Unizentrische, retrospektive Analyse der praktischen Durchführung der extrakorporalen Photopherese
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Unizentrische, retrospektive Analyse der praktischen Durchführung der extrakorporalen Photopherese : Periphervenöser und zentralvenöser Zugang im Vergleich. / Hambsch, Jasmin; Büttner, Sylvia; Heck, Markus; Nicolay, Jan P; Felcht, Moritz; Booken, Nina; Klemke, Claus-Detlev.
In: HAUTARZT, Vol. 70, No. 3, 03.2019, p. 193-203.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Unizentrische, retrospektive Analyse der praktischen Durchführung der extrakorporalen Photopherese
T2 - Periphervenöser und zentralvenöser Zugang im Vergleich
AU - Hambsch, Jasmin
AU - Büttner, Sylvia
AU - Heck, Markus
AU - Nicolay, Jan P
AU - Felcht, Moritz
AU - Booken, Nina
AU - Klemke, Claus-Detlev
PY - 2019/3
Y1 - 2019/3
N2 - BACKGROUND: Extracorporal photopheresis (ECP) was shown to be effective without severe side effects in the treatment of cutaneous T cell lymphoma (CTCL) and graft versus host disease (GvHD). However, only few studies investigated the practical aspects of ECP.METHODS: Treatment protocols of 2038 ECP procedures in 52 patients (CTCL, n = 29; GvHD, n = 15; other, n = 8) were evaluated. The patients were treated with the UVAR® XTS™ ECP system (Therakos, Inc. Johnson & Johnson, Raritan, NJ, USA) between 2001 and 2010. All patients started with a peripheral venous access. During the course of treatment 7 patients were treated via a port and 4 via a central venous catheter.RESULTS: In all, 1765 (86.6%) treatments were performed with a peripheral venous access; 239 (11.7%) ECPs were done via a port and 34 (1.7%) via a central venous catheter. The peripheral venous access showed a higher flow rate and longer photoactivation time. ECPs via port lead to higher UV-irradiated volumes, longer treatment times and higher differences in systolic blood pressure. The following side effects were observed: being unwell (n = 13), hypo- (n = 13) and hypertension (n = 7), vertigo (n = 4), headache (n = 4), shortness of breath (n = 4), fever (n = 3) and metallic taste (n = 3). Technical complications such as problems with venous access (9.6%) occurred in 385 (18.9%) treatments.CONCLUSIONS: Peripheral venous access should be preferred for ECP treatments.
AB - BACKGROUND: Extracorporal photopheresis (ECP) was shown to be effective without severe side effects in the treatment of cutaneous T cell lymphoma (CTCL) and graft versus host disease (GvHD). However, only few studies investigated the practical aspects of ECP.METHODS: Treatment protocols of 2038 ECP procedures in 52 patients (CTCL, n = 29; GvHD, n = 15; other, n = 8) were evaluated. The patients were treated with the UVAR® XTS™ ECP system (Therakos, Inc. Johnson & Johnson, Raritan, NJ, USA) between 2001 and 2010. All patients started with a peripheral venous access. During the course of treatment 7 patients were treated via a port and 4 via a central venous catheter.RESULTS: In all, 1765 (86.6%) treatments were performed with a peripheral venous access; 239 (11.7%) ECPs were done via a port and 34 (1.7%) via a central venous catheter. The peripheral venous access showed a higher flow rate and longer photoactivation time. ECPs via port lead to higher UV-irradiated volumes, longer treatment times and higher differences in systolic blood pressure. The following side effects were observed: being unwell (n = 13), hypo- (n = 13) and hypertension (n = 7), vertigo (n = 4), headache (n = 4), shortness of breath (n = 4), fever (n = 3) and metallic taste (n = 3). Technical complications such as problems with venous access (9.6%) occurred in 385 (18.9%) treatments.CONCLUSIONS: Peripheral venous access should be preferred for ECP treatments.
KW - English Abstract
KW - Journal Article
U2 - 10.1007/s00105-018-4327-y
DO - 10.1007/s00105-018-4327-y
M3 - SCORING: Zeitschriftenaufsatz
C2 - 30627743
VL - 70
SP - 193
EP - 203
JO - HAUTARZT
JF - HAUTARZT
SN - 0017-8470
IS - 3
ER -
