Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease

Fabian Braun; Roman-Ulrich Müller

doi:10.1016/bs.mcb.2019.04.014

Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease

Standard

Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease. / Braun, Fabian; Müller, Roman-Ulrich.

In: METHODS CELL BIOL, Vol. 154, 2019, p. 43-65.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Braun, F & Müller, R-U 2019, 'Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease', METHODS CELL BIOL, vol. 154, pp. 43-65. https://doi.org/10.1016/bs.mcb.2019.04.014

APA

Braun, F., & Müller, R-U. (2019). Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease. METHODS CELL BIOL, 154, 43-65. https://doi.org/10.1016/bs.mcb.2019.04.014

Vancouver

Braun F, Müller R-U. Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease. METHODS CELL BIOL. 2019;154:43-65. https://doi.org/10.1016/bs.mcb.2019.04.014

Bibtex

@article{e09d23bef01c4d33838548b7ab5e38e4,

title = "Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease",

abstract = "For more than a decade, extracellular vesicles (EVs) have been the focus of extensive research efforts attempting to uncover their biological function in health and disease. Likewise, numerous studies have investigated them as a source of potential biomarkers to complement or replace the routine diagnostic procedures. Urinary extracellular vesicles take a distinct place among these studies, as they hold the promise to reflect changes in the cellular biology of the nephron and can be isolated without any invasive procedure. However, their potential has been insufficiently exploited since both their biological function and their use for diagnostic purposes in human disease have only gained increasing attention in the last years. This review aims to give an overview of the present knowledge about urinary extracellular vesicles with a special focus on novel nomenclature recommendations, current techniques for urinary EV separation and potential biomarkers that have emerged from the analysis of urinary EVs.",

keywords = "Biomarkers/analysis, Extracellular Vesicles/chemistry, Filtration/methods, Fractional Precipitation/methods, Humans, Kidney Diseases/diagnosis, Kidney/metabolism, Ultracentrifugation/methods, Urinalysis/methods",

author = "Fabian Braun and Roman-Ulrich M{\"u}ller",

year = "2019",

doi = "10.1016/bs.mcb.2019.04.014",

language = "English",

volume = "154",

pages = "43--65",

journal = "METHODS CELL BIOL",

issn = "0091-679X",

publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Urinary extracellular vesicles as a source of biomarkers reflecting renal cellular biology in human disease

AU - Braun, Fabian

AU - Müller, Roman-Ulrich

PY - 2019

Y1 - 2019

N2 - For more than a decade, extracellular vesicles (EVs) have been the focus of extensive research efforts attempting to uncover their biological function in health and disease. Likewise, numerous studies have investigated them as a source of potential biomarkers to complement or replace the routine diagnostic procedures. Urinary extracellular vesicles take a distinct place among these studies, as they hold the promise to reflect changes in the cellular biology of the nephron and can be isolated without any invasive procedure. However, their potential has been insufficiently exploited since both their biological function and their use for diagnostic purposes in human disease have only gained increasing attention in the last years. This review aims to give an overview of the present knowledge about urinary extracellular vesicles with a special focus on novel nomenclature recommendations, current techniques for urinary EV separation and potential biomarkers that have emerged from the analysis of urinary EVs.

AB - For more than a decade, extracellular vesicles (EVs) have been the focus of extensive research efforts attempting to uncover their biological function in health and disease. Likewise, numerous studies have investigated them as a source of potential biomarkers to complement or replace the routine diagnostic procedures. Urinary extracellular vesicles take a distinct place among these studies, as they hold the promise to reflect changes in the cellular biology of the nephron and can be isolated without any invasive procedure. However, their potential has been insufficiently exploited since both their biological function and their use for diagnostic purposes in human disease have only gained increasing attention in the last years. This review aims to give an overview of the present knowledge about urinary extracellular vesicles with a special focus on novel nomenclature recommendations, current techniques for urinary EV separation and potential biomarkers that have emerged from the analysis of urinary EVs.

KW - Biomarkers/analysis

KW - Extracellular Vesicles/chemistry

KW - Filtration/methods

KW - Fractional Precipitation/methods

KW - Humans

KW - Kidney Diseases/diagnosis

KW - Kidney/metabolism

KW - Ultracentrifugation/methods

KW - Urinalysis/methods

U2 - 10.1016/bs.mcb.2019.04.014

DO - 10.1016/bs.mcb.2019.04.014

M3 - SCORING: Review article

C2 - 31493821

VL - 154

SP - 43

EP - 65

JO - METHODS CELL BIOL

JF - METHODS CELL BIOL

SN - 0091-679X

ER -