Umbilical cord blood versus unrelated donor transplantation in adults with primary refractory or relapsed acute myeloid leukemia: a report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the EBMT
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Umbilical cord blood versus unrelated donor transplantation in adults with primary refractory or relapsed acute myeloid leukemia: a report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the EBMT. / Baron, Frédéric; Labopin, Myriam; Ruggeri, Annalisa; Ehninger, Gerhard; Bonifazi, Fransesca; Stelljes, Matthias; Sanz, Jaime; Stuhler, Gernot; Bosi, Alberto; Kröger, Nicolaus; Van Lint, Maria Teresa; Ganser, Arnold; Forcade, Edouard; Mohty, Mohamad; Gluckman, Eliane; Nagler, Arnon.
In: BLOOD CANCER J, Vol. 9, No. 4, 12.04.2019, p. 46.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Umbilical cord blood versus unrelated donor transplantation in adults with primary refractory or relapsed acute myeloid leukemia: a report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the EBMT
AU - Baron, Frédéric
AU - Labopin, Myriam
AU - Ruggeri, Annalisa
AU - Ehninger, Gerhard
AU - Bonifazi, Fransesca
AU - Stelljes, Matthias
AU - Sanz, Jaime
AU - Stuhler, Gernot
AU - Bosi, Alberto
AU - Kröger, Nicolaus
AU - Van Lint, Maria Teresa
AU - Ganser, Arnold
AU - Forcade, Edouard
AU - Mohty, Mohamad
AU - Gluckman, Eliane
AU - Nagler, Arnon
PY - 2019/4/12
Y1 - 2019/4/12
N2 - The role of umbilical cord blood transplantation (CBT) in acute myeloid leukemia (AML) patients with active disease at allogeneic hematopoietic cell transplantation (allo-HCT) remains poorly investigated. In this study, we compared transplantation outcomes of 2963 patients with primary refractory or relapsed AML given CBT, 10/10 HLA-matched UD, or 9/10 HLA-matched UD allo-HCT from 2004 to 2015 at EBMT-affiliated centers. Neutrophil engraftment and complete remission rates in CBT, UD 10/10, and UD 9/10 recipients were 75 and 48%, 93 and 69%, and 93 and 70%, respectively. In multivariate Cox analyses, in comparison with CBT (n = 285), UD 10/10 recipients (n = 2001) had a lower incidence of relapse (HR = 0.7, P = 0.001), a lower incidence of non relapse mortality (HR = 0.6, P < 0.001), better GVHD-free and leukemia-free survival (GRFS, HR = 0.8, P < 0.001) and better survival (HR = 0.6, P < 0.001). Further, in comparison with CBT, 9/10 UD recipients (n = 677) also had a lower incidence of relapse (HR = 0.8, P = 0.02), a lower incidence of nonrelapse mortality (HR = 0.7, P = 0.008), better GRFS (HR = 0.8, P = 0.01) and better survival (HR = 0.7, P < 0.001). In summary, these data suggest that in AML patients with active disease at transplantation, allo-HCT with UD results in better transplantation outcomes than CBT.
AB - The role of umbilical cord blood transplantation (CBT) in acute myeloid leukemia (AML) patients with active disease at allogeneic hematopoietic cell transplantation (allo-HCT) remains poorly investigated. In this study, we compared transplantation outcomes of 2963 patients with primary refractory or relapsed AML given CBT, 10/10 HLA-matched UD, or 9/10 HLA-matched UD allo-HCT from 2004 to 2015 at EBMT-affiliated centers. Neutrophil engraftment and complete remission rates in CBT, UD 10/10, and UD 9/10 recipients were 75 and 48%, 93 and 69%, and 93 and 70%, respectively. In multivariate Cox analyses, in comparison with CBT (n = 285), UD 10/10 recipients (n = 2001) had a lower incidence of relapse (HR = 0.7, P = 0.001), a lower incidence of non relapse mortality (HR = 0.6, P < 0.001), better GVHD-free and leukemia-free survival (GRFS, HR = 0.8, P < 0.001) and better survival (HR = 0.6, P < 0.001). Further, in comparison with CBT, 9/10 UD recipients (n = 677) also had a lower incidence of relapse (HR = 0.8, P = 0.02), a lower incidence of nonrelapse mortality (HR = 0.7, P = 0.008), better GRFS (HR = 0.8, P = 0.01) and better survival (HR = 0.7, P < 0.001). In summary, these data suggest that in AML patients with active disease at transplantation, allo-HCT with UD results in better transplantation outcomes than CBT.
U2 - 10.1038/s41408-019-0204-x
DO - 10.1038/s41408-019-0204-x
M3 - SCORING: Journal article
C2 - 30979868
VL - 9
SP - 46
JO - BLOOD CANCER J
JF - BLOOD CANCER J
SN - 2044-5385
IS - 4
ER -