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VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma

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VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma. / Uzunoglu, F G; Kolbe, J; Wikman, Harriet; Güngör, C; Bohn, B A; Nentwich, M F; Reeh, M; König, A M; Bockhorn, M; Kutup, A; Mann, O; Izbicki, J R; Vashist, Y K.

In: ANN ONCOL, Vol. 24, No. 5, 01.05.2013, p. 1282-90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Uzunoglu, FG, Kolbe, J, Wikman, H, Güngör, C, Bohn, BA, Nentwich, MF, Reeh, M, König, AM, Bockhorn, M, Kutup, A, Mann, O, Izbicki, JR & Vashist, YK 2013, 'VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma', ANN ONCOL, vol. 24, no. 5, pp. 1282-90. https://doi.org/10.1093/annonc/mds634

APA

Uzunoglu, F. G., Kolbe, J., Wikman, H., Güngör, C., Bohn, B. A., Nentwich, M. F., Reeh, M., König, A. M., Bockhorn, M., Kutup, A., Mann, O., Izbicki, J. R., & Vashist, Y. K. (2013). VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma. ANN ONCOL, 24(5), 1282-90. https://doi.org/10.1093/annonc/mds634

Vancouver

Uzunoglu FG, Kolbe J, Wikman H, Güngör C, Bohn BA, Nentwich MF et al. VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma. ANN ONCOL. 2013 May 1;24(5):1282-90. https://doi.org/10.1093/annonc/mds634

Bibtex

@article{e005c97b9deb4c45ade2bef6f96ddf3e,
title = "VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma",
abstract = "BACKGROUND: Hypoxic environment of pancreatic cancer (PC) implicates high vascular in-growth, which may be influenced by angiogenesis-related germline polymorphisms. Our purpose was to evaluate polymorphisms of vascular endothelial growth factor receptor 2 (VEGFR-2), CXC chemokine receptor 2 (CXCR-2), proteinase-activated receptor 1 (PAR-1) and endostatin (ES) as prognostic markers for disease-free (DFS) and overall survival (OS) in PC.PATIENTS AND METHODS: Genotyping of 173 patients, surgically treated for PC between 2004 and 2011, was carried out by TaqMan({\textregistered}) genotyping assays or polymerase chain reaction. Chi-square test, Kaplan-Meier estimator and Cox regression hazard model were used to assess the prognostic value of selected polymorphisms.RESULTS: VEGFR-2 -906 T/T and PAR-1 -506 Del/Del genotypes predicted longer DFS (P = 0.003, P = 0.014) and OS (VEGFR-2 -906, P = 0.011). CXCR-2 +1208 T/T genotype was a negative predictor for DFS (P < 0.0001). Combined analysis for DFS and OS indicated that patients with the fewest number of favorable genotypes simultaneously present (VEGFR-2 -906 T/T, CXCR-2 +1208 C/T or C/C and PAR-1 -506 Del/Del) were at the highest risk for recurrence or death (P < 0.0001).CONCLUSION: VEGFR-2 -906 C>T, CXCR-2 +1208 C>T and PAR-1 -506 Ins/Del polymorphisms are potential predictors for survival in PC.",
keywords = "Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Genotype, Humans, Male, Middle Aged, Neovascularization, Pathologic, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Receptor, PAR-1, Receptors, Interleukin-8B, Survival, Tumor Markers, Biological, Vascular Endothelial Growth Factor Receptor-2",
author = "Uzunoglu, {F G} and J Kolbe and Harriet Wikman and C G{\"u}ng{\"o}r and Bohn, {B A} and Nentwich, {M F} and M Reeh and K{\"o}nig, {A M} and M Bockhorn and A Kutup and O Mann and Izbicki, {J R} and Vashist, {Y K}",
year = "2013",
month = may,
day = "1",
doi = "10.1093/annonc/mds634",
language = "English",
volume = "24",
pages = "1282--90",
journal = "ANN ONCOL",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma

