Variations in PPARD determine the change in body composition during lifestyle intervention
Standard
Variations in PPARD determine the change in body composition during lifestyle intervention : a whole-body magnetic resonance study. / Thamer, Claus; Machann, Jürgen; Stefan, Norbert; Schäfer, Silke A; Machicao, Fausto; Staiger, Harald; Laakso, Markku; Böttcher, Michael; Claussen, Claus; Schick, Fritz; Fritsche, Andreas; Haring, Hans-Ulrich.
In: J CLIN ENDOCR METAB, Vol. 93, No. 4, 01.04.2008, p. 1497-500.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Variations in PPARD determine the change in body composition during lifestyle intervention
T2 - a whole-body magnetic resonance study
AU - Thamer, Claus
AU - Machann, Jürgen
AU - Stefan, Norbert
AU - Schäfer, Silke A
AU - Machicao, Fausto
AU - Staiger, Harald
AU - Laakso, Markku
AU - Böttcher, Michael
AU - Claussen, Claus
AU - Schick, Fritz
AU - Fritsche, Andreas
AU - Haring, Hans-Ulrich
PY - 2008/4/1
Y1 - 2008/4/1
N2 - CONTEXT: We recently demonstrated that single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-delta gene (PPARD), i.e. rs1053049, rs6902123, and rs2267668, affect the improvement of mitochondrial function, aerobic physical fitness, and insulin sensitivity by lifestyle intervention (LI).OBJECTIVE: The objective of the study was to determine whether the aforementioned PPARD SNPs influence the change in body composition and ectopic fat storage during LI.DESIGN: A total of 156 subjects at an increased risk for type 2 diabetes were genotyped for rs1053049, rs6902123, and rs2267668 and participated in a LI program. Body fat depots, ectopic liver fat, and muscle volume of the leg were quantified using magnetic resonance spectroscopy and imaging.RESULTS: With regard to body composition, carriers of the minor SNP alleles displayed reduced responses to LI, i.e. LI-induced reduction in adipose tissue mass (nonvisceral adipose tissue: rs1053049, P = 0.02; rs2267668, P = 0.04; visceral adipose tissue: rs1053049, P = 0.01) and hepatic lipids (rs1053049, P = 0.04; rs6902123, P = 0.001; independent of changes in adiposity) as well as LI-induced increase in relative muscle volume of the leg (rs1053049, P = 0.003; rs2267668, P = 0.009) were less pronounced in homo- and heterozygous carriers of the minor alleles as compared with homozygous carriers of the major alleles.CONCLUSION: SNPs rs1053049, rs6902123, and rs2267668 in PPARD affect LI-induced changes in overall adiposity, hepatic fat storage, and relative muscle mass. Our findings provide a mechanistic explanation for the involvement of these genetic variations in the development of insulin resistance and type 2 diabetes.
AB - CONTEXT: We recently demonstrated that single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-delta gene (PPARD), i.e. rs1053049, rs6902123, and rs2267668, affect the improvement of mitochondrial function, aerobic physical fitness, and insulin sensitivity by lifestyle intervention (LI).OBJECTIVE: The objective of the study was to determine whether the aforementioned PPARD SNPs influence the change in body composition and ectopic fat storage during LI.DESIGN: A total of 156 subjects at an increased risk for type 2 diabetes were genotyped for rs1053049, rs6902123, and rs2267668 and participated in a LI program. Body fat depots, ectopic liver fat, and muscle volume of the leg were quantified using magnetic resonance spectroscopy and imaging.RESULTS: With regard to body composition, carriers of the minor SNP alleles displayed reduced responses to LI, i.e. LI-induced reduction in adipose tissue mass (nonvisceral adipose tissue: rs1053049, P = 0.02; rs2267668, P = 0.04; visceral adipose tissue: rs1053049, P = 0.01) and hepatic lipids (rs1053049, P = 0.04; rs6902123, P = 0.001; independent of changes in adiposity) as well as LI-induced increase in relative muscle volume of the leg (rs1053049, P = 0.003; rs2267668, P = 0.009) were less pronounced in homo- and heterozygous carriers of the minor alleles as compared with homozygous carriers of the major alleles.CONCLUSION: SNPs rs1053049, rs6902123, and rs2267668 in PPARD affect LI-induced changes in overall adiposity, hepatic fat storage, and relative muscle mass. Our findings provide a mechanistic explanation for the involvement of these genetic variations in the development of insulin resistance and type 2 diabetes.
KW - Adiposity
KW - Adult
KW - Aged
KW - Body Composition
KW - Diet
KW - Exercise
KW - Female
KW - Humans
KW - Insulin Resistance
KW - Life Style
KW - Magnetic Resonance Imaging
KW - Magnetic Resonance Spectroscopy
KW - Male
KW - Middle Aged
KW - PPAR delta
KW - Polymorphism, Single Nucleotide
U2 - 10.1210/jc.2007-1209
DO - 10.1210/jc.2007-1209
M3 - SCORING: Journal article
C2 - 18252792
VL - 93
SP - 1497
EP - 1500
JO - J CLIN ENDOCR METAB
JF - J CLIN ENDOCR METAB
SN - 0021-972X
IS - 4
ER -