum possible gain in this round) was revealed. Our data show that a missed chance influenced volunteers' decision behavior: volunteers took more risk after rounds in which they had missed a large opportunity. This was paralleled by signal changes in a lateral area of the ventral striatum that scaled with the difference between what could have been gained and what was actually gained in this round. In addition, after gains signal changes in dopaminoceptive structures including the midbrain and ventral striatum together with the insula predicted individual choice behavior in the subsequent round. Thus, our data provide a neural mechanism for how missed opportunities influence future decisions.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Magnetic Resonance Imaging
KW - Image Interpretation, Computer-Assisted
KW - Brain Mapping
KW - Basal Ganglia/physiology
KW - Choice Behavior/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Magnetic Resonance Imaging
KW - Image Interpretation, Computer-Assisted
KW - Brain Mapping
KW - Basal Ganglia/physiology
KW - Choice Behavior/physiology
M3 - SCORING: Journal article
VL - 57
SP - 1124
EP - 1130
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
IS - 3
M1 - 3
ER -