AU - Uzunoglu, F G

AU - Kolbe, J

AU - Wikman, Harriet

AU - Güngör, C

AU - Bohn, B A

AU - Nentwich, M F

AU - Reeh, M

AU - König, A M

AU - Bockhorn, M

AU - Kutup, A

AU - Mann, O

AU - Izbicki, J R

AU - Vashist, Y K

PY - 2013/5/1

Y1 - 2013/5/1

N2 - BACKGROUND: Hypoxic environment of pancreatic cancer (PC) implicates high vascular in-growth, which may be influenced by angiogenesis-related germline polymorphisms. Our purpose was to evaluate polymorphisms of vascular endothelial growth factor receptor 2 (VEGFR-2), CXC chemokine receptor 2 (CXCR-2), proteinase-activated receptor 1 (PAR-1) and endostatin (ES) as prognostic markers for disease-free (DFS) and overall survival (OS) in PC.PATIENTS AND METHODS: Genotyping of 173 patients, surgically treated for PC between 2004 and 2011, was carried out by TaqMan(®) genotyping assays or polymerase chain reaction. Chi-square test, Kaplan-Meier estimator and Cox regression hazard model were used to assess the prognostic value of selected polymorphisms.RESULTS: VEGFR-2 -906 T/T and PAR-1 -506 Del/Del genotypes predicted longer DFS (P = 0.003, P = 0.014) and OS (VEGFR-2 -906, P = 0.011). CXCR-2 +1208 T/T genotype was a negative predictor for DFS (P < 0.0001). Combined analysis for DFS and OS indicated that patients with the fewest number of favorable genotypes simultaneously present (VEGFR-2 -906 T/T, CXCR-2 +1208 C/T or C/C and PAR-1 -506 Del/Del) were at the highest risk for recurrence or death (P < 0.0001).CONCLUSION: VEGFR-2 -906 C>T, CXCR-2 +1208 C>T and PAR-1 -506 Ins/Del polymorphisms are potential predictors for survival in PC.

AB - BACKGROUND: Hypoxic environment of pancreatic cancer (PC) implicates high vascular in-growth, which may be influenced by angiogenesis-related germline polymorphisms. Our purpose was to evaluate polymorphisms of vascular endothelial growth factor receptor 2 (VEGFR-2), CXC chemokine receptor 2 (CXCR-2), proteinase-activated receptor 1 (PAR-1) and endostatin (ES) as prognostic markers for disease-free (DFS) and overall survival (OS) in PC.PATIENTS AND METHODS: Genotyping of 173 patients, surgically treated for PC between 2004 and 2011, was carried out by TaqMan(®) genotyping assays or polymerase chain reaction. Chi-square test, Kaplan-Meier estimator and Cox regression hazard model were used to assess the prognostic value of selected polymorphisms.RESULTS: VEGFR-2 -906 T/T and PAR-1 -506 Del/Del genotypes predicted longer DFS (P = 0.003, P = 0.014) and OS (VEGFR-2 -906, P = 0.011). CXCR-2 +1208 T/T genotype was a negative predictor for DFS (P < 0.0001). Combined analysis for DFS and OS indicated that patients with the fewest number of favorable genotypes simultaneously present (VEGFR-2 -906 T/T, CXCR-2 +1208 C/T or C/C and PAR-1 -506 Del/Del) were at the highest risk for recurrence or death (P < 0.0001).CONCLUSION: VEGFR-2 -906 C>T, CXCR-2 +1208 C>T and PAR-1 -506 Ins/Del polymorphisms are potential predictors for survival in PC.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Neovascularization, Pathologic

KW - Pancreatic Neoplasms

KW - Polymorphism, Single Nucleotide

KW - Receptor, PAR-1

KW - Receptors, Interleukin-8B

KW - Survival

KW - Tumor Markers, Biological

KW - Vascular Endothelial Growth Factor Receptor-2

U2 - 10.1093/annonc/mds634

DO - 10.1093/annonc/mds634

M3 - SCORING: Journal article

C2 - 23293110

VL - 24

SP - 1282

EP - 1290

JO - ANN ONCOL

JF - ANN ONCOL

SN - 0923-7534

IS - 5

ER -