Variability of cortical oscillation patterns: A possible endophenotype in autism spectrum disorders?
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Variability of cortical oscillation patterns: A possible endophenotype in autism spectrum disorders? / David, Nicole; Schneider, Till R; Peiker, Ina; Al-Jawahiri, Reem; Engel, Andreas K; Milne, Elizabeth.
In: NEUROSCI BIOBEHAV R, Vol. 71, 13.10.2016, p. 590-600.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Variability of cortical oscillation patterns: A possible endophenotype in autism spectrum disorders?
AU - David, Nicole
AU - Schneider, Till R
AU - Peiker, Ina
AU - Al-Jawahiri, Reem
AU - Engel, Andreas K
AU - Milne, Elizabeth
N1 - Copyright © 2016. Published by Elsevier Ltd.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Autism spectrum disorders (ASD) have been associated with altered neural oscillations, especially fast oscillatory activity in the gamma frequency range, suggesting fundamentally disturbed temporal coordination of activity during information processing. A detailed review of available cortical oscillation studies in ASD does not convey a clear-cut picture with respect to dysfunctional oscillation patterns in the gamma or other frequency ranges. Recent evidence suggests that instead of a general failure to activate or synchronize the cortex, there is greater intra-participant variability across behavioral, fMRI and EEG responses in ASD. Intra-individual fluctuations from one trial to another have been largely ignored in task-related neural oscillation studies of ASD, which instead have focused on mean changes in power. We highlight new avenues for the analysis of cortical oscillation patterns in ASD which are sensitive to trial-to-trial variability within the participant, in order to validate the significance of increased response variability as possible endophenotype of the disorder.
AB - Autism spectrum disorders (ASD) have been associated with altered neural oscillations, especially fast oscillatory activity in the gamma frequency range, suggesting fundamentally disturbed temporal coordination of activity during information processing. A detailed review of available cortical oscillation studies in ASD does not convey a clear-cut picture with respect to dysfunctional oscillation patterns in the gamma or other frequency ranges. Recent evidence suggests that instead of a general failure to activate or synchronize the cortex, there is greater intra-participant variability across behavioral, fMRI and EEG responses in ASD. Intra-individual fluctuations from one trial to another have been largely ignored in task-related neural oscillation studies of ASD, which instead have focused on mean changes in power. We highlight new avenues for the analysis of cortical oscillation patterns in ASD which are sensitive to trial-to-trial variability within the participant, in order to validate the significance of increased response variability as possible endophenotype of the disorder.
U2 - 10.1016/j.neubiorev.2016.09.031
DO - 10.1016/j.neubiorev.2016.09.031
M3 - SCORING: Journal article
C2 - 27746319
VL - 71
SP - 590
EP - 600
JO - NEUROSCI BIOBEHAV R
JF - NEUROSCI BIOBEHAV R
SN - 0149-7634
ER -