Validation of six closely linked STRs located in the chromosome X centromere region.
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Validation of six closely linked STRs located in the chromosome X centromere region. / Edelmann, Jeanett; Hering, Sandra; Augustin, Christa; Kalis, Stefan; Szibor, Reinhard.
In: INT J LEGAL MED, Vol. 124, No. 1, 1, 2010, p. 83-87.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Validation of six closely linked STRs located in the chromosome X centromere region.
AU - Edelmann, Jeanett
AU - Hering, Sandra
AU - Augustin, Christa
AU - Kalis, Stefan
AU - Szibor, Reinhard
PY - 2010
Y1 - 2010
N2 - We propose that clusters of closely linked markers, which segregate as stable haplotypes, provide a high potential to solve complex kinship cases. It is known that the X-chromosomal centromere region shows an extremely low degree of recombination. Hence, we focused our interest on the region between 56 and 64 Mb distant from the Xp telomere and considered 6 STRs which are now registered in the Genome Data Base as DXS10161, DXS10159, DXS10162, DXS10163, DXS10164, and DXS10165. All of these markers show a tetranucleotide or pentanucleotide structure and exhibit high or medium polymorphic information content. As a peculiarity, DXS10163 is a combination of a pentanucleotide STR and an 18 bp INDEL polymorphism. We report here the primer sequences, the repeat structures, the allele distributions and parameters of forensic interest for a German population sample.
AB - We propose that clusters of closely linked markers, which segregate as stable haplotypes, provide a high potential to solve complex kinship cases. It is known that the X-chromosomal centromere region shows an extremely low degree of recombination. Hence, we focused our interest on the region between 56 and 64 Mb distant from the Xp telomere and considered 6 STRs which are now registered in the Genome Data Base as DXS10161, DXS10159, DXS10162, DXS10163, DXS10164, and DXS10165. All of these markers show a tetranucleotide or pentanucleotide structure and exhibit high or medium polymorphic information content. As a peculiarity, DXS10163 is a combination of a pentanucleotide STR and an 18 bp INDEL polymorphism. We report here the primer sequences, the repeat structures, the allele distributions and parameters of forensic interest for a German population sample.
M3 - SCORING: Zeitschriftenaufsatz
VL - 124
SP - 83
EP - 87
JO - INT J LEGAL MED
JF - INT J LEGAL MED
SN - 0937-9827
IS - 1
M1 - 1
ER -
