Unimodal and cross-modal plasticity in the 'deaf' auditory cortex.
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Unimodal and cross-modal plasticity in the 'deaf' auditory cortex. / Král, Andrej.
In: INT J AUDIOL, Vol. 46, No. 9, 9, 2007, p. 479-493.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Unimodal and cross-modal plasticity in the 'deaf' auditory cortex.
AU - Král, Andrej
PY - 2007
Y1 - 2007
N2 - Congenital auditory deprivation leads to deficits in the auditory cortex. The present review focuses on central aspects of auditory deprivation: development, plasticity, corticocortical interactions, and cross-modal reorganization. We compile imaging data from human subjects, electroencephalographic data from cochlear implanted children, and animal research on congenital deafness. Behavioral, electroencephalographic, and imaging data in humans correspond well to data behavioral and neurophysiological data obtained from congenitally deaf cats. The available data indicate that auditory deprivation leads to 'decoupling' of the primary auditory cortex from cognitive modulation of higher-order auditory areas. Higher-order auditory areas undergo a strong cross-modal reorganization and take-over new functions. Due to these and other deficits of intrinsic microcircuitry, the cortical column can not integrate bottom-up and top-down influences in deaf auditory cortex. In the ultimate consequence perceptual learning is compromised, resulting in sensitive periods.
AB - Congenital auditory deprivation leads to deficits in the auditory cortex. The present review focuses on central aspects of auditory deprivation: development, plasticity, corticocortical interactions, and cross-modal reorganization. We compile imaging data from human subjects, electroencephalographic data from cochlear implanted children, and animal research on congenital deafness. Behavioral, electroencephalographic, and imaging data in humans correspond well to data behavioral and neurophysiological data obtained from congenitally deaf cats. The available data indicate that auditory deprivation leads to 'decoupling' of the primary auditory cortex from cognitive modulation of higher-order auditory areas. Higher-order auditory areas undergo a strong cross-modal reorganization and take-over new functions. Due to these and other deficits of intrinsic microcircuitry, the cortical column can not integrate bottom-up and top-down influences in deaf auditory cortex. In the ultimate consequence perceptual learning is compromised, resulting in sensitive periods.
M3 - SCORING: Zeitschriftenaufsatz
VL - 46
SP - 479
EP - 493
JO - INT J AUDIOL
JF - INT J AUDIOL
SN - 1499-2027
IS - 9
M1 - 9
ER -
