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Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

Standard

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency. / Wang, Dong; Tediashvili, Grigol; Pecha, Simon; Reichenspurner, Hermann; Deuse, Tobias; Schrepfer, Sonja.

In: JOVE-J VIS EXP, No. 119, 15.01.2017.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wang, D, Tediashvili, G, Pecha, S, Reichenspurner, H, Deuse, T & Schrepfer, S 2017, 'Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency', JOVE-J VIS EXP, no. 119. https://doi.org/10.3791/54839

APA

Wang, D., Tediashvili, G., Pecha, S., Reichenspurner, H., Deuse, T., & Schrepfer, S. (2017). Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency. JOVE-J VIS EXP, (119). https://doi.org/10.3791/54839

Vancouver

Wang D, Tediashvili G, Pecha S, Reichenspurner H, Deuse T, Schrepfer S. Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency. JOVE-J VIS EXP. 2017 Jan 15;(119). https://doi.org/10.3791/54839

Bibtex

@article{0269f3215d33496cabae50405f543a1a,
title = "Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency",
abstract = "Bypass grafting is an established treatment method for coronary artery disease. Graft patency continues to be the Achilles heel of saphenous vein grafts. Research models for bypass graft failure are essential for a better understanding of pathobiological and pathophysiological processes during graft patency loss. Large animal models, such as pigs or sheep, resemble human anatomical structures but require special facilities and equipment. This video describes a rat vein interposition model to investigate vein graft patency loss. Rats are inexpensive and easy to handle. Compared to mouse models, the convenient size of rats permits better operability and enables a sufficient amount of material to be obtained for further diverse analysis. In brief, the inferior epigastric vein of a donor rat is harvested and used to replace a segment of the femoral artery. Anastomosis is conducted via single stitches and sealed with fibrin glue. Graft patency can be monitored non-invasively using duplex sonography. Myointimal hyperplasia, which is the main cause for graft patency loss, develops progressively over time and can be calculated from histological cross sections.",
keywords = "Anastomosis, Surgical, Animals, Coronary Artery Disease/surgery, Femoral Artery/surgery, Models, Animal, Rats, Saphenous Vein/surgery, Vascular Grafting/methods, Vascular Patency",
author = "Dong Wang and Grigol Tediashvili and Simon Pecha and Hermann Reichenspurner and Tobias Deuse and Sonja Schrepfer",
year = "2017",
month = jan,
day = "15",
doi = "10.3791/54839",
language = "English",
journal = "JOVE-J VIS EXP",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "119",

}

RIS

TY - JOUR

T1 - Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

AU - Wang, Dong

AU - Tediashvili, Grigol

AU - Pecha, Simon

AU - Reichenspurner, Hermann

AU - Deuse, Tobias

AU - Schrepfer, Sonja

PY - 2017/1/15

Y1 - 2017/1/15

N2 - Bypass grafting is an established treatment method for coronary artery disease. Graft patency continues to be the Achilles heel of saphenous vein grafts. Research models for bypass graft failure are essential for a better understanding of pathobiological and pathophysiological processes during graft patency loss. Large animal models, such as pigs or sheep, resemble human anatomical structures but require special facilities and equipment. This video describes a rat vein interposition model to investigate vein graft patency loss. Rats are inexpensive and easy to handle. Compared to mouse models, the convenient size of rats permits better operability and enables a sufficient amount of material to be obtained for further diverse analysis. In brief, the inferior epigastric vein of a donor rat is harvested and used to replace a segment of the femoral artery. Anastomosis is conducted via single stitches and sealed with fibrin glue. Graft patency can be monitored non-invasively using duplex sonography. Myointimal hyperplasia, which is the main cause for graft patency loss, develops progressively over time and can be calculated from histological cross sections.

AB - Bypass grafting is an established treatment method for coronary artery disease. Graft patency continues to be the Achilles heel of saphenous vein grafts. Research models for bypass graft failure are essential for a better understanding of pathobiological and pathophysiological processes during graft patency loss. Large animal models, such as pigs or sheep, resemble human anatomical structures but require special facilities and equipment. This video describes a rat vein interposition model to investigate vein graft patency loss. Rats are inexpensive and easy to handle. Compared to mouse models, the convenient size of rats permits better operability and enables a sufficient amount of material to be obtained for further diverse analysis. In brief, the inferior epigastric vein of a donor rat is harvested and used to replace a segment of the femoral artery. Anastomosis is conducted via single stitches and sealed with fibrin glue. Graft patency can be monitored non-invasively using duplex sonography. Myointimal hyperplasia, which is the main cause for graft patency loss, develops progressively over time and can be calculated from histological cross sections.

KW - Anastomosis, Surgical

KW - Animals

KW - Coronary Artery Disease/surgery

KW - Femoral Artery/surgery

KW - Models, Animal

KW - Rats

KW - Saphenous Vein/surgery

KW - Vascular Grafting/methods

KW - Vascular Patency

U2 - 10.3791/54839

DO - 10.3791/54839

M3 - SCORING: Journal article

C2 - 28117809

JO - JOVE-J VIS EXP

JF - JOVE-J VIS EXP

SN - 1940-087X

IS - 119

ER -