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Utility of N-terminal brain natriuretic peptide plasma concentrations in comparison to lactate and troponin in children with congenital heart disease following open-heart surgery

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Utility of N-terminal brain natriuretic peptide plasma concentrations in comparison to lactate and troponin in children with congenital heart disease following open-heart surgery. / Mir, T S; Haun, C; Lilje, C; Läer, S; Weil, J.

In: PEDIATR CARDIOL, Vol. 27, No. 2, 05.01.2006, p. 209-216.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mir, TS, Haun, C, Lilje, C, Läer, S & Weil, J 2006, 'Utility of N-terminal brain natriuretic peptide plasma concentrations in comparison to lactate and troponin in children with congenital heart disease following open-heart surgery', PEDIATR CARDIOL, vol. 27, no. 2, pp. 209-216. https://doi.org/10.1007/s00246-005-1152-8

APA

Mir, T. S., Haun, C., Lilje, C., Läer, S., & Weil, J. (2006). Utility of N-terminal brain natriuretic peptide plasma concentrations in comparison to lactate and troponin in children with congenital heart disease following open-heart surgery. PEDIATR CARDIOL, 27(2), 209-216. https://doi.org/10.1007/s00246-005-1152-8

Vancouver

Mir TS, Haun C, Lilje C, Läer S, Weil J. Utility of N-terminal brain natriuretic peptide plasma concentrations in comparison to lactate and troponin in children with congenital heart disease following open-heart surgery. PEDIATR CARDIOL. 2006 Jan 5;27(2):209-216. https://doi.org/10.1007/s00246-005-1152-8

Bibtex

@article{56f9b653312642a686473e48d40e0a6d,
title = "Utility of N-terminal brain natriuretic peptide plasma concentrations in comparison to lactate and troponin in children with congenital heart disease following open-heart surgery",
abstract = "We conducted a prospective study in a pediatric cardiac intensive care unit in order to determine the diagnostic value of N-terminal brain natriuretic peptide (N-BNP) plasma concentration in the perioperative care of children with congenital heart disease (CHD). N-BNP plasma concentrations were determined by using a validated enzyme immunoassay. We measured N-BNP the day before surgery and up to 15 days postoperatively in 23 children (age range, 0.25-11 years) undergoing cardiac surgery due to various CHDs. Supply and duration of catecholamines, vasodilators, and respiratory therapy were determined and correlated to N-BNP. In addition, troponin T (TnT) and arterial Lactat (aL) concentrations were measured simultaneously. We found a significant correlation between preoperative and maximal N-BNP levels and dosage of vasodilators (r = 0.41, p < 0.02 and r = 0.83, p < 0.01, respectively). Maximal TnT and aL levels were not correlated to dosage of vasodilators. The dosage and duration of catecholamines, the duration of respiratory therapy, and the plasma concentration of TnT and aL were not correlated to pre- or perioperative N-BNP. Maximal TnT and aL levels were correlated to duration (r = 0.53, p < 0.01 and r = 0.48, p < 0.02) and dosage (r = 0.52, p < 0.02 and r = 0.60, p < 0.01) of catecholamines and duration of respiratory therapy (r = 0.57, p < 0.01 and r = 0.50, p < 0.02). As recent studies show, N-BNP appears to be a powerful neurohumoral indicator of ventricular function and prognosis for guiding therapy in the outpatient department or for discriminating cardiac from noncardiac symptoms. In contrast, the value of N-BNP for guiding perioperative therapy in pediatric cardiac intensive care units is limited.",
keywords = "Child, Child, Preschool, Female, Heart Defects, Congenital/complications, Heart Failure/diagnosis, Humans, Infant, Lactic Acid/blood, Male, Natriuretic Peptide, Brain/blood, Perioperative Care, Predictive Value of Tests, Prospective Studies, Troponin/blood",
author = "Mir, {T S} and C Haun and C Lilje and S L{\"a}er and J Weil",
year = "2006",
month = jan,
day = "5",
doi = "10.1007/s00246-005-1152-8",
language = "English",
volume = "27",
pages = "209--216",
journal = "PEDIATR CARDIOL",
issn = "0172-0643",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Utility of N-terminal brain natriuretic peptide plasma concentrations in comparison to lactate and troponin in children with congenital heart disease following open-heart surgery

