Unphysiologically high magnesium concentrations support chondrocyte proliferation and redifferentiation.
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Unphysiologically high magnesium concentrations support chondrocyte proliferation and redifferentiation. / Feyerabend, Frank; Witte, Frank; Kammal, Michael; Willumeit, Regine.
In: TISSUE ENG, Vol. 12, No. 12, 12, 2006, p. 3545-3556.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Unphysiologically high magnesium concentrations support chondrocyte proliferation and redifferentiation.
AU - Feyerabend, Frank
AU - Witte, Frank
AU - Kammal, Michael
AU - Willumeit, Regine
PY - 2006
Y1 - 2006
N2 - The effect of unphysiologically high extracellular magnesium concentrations on chondrocytes, induced by the supplementation of magnesium sulfate, was studied using a 3-phase tissue engineering model. The experiments showed that chondrocyte proliferation and redifferentiation, on the gene and protein expression level, are enhanced. A negative influence was found during chondrogenesis where an inhibition of extracellular matrix formation was observed. In addition, a direct impact on chondrocyte metabolism, elevated magnesium concentrations also affected growth factor effectiveness by consecutive influences during chondrogenesis. All observations were dosage dependent. The results of this study indicate that magnesium may be a useful tool for cartilage tissue engineering.
AB - The effect of unphysiologically high extracellular magnesium concentrations on chondrocytes, induced by the supplementation of magnesium sulfate, was studied using a 3-phase tissue engineering model. The experiments showed that chondrocyte proliferation and redifferentiation, on the gene and protein expression level, are enhanced. A negative influence was found during chondrogenesis where an inhibition of extracellular matrix formation was observed. In addition, a direct impact on chondrocyte metabolism, elevated magnesium concentrations also affected growth factor effectiveness by consecutive influences during chondrogenesis. All observations were dosage dependent. The results of this study indicate that magnesium may be a useful tool for cartilage tissue engineering.
M3 - SCORING: Zeitschriftenaufsatz
VL - 12
SP - 3545
EP - 3556
JO - TISSUE ENG
JF - TISSUE ENG
SN - 1076-3279
IS - 12
M1 - 12
ER -
