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Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression

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Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression. / Schramm, Elisabeth; Kriston, Levente; Elsaesser, Moritz; Fangmeier, Thomas; Meister, Ramona; Bausch, Paul; Zobel, Ingo; Bailer, Josef; Wambach, Katrin; Backenstrass, Matthias; Klein, Jan Philipp; Schoepf, Dieter; Schnell, Knut; Gumz, Antje; Löwe, Bernd; Walter, Henrik; Wolf, Markus; Domschke, Katharina; Berger, Mathias; Hautzinger, Martin; Härter, Martin.

In: PSYCHOTHER PSYCHOSOM, Vol. 88, No. 3, 2019, p. 154-164.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schramm, E, Kriston, L, Elsaesser, M, Fangmeier, T, Meister, R, Bausch, P, Zobel, I, Bailer, J, Wambach, K, Backenstrass, M, Klein, JP, Schoepf, D, Schnell, K, Gumz, A, Löwe, B, Walter, H, Wolf, M, Domschke, K, Berger, M, Hautzinger, M & Härter, M 2019, 'Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression', PSYCHOTHER PSYCHOSOM, vol. 88, no. 3, pp. 154-164. https://doi.org/10.1159/000500189

APA

Schramm, E., Kriston, L., Elsaesser, M., Fangmeier, T., Meister, R., Bausch, P., Zobel, I., Bailer, J., Wambach, K., Backenstrass, M., Klein, J. P., Schoepf, D., Schnell, K., Gumz, A., Löwe, B., Walter, H., Wolf, M., Domschke, K., Berger, M., ... Härter, M. (2019). Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression. PSYCHOTHER PSYCHOSOM, 88(3), 154-164. https://doi.org/10.1159/000500189

Vancouver

Schramm E, Kriston L, Elsaesser M, Fangmeier T, Meister R, Bausch P et al. Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression. PSYCHOTHER PSYCHOSOM. 2019;88(3):154-164. https://doi.org/10.1159/000500189

Bibtex

@article{705fdbb0d0ff43caa07b6eaad7dbbb13,
title = "Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression",
abstract = "BACKGROUND: Evidence on the long-term efficacy of psychotherapeutic approaches for chronic depression is scarce.OBJECTIVE: To evaluate the effects of the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) compared to Supportive Psychotherapy (SP) 1 year and 2 years after treatment termination.METHODS: In this study, we present 1- and 2-year follow-up assessments of a prospective, multicenter, evaluator-blinded, randomized clinical trial of outpatients with early-onset chronic major depression (n = 268). The initial treatment included 32 sessions of CBASP or SP over 48 weeks. The primary outcome was the rate of {"}well weeks{"} (Longitudinal Interval Follow-Up Evaluation; no/minimal symptoms) after 1 year and 2 years. The secondary outcomes were, among others, clinician- and self-rated depressive symptoms, response/remission rates, and quality of life.RESULTS: Of the 268 randomized patients, 207 (77%) participated in the follow-up. In the intention-to-treat analysis, there was no statistically significant difference between CBASP and SP patients in experiencing well weeks (CBASP: mean [SD] of 48.6 [36.9] weeks; SP: 39.0 [34.8]; rate ratio 1.26, 95% CI 0.99-1.59, p = 0.057, d = 0.18) and in remission rates (CBASP: 1 year 40%, 2 years 40.2%; SP: 1 year 28.9%, 2 years 33%) in the 2 years after treatment. Statistically significant effects were found in favor of CBASP 1 year after treatment termination regarding the rate of well weeks, self-rated depressive symptoms, and depression-related quality of life.CONCLUSIONS: CBASP lost its superiority over SP at some point between the first and the second year. This suggests the necessity of maintenance treatment for early-onset chronically depressed patients remitted with CBASP during the acute therapy phase, as well as the sequential integration of other treatment strategies, including medication for those who did not reach remission.",
author = "Elisabeth Schramm and Levente Kriston and Moritz Elsaesser and Thomas Fangmeier and Ramona Meister and Paul Bausch and Ingo Zobel and Josef Bailer and Katrin Wambach and Matthias Backenstrass and Klein, {Jan Philipp} and Dieter Schoepf and Knut Schnell and Antje Gumz and Bernd L{\"o}we and Henrik Walter and Markus Wolf and Katharina Domschke and Mathias Berger and Martin Hautzinger and Martin H{\"a}rter",
note = "{\textcopyright} 2019 S. Karger AG, Basel.",
year = "2019",
doi = "10.1159/000500189",
language = "English",
volume = "88",
pages = "154--164",
journal = "PSYCHOTHER PSYCHOSOM",
issn = "0033-3190",
publisher = "S. Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression

