Untersuchungen zur beta-Dosimetrie an zwei unterschiedlichen Quellen für die kardiovaskuläre Brachytherapie
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Untersuchungen zur beta-Dosimetrie an zwei unterschiedlichen Quellen für die kardiovaskuläre Brachytherapie. / Todorovic, Manuel; Cremers, Florian; Thurmann, Horst; Schmidt, Rainer.
In: Z MED PHYS, Vol. 15, No. 1, 2005, p. 23-30.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Untersuchungen zur beta-Dosimetrie an zwei unterschiedlichen Quellen für die kardiovaskuläre Brachytherapie
AU - Todorovic, Manuel
AU - Cremers, Florian
AU - Thurmann, Horst
AU - Schmidt, Rainer
PY - 2005
Y1 - 2005
N2 - The intracoronary brachytherapy is used at the Hamburg University Hospital as a method to treat in-stent restenosis. Two different radiochromic film types were applied to obtain dosimetric information of the beta-sources used (32P and 90Sr/90Y). First, these films were analyzed for their suitability for dosimetry. Within the investigated dose range (MD-55-2: 0 to 33 Gy, HD-810: 0 to 105 Gy), both films showed a linear behavior between the dose and the optical density (OD). Because radiochromic films are subject to time-based changes in OD, a method for colour stabilization was investigated (RCS-method). This method allowed to greatly shorten the time between irradiation and evaluation from 24 hours (time necessary for the film to reach a quasi-stable status) to 2.5 hours. Colour-stabilized films can also be stored for a long time and reanalyzed with almost the same results. Within the limits of the measurements error, both film types showed an energy independent response. Within the dose profiles, analyses of the two source types resulted in differences of 13.5% (32P) and 21% (90Sr/90Y). These inhomogenities are consistent with the fabrication tolerances given by the manufactures.
AB - The intracoronary brachytherapy is used at the Hamburg University Hospital as a method to treat in-stent restenosis. Two different radiochromic film types were applied to obtain dosimetric information of the beta-sources used (32P and 90Sr/90Y). First, these films were analyzed for their suitability for dosimetry. Within the investigated dose range (MD-55-2: 0 to 33 Gy, HD-810: 0 to 105 Gy), both films showed a linear behavior between the dose and the optical density (OD). Because radiochromic films are subject to time-based changes in OD, a method for colour stabilization was investigated (RCS-method). This method allowed to greatly shorten the time between irradiation and evaluation from 24 hours (time necessary for the film to reach a quasi-stable status) to 2.5 hours. Colour-stabilized films can also be stored for a long time and reanalyzed with almost the same results. Within the limits of the measurements error, both film types showed an energy independent response. Within the dose profiles, analyses of the two source types resulted in differences of 13.5% (32P) and 21% (90Sr/90Y). These inhomogenities are consistent with the fabrication tolerances given by the manufactures.
KW - Beta Particles/therapeutic use
KW - Brachytherapy/methods
KW - Coronary Artery Disease/surgery
KW - Coronary Restenosis/radiotherapy
KW - Humans
KW - Radiotherapy Dosage
KW - Stents
U2 - 10.1078/0939-3889-00239
DO - 10.1078/0939-3889-00239
M3 - SCORING: Zeitschriftenaufsatz
C2 - 15830781
VL - 15
SP - 23
EP - 30
JO - Z MED PHYS
JF - Z MED PHYS
SN - 0939-3889
IS - 1
ER -
