Variability in the human entorhinal region may confound neuropsychiatric diagnoses.
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Variability in the human entorhinal region may confound neuropsychiatric diagnoses. / Heinsen, H; Gössmann, E; Rüb, U; Eisenmenger, W; Bauer, M; Ulmar, G; Bethke, B; Schüler, M; Schmitt, H P; Götz, M; Lockemann, Ute; Püschel, K.
In: Acta Anat (Basel), Vol. 157, No. 3, 3, 1996, p. 226-237.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Variability in the human entorhinal region may confound neuropsychiatric diagnoses.
AU - Heinsen, H
AU - Gössmann, E
AU - Rüb, U
AU - Eisenmenger, W
AU - Bauer, M
AU - Ulmar, G
AU - Bethke, B
AU - Schüler, M
AU - Schmitt, H P
AU - Götz, M
AU - Lockemann, Ute
AU - Püschel, K
PY - 1996
Y1 - 1996
N2 - The human entorhinal region consists of a number of areas; however, there is no generally accepted nomenclature for these cytoarchitectonic fields, and the designation of its constituent layers or strata is a matter of controversy. Here, we consider a hitherto neglected adjacent field, the preamygdaloid claustrocortex. Its medial subfield has a small common border with the rostromedial entorhinal region (width maximal 2 mm). Both fields are cytoarchitectonically rather similar. The rostromedial oral entorhinal field lacks ascending terminal islands. Its unusually small pre-alpha cells are arranged in a thin band or small clusters consisting of pyramidal, triangular, or polymorphic cells. The conspicuous chromophilic pre-beta cell clusters are composed of a variety of cell types, including groups of 'immature' spindle-shaped or bipolar nerve cells. Furthermore, a rare sulcus within the entorhinal region (central sulcus of the entorhinal region: observed in 4% of the 450 brains examined) is associated with an unusual lamination of the entorhinal layers in its wall and floor. Both the specific shape and arrangement of neurones in the claustrocortical-rostral entorhinal border region and the unusual lamination within the rare central entorhinal sulcus are regarded as reflecting neurodevelopmental disturbances characteristic of schizophrenic brains. In contrast, our observations in a large sample of serially sectioned brains from controls, schizophrenics, and patients suffering from neuropsychiatric diseases other than schizophrenia do not support this assumption.
AB - The human entorhinal region consists of a number of areas; however, there is no generally accepted nomenclature for these cytoarchitectonic fields, and the designation of its constituent layers or strata is a matter of controversy. Here, we consider a hitherto neglected adjacent field, the preamygdaloid claustrocortex. Its medial subfield has a small common border with the rostromedial entorhinal region (width maximal 2 mm). Both fields are cytoarchitectonically rather similar. The rostromedial oral entorhinal field lacks ascending terminal islands. Its unusually small pre-alpha cells are arranged in a thin band or small clusters consisting of pyramidal, triangular, or polymorphic cells. The conspicuous chromophilic pre-beta cell clusters are composed of a variety of cell types, including groups of 'immature' spindle-shaped or bipolar nerve cells. Furthermore, a rare sulcus within the entorhinal region (central sulcus of the entorhinal region: observed in 4% of the 450 brains examined) is associated with an unusual lamination of the entorhinal layers in its wall and floor. Both the specific shape and arrangement of neurones in the claustrocortical-rostral entorhinal border region and the unusual lamination within the rare central entorhinal sulcus are regarded as reflecting neurodevelopmental disturbances characteristic of schizophrenic brains. In contrast, our observations in a large sample of serially sectioned brains from controls, schizophrenics, and patients suffering from neuropsychiatric diseases other than schizophrenia do not support this assumption.
M3 - SCORING: Zeitschriftenaufsatz
VL - 157
SP - 226
EP - 237
IS - 3
M1 - 3
ER -