AU - Schramm, Elisabeth

AU - Kriston, Levente

AU - Elsaesser, Moritz

AU - Fangmeier, Thomas

AU - Meister, Ramona

AU - Bausch, Paul

AU - Zobel, Ingo

AU - Bailer, Josef

AU - Wambach, Katrin

AU - Backenstrass, Matthias

AU - Klein, Jan Philipp

AU - Schoepf, Dieter

AU - Schnell, Knut

AU - Gumz, Antje

AU - Löwe, Bernd

AU - Walter, Henrik

AU - Wolf, Markus

AU - Domschke, Katharina

AU - Berger, Mathias

AU - Hautzinger, Martin

AU - Härter, Martin

N1 - © 2019 S. Karger AG, Basel.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Evidence on the long-term efficacy of psychotherapeutic approaches for chronic depression is scarce.OBJECTIVE: To evaluate the effects of the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) compared to Supportive Psychotherapy (SP) 1 year and 2 years after treatment termination.METHODS: In this study, we present 1- and 2-year follow-up assessments of a prospective, multicenter, evaluator-blinded, randomized clinical trial of outpatients with early-onset chronic major depression (n = 268). The initial treatment included 32 sessions of CBASP or SP over 48 weeks. The primary outcome was the rate of "well weeks" (Longitudinal Interval Follow-Up Evaluation; no/minimal symptoms) after 1 year and 2 years. The secondary outcomes were, among others, clinician- and self-rated depressive symptoms, response/remission rates, and quality of life.RESULTS: Of the 268 randomized patients, 207 (77%) participated in the follow-up. In the intention-to-treat analysis, there was no statistically significant difference between CBASP and SP patients in experiencing well weeks (CBASP: mean [SD] of 48.6 [36.9] weeks; SP: 39.0 [34.8]; rate ratio 1.26, 95% CI 0.99-1.59, p = 0.057, d = 0.18) and in remission rates (CBASP: 1 year 40%, 2 years 40.2%; SP: 1 year 28.9%, 2 years 33%) in the 2 years after treatment. Statistically significant effects were found in favor of CBASP 1 year after treatment termination regarding the rate of well weeks, self-rated depressive symptoms, and depression-related quality of life.CONCLUSIONS: CBASP lost its superiority over SP at some point between the first and the second year. This suggests the necessity of maintenance treatment for early-onset chronically depressed patients remitted with CBASP during the acute therapy phase, as well as the sequential integration of other treatment strategies, including medication for those who did not reach remission.

AB - BACKGROUND: Evidence on the long-term efficacy of psychotherapeutic approaches for chronic depression is scarce.OBJECTIVE: To evaluate the effects of the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) compared to Supportive Psychotherapy (SP) 1 year and 2 years after treatment termination.METHODS: In this study, we present 1- and 2-year follow-up assessments of a prospective, multicenter, evaluator-blinded, randomized clinical trial of outpatients with early-onset chronic major depression (n = 268). The initial treatment included 32 sessions of CBASP or SP over 48 weeks. The primary outcome was the rate of "well weeks" (Longitudinal Interval Follow-Up Evaluation; no/minimal symptoms) after 1 year and 2 years. The secondary outcomes were, among others, clinician- and self-rated depressive symptoms, response/remission rates, and quality of life.RESULTS: Of the 268 randomized patients, 207 (77%) participated in the follow-up. In the intention-to-treat analysis, there was no statistically significant difference between CBASP and SP patients in experiencing well weeks (CBASP: mean [SD] of 48.6 [36.9] weeks; SP: 39.0 [34.8]; rate ratio 1.26, 95% CI 0.99-1.59, p = 0.057, d = 0.18) and in remission rates (CBASP: 1 year 40%, 2 years 40.2%; SP: 1 year 28.9%, 2 years 33%) in the 2 years after treatment. Statistically significant effects were found in favor of CBASP 1 year after treatment termination regarding the rate of well weeks, self-rated depressive symptoms, and depression-related quality of life.CONCLUSIONS: CBASP lost its superiority over SP at some point between the first and the second year. This suggests the necessity of maintenance treatment for early-onset chronically depressed patients remitted with CBASP during the acute therapy phase, as well as the sequential integration of other treatment strategies, including medication for those who did not reach remission.

U2 - 10.1159/000500189

DO - 10.1159/000500189

M3 - SCORING: Journal article

C2 - 31121581

VL - 88

SP - 154

EP - 164

JO - PSYCHOTHER PSYCHOSOM

JF - PSYCHOTHER PSYCHOSOM

SN - 0033-3190

IS - 3

ER -