Vascular-Metabolic Risk Factors and Psychological Stress in Patients with Chronic Tinnitus
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Vascular-Metabolic Risk Factors and Psychological Stress in Patients with Chronic Tinnitus. / Boecking, Benjamin; Klasing, Sven; Walter, Michael; Brueggemann, Petra; Nyamaa, Amarjargal; Rose, Matthias; Mazurek, Birgit.
In: NUTRIENTS, Vol. 14, No. 11, 2256, 28.05.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Vascular-Metabolic Risk Factors and Psychological Stress in Patients with Chronic Tinnitus
AU - Boecking, Benjamin
AU - Klasing, Sven
AU - Walter, Michael
AU - Brueggemann, Petra
AU - Nyamaa, Amarjargal
AU - Rose, Matthias
AU - Mazurek, Birgit
PY - 2022/5/28
Y1 - 2022/5/28
N2 - Little is known about molecular correlates of chronic tinnitus. We examined interrelationships between vascular−metabolic risk factors, perceived stress, and other routine blood values in patients with chronic tinnitus. Two-hundred patients (51% female) were screened for 49 blood parameters pertaining to vascular−metabolic risk, immune function, and redox processes. They further completed perceived stress- and tinnitus-related distress questionnaires. Following descriptive analyses, gender-specific sets of age- and tinnitus-severity-adjusted regression models investigated associations between perceived stress and blood parameters. Patients reported mildly elevated levels of perceived stress. Elevated levels of total cholesterol (65% and 61% of female and male patients, respectively), non-HDL-c (43/50%), LDL-c (56/59%), and lipoprotein_a (28/14%) were accompanied by high rates of overweight (99/100%) and smoking (28/31%). A low-level inflammatory state was accompanied by reduced reactive oxygen species (ROS)-neutralizing capacity (reduced co-enzyme Q10 and SOD1 levels). Most vascular risk factors were not correlated with perceived stress, except for fibrinogen (ß = −0.34) as well as C-reactive protein (ß = −0.31, p < 0.05) in men, and MCV (ß = −0.26, p < 0.05) in women. Interrelations between blood parameters and stress levels need to be investigated within psychobehavioural frameworks across varying distress levels. Alongside psychological interventions, a low-level inflammatory state may be a route for pharmacological therapeutics.
AB - Little is known about molecular correlates of chronic tinnitus. We examined interrelationships between vascular−metabolic risk factors, perceived stress, and other routine blood values in patients with chronic tinnitus. Two-hundred patients (51% female) were screened for 49 blood parameters pertaining to vascular−metabolic risk, immune function, and redox processes. They further completed perceived stress- and tinnitus-related distress questionnaires. Following descriptive analyses, gender-specific sets of age- and tinnitus-severity-adjusted regression models investigated associations between perceived stress and blood parameters. Patients reported mildly elevated levels of perceived stress. Elevated levels of total cholesterol (65% and 61% of female and male patients, respectively), non-HDL-c (43/50%), LDL-c (56/59%), and lipoprotein_a (28/14%) were accompanied by high rates of overweight (99/100%) and smoking (28/31%). A low-level inflammatory state was accompanied by reduced reactive oxygen species (ROS)-neutralizing capacity (reduced co-enzyme Q10 and SOD1 levels). Most vascular risk factors were not correlated with perceived stress, except for fibrinogen (ß = −0.34) as well as C-reactive protein (ß = −0.31, p < 0.05) in men, and MCV (ß = −0.26, p < 0.05) in women. Interrelations between blood parameters and stress levels need to be investigated within psychobehavioural frameworks across varying distress levels. Alongside psychological interventions, a low-level inflammatory state may be a route for pharmacological therapeutics.
KW - Female
KW - Humans
KW - Male
KW - Risk Factors
KW - Stress, Psychological/psychology
KW - Surveys and Questionnaires
KW - Tinnitus/epidemiology
U2 - 10.3390/nu14112256
DO - 10.3390/nu14112256
M3 - SCORING: Journal article
C2 - 35684056
VL - 14
JO - NUTRIENTS
JF - NUTRIENTS
SN - 2072-6643
IS - 11
M1 - 2256
ER -