Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease.
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Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease. / Herzog, Jan; Volkmann, Jens; Krack, Paul; Kopper, Florian; Pötter, Monika; Lorenz, Delia; Steinbach, Meike; Klebe, Stefan; Hamel, Wolfgang; Schrader, Bettina; Weinert, Dieter; Müller, Dieter; Mehdorn, Hubertus M; Deuschl, Günther.
In: MOVEMENT DISORD, Vol. 18, No. 11, 11, 2003, p. 1332-1337.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease.
AU - Herzog, Jan
AU - Volkmann, Jens
AU - Krack, Paul
AU - Kopper, Florian
AU - Pötter, Monika
AU - Lorenz, Delia
AU - Steinbach, Meike
AU - Klebe, Stefan
AU - Hamel, Wolfgang
AU - Schrader, Bettina
AU - Weinert, Dieter
AU - Müller, Dieter
AU - Mehdorn, Hubertus M
AU - Deuschl, Günther
PY - 2003
Y1 - 2003
N2 - We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow-up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow-up, STN-DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN-DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary.
AB - We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow-up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow-up, STN-DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN-DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary.
M3 - SCORING: Journal article
VL - 18
SP - 1332
EP - 1337
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 11
M1 - 11
ER -
