Twinning to reduce research and innovation inequalities in paediatric solid tumours across Europe
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Twinning to reduce research and innovation inequalities in paediatric solid tumours across Europe. / Rascon, Jelena; Blackute, Renata; Cerkauskiene, Alma; Taschner-Mandl, Sabine; Andrade, Nuno; Planinic, Adriana; Rutkowski, Stefan; Schüller, Ulrich; Nysom, Karsten; Tuckuviene, Ruta; Brok, Jesper; Schmiegelow, Kjeld; van den Heuvel-Eibrink, Marry M.; van der Perk, M.E. Madeleine; Haupt, Riccardo; Muraca, Monica; Saraceno, Davide; Geoerger, Birgit; Manuzi, Giorgia; Ladenstein, Ruth.
In: EJC Paediatric Oncology, Vol. 3, 100153, 2024.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Twinning to reduce research and innovation inequalities in paediatric solid tumours across Europe
AU - Rascon, Jelena
AU - Blackute, Renata
AU - Cerkauskiene, Alma
AU - Taschner-Mandl, Sabine
AU - Andrade, Nuno
AU - Planinic, Adriana
AU - Rutkowski, Stefan
AU - Schüller, Ulrich
AU - Nysom, Karsten
AU - Tuckuviene, Ruta
AU - Brok, Jesper
AU - Schmiegelow, Kjeld
AU - van den Heuvel-Eibrink, Marry M.
AU - van der Perk, M.E. Madeleine
AU - Haupt, Riccardo
AU - Muraca, Monica
AU - Saraceno, Davide
AU - Geoerger, Birgit
AU - Manuzi, Giorgia
AU - Ladenstein, Ruth
PY - 2024
Y1 - 2024
N2 - Inequalities in research and innovations affect childhood cancer survival across Europe. Vilnius University Hospital Santaros Klinikos (VULSK, the coordinator) and eight research-intensive institutions from seven European countries implemented the TREL project (Twinning in Research and Education to improve survival in childhood solid tumours in Lithuania) supported by the Horizon 2020 Widening programme. TREL aimed to enhance translational, clinical, and survivorship research in paediatric CNS, neuroblastoma, and renal tumours to improve future treatment outcomes in Lithuania. From January 2021 to December 2023, 49 VULSK professionals and 55 peers from partner institutions collaborated in this twinning program. Achievements after three years were: nine educational events, the initiation of basic and clinical research on fertility preservation, ten VULSK researchers joining international research groups, six signed agreements to participate in international academic clinical trials and the implementation of the European Survivorship Passport. Thirty patients received individual treatment recommendations following multidisciplinary discussions with experts from partner institutions. Twenty-five rare genetic variants were classified by the twinning bioinformatician teams with direct consequences on patient management. In conclusion, coordination of the Horizon 2020 project enhanced VULKS’s research capacities, networking channels and attractiveness for industry and academia-initiated innovative actions that will improve survival rates in the long run.
AB - Inequalities in research and innovations affect childhood cancer survival across Europe. Vilnius University Hospital Santaros Klinikos (VULSK, the coordinator) and eight research-intensive institutions from seven European countries implemented the TREL project (Twinning in Research and Education to improve survival in childhood solid tumours in Lithuania) supported by the Horizon 2020 Widening programme. TREL aimed to enhance translational, clinical, and survivorship research in paediatric CNS, neuroblastoma, and renal tumours to improve future treatment outcomes in Lithuania. From January 2021 to December 2023, 49 VULSK professionals and 55 peers from partner institutions collaborated in this twinning program. Achievements after three years were: nine educational events, the initiation of basic and clinical research on fertility preservation, ten VULSK researchers joining international research groups, six signed agreements to participate in international academic clinical trials and the implementation of the European Survivorship Passport. Thirty patients received individual treatment recommendations following multidisciplinary discussions with experts from partner institutions. Twenty-five rare genetic variants were classified by the twinning bioinformatician teams with direct consequences on patient management. In conclusion, coordination of the Horizon 2020 project enhanced VULKS’s research capacities, networking channels and attractiveness for industry and academia-initiated innovative actions that will improve survival rates in the long run.
KW - Twinning
KW - Research
KW - Inequalities
KW - Paediatric oncology
KW - Horizon 2020
KW - Survival
U2 - 10.1016/j.ejcped.2024.100153
DO - 10.1016/j.ejcped.2024.100153
M3 - SCORING: Zeitschriftenaufsatz
VL - 3
M1 - 100153
ER -
