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Unilateral and bilateral neck SIB for head and neck cancer patients: Intensity-modulated proton therapy, tomotherapy, and RapidArc

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Unilateral and bilateral neck SIB for head and neck cancer patients: Intensity-modulated proton therapy, tomotherapy, and RapidArc. / Stromberger, Carmen; Cozzi, Luca; Budach, Volker; Fogliata, Antonella; Ghadjar, Pirus; Wlodarczyk, Waldemar; Jamil, Basil; Raguse, Jan D; Böttcher, Arne; Marnitz, Simone.

In: STRAHLENTHER ONKOL, Vol. 192, No. 4, 04.2016, p. 232-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stromberger, C, Cozzi, L, Budach, V, Fogliata, A, Ghadjar, P, Wlodarczyk, W, Jamil, B, Raguse, JD, Böttcher, A & Marnitz, S 2016, 'Unilateral and bilateral neck SIB for head and neck cancer patients: Intensity-modulated proton therapy, tomotherapy, and RapidArc', STRAHLENTHER ONKOL, vol. 192, no. 4, pp. 232-9. https://doi.org/10.1007/s00066-016-0945-4

APA

Stromberger, C., Cozzi, L., Budach, V., Fogliata, A., Ghadjar, P., Wlodarczyk, W., Jamil, B., Raguse, J. D., Böttcher, A., & Marnitz, S. (2016). Unilateral and bilateral neck SIB for head and neck cancer patients: Intensity-modulated proton therapy, tomotherapy, and RapidArc. STRAHLENTHER ONKOL, 192(4), 232-9. https://doi.org/10.1007/s00066-016-0945-4

Vancouver

Stromberger C, Cozzi L, Budach V, Fogliata A, Ghadjar P, Wlodarczyk W et al. Unilateral and bilateral neck SIB for head and neck cancer patients: Intensity-modulated proton therapy, tomotherapy, and RapidArc. STRAHLENTHER ONKOL. 2016 Apr;192(4):232-9. https://doi.org/10.1007/s00066-016-0945-4

Bibtex

@article{24d4e438d7344b2e838c67719c095559,
title = "Unilateral and bilateral neck SIB for head and neck cancer patients: Intensity-modulated proton therapy, tomotherapy, and RapidArc",
abstract = "AIM: To compare simultaneous integrated boost plans for intensity-modulated proton therapy (IMPT), helical tomotherapy (HT), and RapidArc therapy (RA) for patients with head and neck cancer.PATIENTS AND METHODS: A total of 20 patients with squamous cell carcinoma of the head and neck received definitive chemoradiation with bilateral (n = 14) or unilateral (n = 6) neck irradiation and were planned using IMPT, HT, and RA with 54.4, 60.8, and 70.4 GyE/Gy in 32 fractions. Dose distributions, coverage, conformity, homogeneity to planning target volumes (PTV)s and sparing of organs at risk and normal tissue were compared.RESULTS: All unilateral and bilateral plans showed excellent PTV coverage and acceptable dose conformity. For unilateral treatment, IMPT delivered substantially lower mean doses to contralateral salivary glands (< 0.001-1.1 Gy) than both rotational techniques did (parotid gland: 6-10 Gy; submandibular gland: 15-20 Gy). Regarding the sparing of classical organs at risk for bilateral treatment, IMPT and HT were similarly excellent and RA was satisfactory.CONCLUSION: For unilateral neck irradiation, IMPT may minimize the dry mouth risk in this subgroup but showed no advantage over HT for bilateral neck treatment regarding classical organ-at-risk sparing. All methods satisfied modern standards regarding toxicity and excellent target coverage for unilateral and bilateral treatment of head and neck cancer at the planning level.",
keywords = "Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Chemoradiotherapy, Dose Fractionation, Female, Humans, Male, Middle Aged, Neoplasm Staging, Organs at Risk, Otorhinolaryngologic Neoplasms, Proton Therapy, Radiation Injuries, Radiotherapy Planning, Computer-Assisted, Radiotherapy, Conformal, Radiotherapy, High-Energy, Radiotherapy, Intensity-Modulated, Comparative Study, Journal Article",
author = "Carmen Stromberger and Luca Cozzi and Volker Budach and Antonella Fogliata and Pirus Ghadjar and Waldemar Wlodarczyk and Basil Jamil and Raguse, {Jan D} and Arne B{\"o}ttcher and Simone Marnitz",
year = "2016",
month = apr,
doi = "10.1007/s00066-016-0945-4",
language = "English",
volume = "192",
pages = "232--9",
journal = "STRAHLENTHER ONKOL",
issn = "0179-7158",
publisher = "Urban und Vogel",
number = "4",

}

RIS

TY - JOUR

T1 - Unilateral and bilateral neck SIB for head and neck cancer patients: Intensity-modulated proton therapy, tomotherapy, and RapidArc

AU - Stromberger, Carmen

AU - Cozzi, Luca

AU - Budach, Volker

AU - Fogliata, Antonella

AU - Ghadjar, Pirus

AU - Wlodarczyk, Waldemar

AU - Jamil, Basil

AU - Raguse, Jan D

AU - Böttcher, Arne

AU - Marnitz, Simone

PY - 2016/4

Y1 - 2016/4

N2 - AIM: To compare simultaneous integrated boost plans for intensity-modulated proton therapy (IMPT), helical tomotherapy (HT), and RapidArc therapy (RA) for patients with head and neck cancer.PATIENTS AND METHODS: A total of 20 patients with squamous cell carcinoma of the head and neck received definitive chemoradiation with bilateral (n = 14) or unilateral (n = 6) neck irradiation and were planned using IMPT, HT, and RA with 54.4, 60.8, and 70.4 GyE/Gy in 32 fractions. Dose distributions, coverage, conformity, homogeneity to planning target volumes (PTV)s and sparing of organs at risk and normal tissue were compared.RESULTS: All unilateral and bilateral plans showed excellent PTV coverage and acceptable dose conformity. For unilateral treatment, IMPT delivered substantially lower mean doses to contralateral salivary glands (< 0.001-1.1 Gy) than both rotational techniques did (parotid gland: 6-10 Gy; submandibular gland: 15-20 Gy). Regarding the sparing of classical organs at risk for bilateral treatment, IMPT and HT were similarly excellent and RA was satisfactory.CONCLUSION: For unilateral neck irradiation, IMPT may minimize the dry mouth risk in this subgroup but showed no advantage over HT for bilateral neck treatment regarding classical organ-at-risk sparing. All methods satisfied modern standards regarding toxicity and excellent target coverage for unilateral and bilateral treatment of head and neck cancer at the planning level.

AB - AIM: To compare simultaneous integrated boost plans for intensity-modulated proton therapy (IMPT), helical tomotherapy (HT), and RapidArc therapy (RA) for patients with head and neck cancer.PATIENTS AND METHODS: A total of 20 patients with squamous cell carcinoma of the head and neck received definitive chemoradiation with bilateral (n = 14) or unilateral (n = 6) neck irradiation and were planned using IMPT, HT, and RA with 54.4, 60.8, and 70.4 GyE/Gy in 32 fractions. Dose distributions, coverage, conformity, homogeneity to planning target volumes (PTV)s and sparing of organs at risk and normal tissue were compared.RESULTS: All unilateral and bilateral plans showed excellent PTV coverage and acceptable dose conformity. For unilateral treatment, IMPT delivered substantially lower mean doses to contralateral salivary glands (< 0.001-1.1 Gy) than both rotational techniques did (parotid gland: 6-10 Gy; submandibular gland: 15-20 Gy). Regarding the sparing of classical organs at risk for bilateral treatment, IMPT and HT were similarly excellent and RA was satisfactory.CONCLUSION: For unilateral neck irradiation, IMPT may minimize the dry mouth risk in this subgroup but showed no advantage over HT for bilateral neck treatment regarding classical organ-at-risk sparing. All methods satisfied modern standards regarding toxicity and excellent target coverage for unilateral and bilateral treatment of head and neck cancer at the planning level.

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Squamous Cell

KW - Chemoradiotherapy

KW - Dose Fractionation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Organs at Risk

KW - Otorhinolaryngologic Neoplasms

KW - Proton Therapy

KW - Radiation Injuries

KW - Radiotherapy Planning, Computer-Assisted

KW - Radiotherapy, Conformal

KW - Radiotherapy, High-Energy

KW - Radiotherapy, Intensity-Modulated

KW - Comparative Study

KW - Journal Article

U2 - 10.1007/s00066-016-0945-4

DO - 10.1007/s00066-016-0945-4

M3 - SCORING: Journal article

C2 - 26852243

VL - 192

SP - 232

EP - 239

JO - STRAHLENTHER ONKOL

JF - STRAHLENTHER ONKOL

SN - 0179-7158

IS - 4

ER -