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Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction

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Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction. / von Jeinsen, Beatrice; Kraus, Daniel; Palapies, Lars; Tzikas, Stergios; Zeller, Tanja; Schauer, Anne; Drechsler, Christiane; Bickel, Christoph; Baldus, Stephan; Lackner, Karl J; Münzel, Thomas; Blankenberg, Stefan; Zeiher, Andreas M; Keller, Till.

In: INT J CARDIOL, Vol. 245, 15.10.2017, p. 6-12.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

von Jeinsen, B, Kraus, D, Palapies, L, Tzikas, S, Zeller, T, Schauer, A, Drechsler, C, Bickel, C, Baldus, S, Lackner, KJ, Münzel, T, Blankenberg, S, Zeiher, AM & Keller, T 2017, 'Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction', INT J CARDIOL, vol. 245, pp. 6-12. https://doi.org/10.1016/j.ijcard.2017.07.086

APA

von Jeinsen, B., Kraus, D., Palapies, L., Tzikas, S., Zeller, T., Schauer, A., Drechsler, C., Bickel, C., Baldus, S., Lackner, K. J., Münzel, T., Blankenberg, S., Zeiher, A. M., & Keller, T. (2017). Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction. INT J CARDIOL, 245, 6-12. https://doi.org/10.1016/j.ijcard.2017.07.086

Vancouver

von Jeinsen B, Kraus D, Palapies L, Tzikas S, Zeller T, Schauer A et al. Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction. INT J CARDIOL. 2017 Oct 15;245:6-12. https://doi.org/10.1016/j.ijcard.2017.07.086

Bibtex

@article{3c4bf19fb7314f0587bbc38e95db31ec,
title = "Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction",
abstract = "INTRODUCTION: Impaired renal function, reflected by estimated glomerular filtration rate (eGFR) or cystatin C, is a strong risk predictor in the presence of acute myocardial infarction (AMI). Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is an early marker of acute kidney injury. uNGAL might also be a good predictor of outcome in patients with cardiovascular disease. Aim of the present study was to evaluate the prognostic value of uNGAL compared to eGFR and cystatin C in patients with suspected AMI.METHODS: 1818 patients were enrolled with suspected AMI. Follow-up information on the combined endpoint of death or non-fatal myocardial infarction was obtained 6months after enrolment and was available in 1804 patients. 63 events (3.5%) were registered.RESULTS: While cystatin C and eGFR were strong risk predictors for the primary endpoint even adjusted for several variables, uNGAL was not independently associated with outcome: When applied continuously uNGAL was associated with outcome but did not remain a statistically significant predictor after several adjustments (i.e. eGFR). By adding cystatin C or uNGAL to GRACE risk score variables, only cystatin C could improve the predictive value while uNGAL showed no improvement.CONCLUSION: We could show that cystatin C is an independent risk predictor in patients with suspected AMI and cystatin C can add improvement to the commonly used GRACE risk score. In contrast uNGAL is not independently associated with outcome and seems not to add further prognostic information to GRACE risk score.",
keywords = "Aged, Aged, 80 and over, Biomarkers/urine, Cohort Studies, Cystatin C/urine, Female, Follow-Up Studies, Glomerular Filtration Rate/physiology, Humans, Lipocalin-2/urine, Male, Middle Aged, Myocardial Infarction/diagnosis, Predictive Value of Tests, Risk Factors",
author = "{von Jeinsen}, Beatrice and Daniel Kraus and Lars Palapies and Stergios Tzikas and Tanja Zeller and Anne Schauer and Christiane Drechsler and Christoph Bickel and Stephan Baldus and Lackner, {Karl J} and Thomas M{\"u}nzel and Stefan Blankenberg and Zeiher, {Andreas M} and Till Keller",
note = "Copyright {\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = oct,
day = "15",
doi = "10.1016/j.ijcard.2017.07.086",
language = "English",
volume = "245",
pages = "6--12",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction

AU - von Jeinsen, Beatrice

AU - Kraus, Daniel

AU - Palapies, Lars

AU - Tzikas, Stergios

AU - Zeller, Tanja

AU - Schauer, Anne

AU - Drechsler, Christiane

AU - Bickel, Christoph

AU - Baldus, Stephan

AU - Lackner, Karl J

AU - Münzel, Thomas

AU - Blankenberg, Stefan

AU - Zeiher, Andreas M

AU - Keller, Till

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/10/15

Y1 - 2017/10/15

N2 - INTRODUCTION: Impaired renal function, reflected by estimated glomerular filtration rate (eGFR) or cystatin C, is a strong risk predictor in the presence of acute myocardial infarction (AMI). Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is an early marker of acute kidney injury. uNGAL might also be a good predictor of outcome in patients with cardiovascular disease. Aim of the present study was to evaluate the prognostic value of uNGAL compared to eGFR and cystatin C in patients with suspected AMI.METHODS: 1818 patients were enrolled with suspected AMI. Follow-up information on the combined endpoint of death or non-fatal myocardial infarction was obtained 6months after enrolment and was available in 1804 patients. 63 events (3.5%) were registered.RESULTS: While cystatin C and eGFR were strong risk predictors for the primary endpoint even adjusted for several variables, uNGAL was not independently associated with outcome: When applied continuously uNGAL was associated with outcome but did not remain a statistically significant predictor after several adjustments (i.e. eGFR). By adding cystatin C or uNGAL to GRACE risk score variables, only cystatin C could improve the predictive value while uNGAL showed no improvement.CONCLUSION: We could show that cystatin C is an independent risk predictor in patients with suspected AMI and cystatin C can add improvement to the commonly used GRACE risk score. In contrast uNGAL is not independently associated with outcome and seems not to add further prognostic information to GRACE risk score.

AB - INTRODUCTION: Impaired renal function, reflected by estimated glomerular filtration rate (eGFR) or cystatin C, is a strong risk predictor in the presence of acute myocardial infarction (AMI). Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is an early marker of acute kidney injury. uNGAL might also be a good predictor of outcome in patients with cardiovascular disease. Aim of the present study was to evaluate the prognostic value of uNGAL compared to eGFR and cystatin C in patients with suspected AMI.METHODS: 1818 patients were enrolled with suspected AMI. Follow-up information on the combined endpoint of death or non-fatal myocardial infarction was obtained 6months after enrolment and was available in 1804 patients. 63 events (3.5%) were registered.RESULTS: While cystatin C and eGFR were strong risk predictors for the primary endpoint even adjusted for several variables, uNGAL was not independently associated with outcome: When applied continuously uNGAL was associated with outcome but did not remain a statistically significant predictor after several adjustments (i.e. eGFR). By adding cystatin C or uNGAL to GRACE risk score variables, only cystatin C could improve the predictive value while uNGAL showed no improvement.CONCLUSION: We could show that cystatin C is an independent risk predictor in patients with suspected AMI and cystatin C can add improvement to the commonly used GRACE risk score. In contrast uNGAL is not independently associated with outcome and seems not to add further prognostic information to GRACE risk score.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/urine

KW - Cohort Studies

KW - Cystatin C/urine

KW - Female

KW - Follow-Up Studies

KW - Glomerular Filtration Rate/physiology

KW - Humans

KW - Lipocalin-2/urine

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/diagnosis

KW - Predictive Value of Tests

KW - Risk Factors

U2 - 10.1016/j.ijcard.2017.07.086

DO - 10.1016/j.ijcard.2017.07.086

M3 - SCORING: Journal article

C2 - 28778467

VL - 245

SP - 6

EP - 12

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -