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Two TRPV1 receptor antagonists are effective in two different experimental models of migraine

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Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. / Meents, Jannis E; Hoffmann, Jan; Chaplan, Sandra R; Neeb, Lars; Schuh-Hofer, Sigrid; Wickenden, Alan; Reuter, Uwe.

In: J HEADACHE PAIN, Vol. 16, 24.06.2015, p. Art. 57.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meents, JE, Hoffmann, J, Chaplan, SR, Neeb, L, Schuh-Hofer, S, Wickenden, A & Reuter, U 2015, 'Two TRPV1 receptor antagonists are effective in two different experimental models of migraine', J HEADACHE PAIN, vol. 16, pp. Art. 57. https://doi.org/10.1186/s10194-015-0539-z

APA

Meents, J. E., Hoffmann, J., Chaplan, S. R., Neeb, L., Schuh-Hofer, S., Wickenden, A., & Reuter, U. (2015). Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. J HEADACHE PAIN, 16, Art. 57. https://doi.org/10.1186/s10194-015-0539-z

Vancouver

Meents JE, Hoffmann J, Chaplan SR, Neeb L, Schuh-Hofer S, Wickenden A et al. Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. J HEADACHE PAIN. 2015 Jun 24;16:Art. 57. https://doi.org/10.1186/s10194-015-0539-z

Bibtex

@article{908818b6597c42209a13a9c6e4368f9c,
title = "Two TRPV1 receptor antagonists are effective in two different experimental models of migraine",
abstract = "BACKGROUND: The capsaicin and heat responsive ion channel TRPV1 is expressed on trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine attacks. Here we investigate the efficacy of two TRPV1 channel antagonists in blocking trigeminal activation using two in vivo models of migraine.METHODS: Male Sprague-Dawley rats were used to study the effects of the TRPV1 antagonists JNJ-38893777 and JNJ-17203212 on trigeminal activation. Expression of the immediate early gene c-fos was measured following intracisternal application of inflammatory soup. In a second model, CGRP release into the external jugular vein was determined following injection of capsaicin into the carotid artery.RESULTS: Inflammatory up-regulation of c-fos in the trigeminal brain stem complex was dose-dependently and significantly reduced by both TRPV1 antagonists. Capsaicin-induced CGRP release was attenuated by JNJ-38893777 only in higher dosage. JNJ-17203212 was effective in all doses and fully abolished CGRP release in a time and dose-dependent manner.CONCLUSION: Our results describe two TRPV1 antagonists that are effective in two in vivo models of migraine. These results suggest that TRPV1 may play a role in the pathophysiological mechanisms, which are relevant to migraine.",
author = "Meents, {Jannis E} and Jan Hoffmann and Chaplan, {Sandra R} and Lars Neeb and Sigrid Schuh-Hofer and Alan Wickenden and Uwe Reuter",
year = "2015",
month = jun,
day = "24",
doi = "10.1186/s10194-015-0539-z",
language = "English",
volume = "16",
pages = "Art. 57",
journal = "J HEADACHE PAIN",
issn = "1129-2369",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Two TRPV1 receptor antagonists are effective in two different experimental models of migraine

AU - Meents, Jannis E

AU - Hoffmann, Jan

AU - Chaplan, Sandra R

AU - Neeb, Lars

AU - Schuh-Hofer, Sigrid

AU - Wickenden, Alan

AU - Reuter, Uwe

PY - 2015/6/24

Y1 - 2015/6/24

N2 - BACKGROUND: The capsaicin and heat responsive ion channel TRPV1 is expressed on trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine attacks. Here we investigate the efficacy of two TRPV1 channel antagonists in blocking trigeminal activation using two in vivo models of migraine.METHODS: Male Sprague-Dawley rats were used to study the effects of the TRPV1 antagonists JNJ-38893777 and JNJ-17203212 on trigeminal activation. Expression of the immediate early gene c-fos was measured following intracisternal application of inflammatory soup. In a second model, CGRP release into the external jugular vein was determined following injection of capsaicin into the carotid artery.RESULTS: Inflammatory up-regulation of c-fos in the trigeminal brain stem complex was dose-dependently and significantly reduced by both TRPV1 antagonists. Capsaicin-induced CGRP release was attenuated by JNJ-38893777 only in higher dosage. JNJ-17203212 was effective in all doses and fully abolished CGRP release in a time and dose-dependent manner.CONCLUSION: Our results describe two TRPV1 antagonists that are effective in two in vivo models of migraine. These results suggest that TRPV1 may play a role in the pathophysiological mechanisms, which are relevant to migraine.

AB - BACKGROUND: The capsaicin and heat responsive ion channel TRPV1 is expressed on trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine attacks. Here we investigate the efficacy of two TRPV1 channel antagonists in blocking trigeminal activation using two in vivo models of migraine.METHODS: Male Sprague-Dawley rats were used to study the effects of the TRPV1 antagonists JNJ-38893777 and JNJ-17203212 on trigeminal activation. Expression of the immediate early gene c-fos was measured following intracisternal application of inflammatory soup. In a second model, CGRP release into the external jugular vein was determined following injection of capsaicin into the carotid artery.RESULTS: Inflammatory up-regulation of c-fos in the trigeminal brain stem complex was dose-dependently and significantly reduced by both TRPV1 antagonists. Capsaicin-induced CGRP release was attenuated by JNJ-38893777 only in higher dosage. JNJ-17203212 was effective in all doses and fully abolished CGRP release in a time and dose-dependent manner.CONCLUSION: Our results describe two TRPV1 antagonists that are effective in two in vivo models of migraine. These results suggest that TRPV1 may play a role in the pathophysiological mechanisms, which are relevant to migraine.

U2 - 10.1186/s10194-015-0539-z

DO - 10.1186/s10194-015-0539-z

M3 - SCORING: Journal article

C2 - 26109436

VL - 16

SP - Art. 57

JO - J HEADACHE PAIN

JF - J HEADACHE PAIN

SN - 1129-2369

ER -