AU - Mir, T S

AU - Haun, C

AU - Lilje, C

AU - Läer, S

AU - Weil, J

PY - 2006/1/5

Y1 - 2006/1/5

N2 - We conducted a prospective study in a pediatric cardiac intensive care unit in order to determine the diagnostic value of N-terminal brain natriuretic peptide (N-BNP) plasma concentration in the perioperative care of children with congenital heart disease (CHD). N-BNP plasma concentrations were determined by using a validated enzyme immunoassay. We measured N-BNP the day before surgery and up to 15 days postoperatively in 23 children (age range, 0.25-11 years) undergoing cardiac surgery due to various CHDs. Supply and duration of catecholamines, vasodilators, and respiratory therapy were determined and correlated to N-BNP. In addition, troponin T (TnT) and arterial Lactat (aL) concentrations were measured simultaneously. We found a significant correlation between preoperative and maximal N-BNP levels and dosage of vasodilators (r = 0.41, p < 0.02 and r = 0.83, p < 0.01, respectively). Maximal TnT and aL levels were not correlated to dosage of vasodilators. The dosage and duration of catecholamines, the duration of respiratory therapy, and the plasma concentration of TnT and aL were not correlated to pre- or perioperative N-BNP. Maximal TnT and aL levels were correlated to duration (r = 0.53, p < 0.01 and r = 0.48, p < 0.02) and dosage (r = 0.52, p < 0.02 and r = 0.60, p < 0.01) of catecholamines and duration of respiratory therapy (r = 0.57, p < 0.01 and r = 0.50, p < 0.02). As recent studies show, N-BNP appears to be a powerful neurohumoral indicator of ventricular function and prognosis for guiding therapy in the outpatient department or for discriminating cardiac from noncardiac symptoms. In contrast, the value of N-BNP for guiding perioperative therapy in pediatric cardiac intensive care units is limited.

AB - We conducted a prospective study in a pediatric cardiac intensive care unit in order to determine the diagnostic value of N-terminal brain natriuretic peptide (N-BNP) plasma concentration in the perioperative care of children with congenital heart disease (CHD). N-BNP plasma concentrations were determined by using a validated enzyme immunoassay. We measured N-BNP the day before surgery and up to 15 days postoperatively in 23 children (age range, 0.25-11 years) undergoing cardiac surgery due to various CHDs. Supply and duration of catecholamines, vasodilators, and respiratory therapy were determined and correlated to N-BNP. In addition, troponin T (TnT) and arterial Lactat (aL) concentrations were measured simultaneously. We found a significant correlation between preoperative and maximal N-BNP levels and dosage of vasodilators (r = 0.41, p < 0.02 and r = 0.83, p < 0.01, respectively). Maximal TnT and aL levels were not correlated to dosage of vasodilators. The dosage and duration of catecholamines, the duration of respiratory therapy, and the plasma concentration of TnT and aL were not correlated to pre- or perioperative N-BNP. Maximal TnT and aL levels were correlated to duration (r = 0.53, p < 0.01 and r = 0.48, p < 0.02) and dosage (r = 0.52, p < 0.02 and r = 0.60, p < 0.01) of catecholamines and duration of respiratory therapy (r = 0.57, p < 0.01 and r = 0.50, p < 0.02). As recent studies show, N-BNP appears to be a powerful neurohumoral indicator of ventricular function and prognosis for guiding therapy in the outpatient department or for discriminating cardiac from noncardiac symptoms. In contrast, the value of N-BNP for guiding perioperative therapy in pediatric cardiac intensive care units is limited.

KW - Child

KW - Child, Preschool

KW - Female

KW - Heart Defects, Congenital/complications

KW - Heart Failure/diagnosis

KW - Humans

KW - Infant

KW - Lactic Acid/blood

KW - Male

KW - Natriuretic Peptide, Brain/blood

KW - Perioperative Care

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Troponin/blood

U2 - 10.1007/s00246-005-1152-8

DO - 10.1007/s00246-005-1152-8

M3 - SCORING: Journal article

C2 - 16391984

VL - 27

SP - 209

EP - 216

JO - PEDIATR CARDIOL

JF - PEDIATR CARDIOL

SN - 0172-0643

IS - 2

ER -