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VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy

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VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy. / Fonseca, Ana Maria; González, Raquel; Bardají, Azucena; Jairoce, Chenjerai; Rupérez, Maria; Jiménez, Alfons; Quintó, Llorenç; Cisteró, Pau; Vala, Anifa; Sacoor, Charfudin; Gupta, Himanshu; Hegewisch-Taylor, Jennifer; Brew, Joe; Ndam, Nicaise Tuikue; Kariuki, Simon; López, Marta; Dobaño, Carlota; Chitnis, Chetan E; Ouma, Peter; Ramharter, Michael; Abdulla, Salim; Aponte, John J; Massougbodji, Achille; Briand, Valerie; Mombo-Ngoma, Ghyslain; Desai, Meghna; Cot, Michel; Nhacolo, Arsenio; Sevene, Esperança; Macete, Eusebio; Menéndez, Clara; Mayor, Alfredo.

In: EMERG INFECT DIS, Vol. 25, No. 10, 10.2019, p. 1851-1860.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fonseca, AM, González, R, Bardají, A, Jairoce, C, Rupérez, M, Jiménez, A, Quintó, L, Cisteró, P, Vala, A, Sacoor, C, Gupta, H, Hegewisch-Taylor, J, Brew, J, Ndam, NT, Kariuki, S, López, M, Dobaño, C, Chitnis, CE, Ouma, P, Ramharter, M, Abdulla, S, Aponte, JJ, Massougbodji, A, Briand, V, Mombo-Ngoma, G, Desai, M, Cot, M, Nhacolo, A, Sevene, E, Macete, E, Menéndez, C & Mayor, A 2019, 'VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy', EMERG INFECT DIS, vol. 25, no. 10, pp. 1851-1860. https://doi.org/10.3201/eid2510.181177

APA

Fonseca, A. M., González, R., Bardají, A., Jairoce, C., Rupérez, M., Jiménez, A., Quintó, L., Cisteró, P., Vala, A., Sacoor, C., Gupta, H., Hegewisch-Taylor, J., Brew, J., Ndam, N. T., Kariuki, S., López, M., Dobaño, C., Chitnis, C. E., Ouma, P., ... Mayor, A. (2019). VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy. EMERG INFECT DIS, 25(10), 1851-1860. https://doi.org/10.3201/eid2510.181177

Vancouver

Fonseca AM, González R, Bardají A, Jairoce C, Rupérez M, Jiménez A et al. VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy. EMERG INFECT DIS. 2019 Oct;25(10):1851-1860. https://doi.org/10.3201/eid2510.181177

Bibtex

@article{c837d0b2bba44bce80581848cd813c0b,
title = "VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy",
abstract = "Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.",
keywords = "Adult, Antibodies, Protozoan/immunology, Antigens, Protozoan/blood, Benin/epidemiology, Female, Gabon/epidemiology, Humans, Immunoglobulin G/immunology, Kenya/epidemiology, Malaria, Falciparum/complications, Mozambique/epidemiology, Plasmodium falciparum/immunology, Pregnancy, Pregnancy Complications, Parasitic/blood, Serologic Tests/methods, Spain/epidemiology, Tanzania/epidemiology, Young Adult",
author = "Fonseca, {Ana Maria} and Raquel Gonz{\'a}lez and Azucena Bardaj{\'i} and Chenjerai Jairoce and Maria Rup{\'e}rez and Alfons Jim{\'e}nez and Lloren{\c c} Quint{\'o} and Pau Cister{\'o} and Anifa Vala and Charfudin Sacoor and Himanshu Gupta and Jennifer Hegewisch-Taylor and Joe Brew and Ndam, {Nicaise Tuikue} and Simon Kariuki and Marta L{\'o}pez and Carlota Doba{\~n}o and Chitnis, {Chetan E} and Peter Ouma and Michael Ramharter and Salim Abdulla and Aponte, {John J} and Achille Massougbodji and Valerie Briand and Ghyslain Mombo-Ngoma and Meghna Desai and Michel Cot and Arsenio Nhacolo and Esperan{\c c}a Sevene and Eusebio Macete and Clara Men{\'e}ndez and Alfredo Mayor",
year = "2019",
month = oct,
doi = "10.3201/eid2510.181177",
language = "English",
volume = "25",
pages = "1851--1860",
journal = "EMERG INFECT DIS",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "10",

}

RIS

TY - JOUR

T1 - VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy

AU - Fonseca, Ana Maria

AU - González, Raquel

AU - Bardají, Azucena

AU - Jairoce, Chenjerai

AU - Rupérez, Maria

AU - Jiménez, Alfons

AU - Quintó, Llorenç

AU - Cisteró, Pau

AU - Vala, Anifa

AU - Sacoor, Charfudin

AU - Gupta, Himanshu

AU - Hegewisch-Taylor, Jennifer

AU - Brew, Joe

AU - Ndam, Nicaise Tuikue

AU - Kariuki, Simon

AU - López, Marta

AU - Dobaño, Carlota

AU - Chitnis, Chetan E

AU - Ouma, Peter

AU - Ramharter, Michael

AU - Abdulla, Salim

AU - Aponte, John J

AU - Massougbodji, Achille

AU - Briand, Valerie

AU - Mombo-Ngoma, Ghyslain

AU - Desai, Meghna

AU - Cot, Michel

AU - Nhacolo, Arsenio

AU - Sevene, Esperança

AU - Macete, Eusebio

AU - Menéndez, Clara

AU - Mayor, Alfredo

PY - 2019/10

Y1 - 2019/10

N2 - Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

AB - Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

KW - Adult

KW - Antibodies, Protozoan/immunology

KW - Antigens, Protozoan/blood

KW - Benin/epidemiology

KW - Female

KW - Gabon/epidemiology

KW - Humans

KW - Immunoglobulin G/immunology

KW - Kenya/epidemiology

KW - Malaria, Falciparum/complications

KW - Mozambique/epidemiology

KW - Plasmodium falciparum/immunology

KW - Pregnancy

KW - Pregnancy Complications, Parasitic/blood

KW - Serologic Tests/methods

KW - Spain/epidemiology

KW - Tanzania/epidemiology

KW - Young Adult

U2 - 10.3201/eid2510.181177

DO - 10.3201/eid2510.181177

M3 - SCORING: Journal article

C2 - 31538557

VL - 25

SP - 1851

EP - 1860

JO - EMERG INFECT DIS

JF - EMERG INFECT DIS

SN - 1080-6040

IS - 10

ER -