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Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.

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Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1. / García-Palma, Lizet; Horn, Stefan; Haag, Friedrich; Diessenbacher, Philip; Streichert, Thomas; Mayr, Georg W.; Jücker, Manfred.

In: BRIT J HAEMATOL, Vol. 131, No. 5, 5, 2005, p. 628-631.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

García-Palma, L, Horn, S, Haag, F, Diessenbacher, P, Streichert, T, Mayr, GW & Jücker, M 2005, 'Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.', BRIT J HAEMATOL, vol. 131, no. 5, 5, pp. 628-631. <http://www.ncbi.nlm.nih.gov/pubmed/16351639?dopt=Citation>

APA

García-Palma, L., Horn, S., Haag, F., Diessenbacher, P., Streichert, T., Mayr, G. W., & Jücker, M. (2005). Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1. BRIT J HAEMATOL, 131(5), 628-631. [5]. http://www.ncbi.nlm.nih.gov/pubmed/16351639?dopt=Citation

Vancouver

García-Palma L, Horn S, Haag F, Diessenbacher P, Streichert T, Mayr GW et al. Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1. BRIT J HAEMATOL. 2005;131(5):628-631. 5.

Bibtex

@article{e89bdb7543c241ca9e45741e04e293d3,
title = "Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.",
abstract = "Inositol 5'-phosphatase SHIP-1 (SHIP) is a negative regulator of signal transduction in haematopoietic cells. SHIP inactivation may be involved in the pathogenesis of leukaemia. An inducible expression system was combined with microarray analysis to identify target genes regulated by SHIP in the human T-cell leukaemia cell line Jurkat. One gene identified was Kr{\"u}ppel-like factor 2 (KLF2), which was up-regulated two to threefold at the RNA and protein level after the induced expression of SHIP. KLF2, a negative regulator of T cell proliferation, has been implicated in T cell quiescence. KLF2 or SHIP expression in Jurkat cells caused 45% or 60% reduction of proliferation, respectively. SHIP can up-regulate KLF2 expression, implicating KLF2 in the SHIP-mediated growth inhibition of a human leukaemic T-cell line.",
author = "Lizet Garc{\'i}a-Palma and Stefan Horn and Friedrich Haag and Philip Diessenbacher and Thomas Streichert and Mayr, {Georg W.} and Manfred J{\"u}cker",
year = "2005",
language = "Deutsch",
volume = "131",
pages = "628--631",
journal = "BRIT J HAEMATOL",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.

AU - García-Palma, Lizet

AU - Horn, Stefan

AU - Haag, Friedrich

AU - Diessenbacher, Philip

AU - Streichert, Thomas

AU - Mayr, Georg W.

AU - Jücker, Manfred

PY - 2005

Y1 - 2005

N2 - Inositol 5'-phosphatase SHIP-1 (SHIP) is a negative regulator of signal transduction in haematopoietic cells. SHIP inactivation may be involved in the pathogenesis of leukaemia. An inducible expression system was combined with microarray analysis to identify target genes regulated by SHIP in the human T-cell leukaemia cell line Jurkat. One gene identified was Krüppel-like factor 2 (KLF2), which was up-regulated two to threefold at the RNA and protein level after the induced expression of SHIP. KLF2, a negative regulator of T cell proliferation, has been implicated in T cell quiescence. KLF2 or SHIP expression in Jurkat cells caused 45% or 60% reduction of proliferation, respectively. SHIP can up-regulate KLF2 expression, implicating KLF2 in the SHIP-mediated growth inhibition of a human leukaemic T-cell line.

AB - Inositol 5'-phosphatase SHIP-1 (SHIP) is a negative regulator of signal transduction in haematopoietic cells. SHIP inactivation may be involved in the pathogenesis of leukaemia. An inducible expression system was combined with microarray analysis to identify target genes regulated by SHIP in the human T-cell leukaemia cell line Jurkat. One gene identified was Krüppel-like factor 2 (KLF2), which was up-regulated two to threefold at the RNA and protein level after the induced expression of SHIP. KLF2, a negative regulator of T cell proliferation, has been implicated in T cell quiescence. KLF2 or SHIP expression in Jurkat cells caused 45% or 60% reduction of proliferation, respectively. SHIP can up-regulate KLF2 expression, implicating KLF2 in the SHIP-mediated growth inhibition of a human leukaemic T-cell line.

M3 - SCORING: Zeitschriftenaufsatz

VL - 131

SP - 628

EP - 631

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 5

M1 - 5

ER -