Tumour volume and high grade tumour volume are the best predictors of pathologic stage and biochemical recurrence after radical prostatectomy.
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Tumour volume and high grade tumour volume are the best predictors of pathologic stage and biochemical recurrence after radical prostatectomy. / Chun, Felix; Briganti, Alberto; Jeldres, Claudio; Gallina, Andrea; Erbersdobler, Andreas; Schlomm, Thorsten; Walz, Jochen; Eichelberg, Christian; Salomon, Georg; Haese, Alexander; Eichelberg, Eike; Ahyai, Sascha; Bénard, François; Huland, Hartwig; Graefen, Markus; Karakiewicz, Pierre I.
In: EUR J CANCER, Vol. 43, No. 3, 3, 2007, p. 536-543.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Tumour volume and high grade tumour volume are the best predictors of pathologic stage and biochemical recurrence after radical prostatectomy.
AU - Chun, Felix
AU - Briganti, Alberto
AU - Jeldres, Claudio
AU - Gallina, Andrea
AU - Erbersdobler, Andreas
AU - Schlomm, Thorsten
AU - Walz, Jochen
AU - Eichelberg, Christian
AU - Salomon, Georg
AU - Haese, Alexander
AU - Eichelberg, Eike
AU - Ahyai, Sascha
AU - Bénard, François
AU - Huland, Hartwig
AU - Graefen, Markus
AU - Karakiewicz, Pierre I
PY - 2007
Y1 - 2007
N2 - INTRODUCTION: Our goal was to examine to what extent tumour volume (TV) and percentage of high grade tumour volume (%HGTV) affect the rate of positive surgical margins and the rate of biochemical recurrence after radical prostatectomy. MATERIALS AND METHODS: TV and %HGTV were routinely planimetrically quantified in a cohort of 780 consecutive patients. Mean follow-up was 46.7 months. Multivariable regression models addressed two separate endpoints: positive surgical margins and biochemical recurrence. The increase in model predictive accuracy related to the addition of TV and %HGTV to radical prostatectomy stage and grade was assessed, after 200 bootstrap resamples to reduce overfit bias. RESULTS: In multivariable logistic regression models addressing positive surgical margins rate, predictive accuracy increased by 1.9% (p
AB - INTRODUCTION: Our goal was to examine to what extent tumour volume (TV) and percentage of high grade tumour volume (%HGTV) affect the rate of positive surgical margins and the rate of biochemical recurrence after radical prostatectomy. MATERIALS AND METHODS: TV and %HGTV were routinely planimetrically quantified in a cohort of 780 consecutive patients. Mean follow-up was 46.7 months. Multivariable regression models addressed two separate endpoints: positive surgical margins and biochemical recurrence. The increase in model predictive accuracy related to the addition of TV and %HGTV to radical prostatectomy stage and grade was assessed, after 200 bootstrap resamples to reduce overfit bias. RESULTS: In multivariable logistic regression models addressing positive surgical margins rate, predictive accuracy increased by 1.9% (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 43
SP - 536
EP - 543
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
IS - 3
M1 - 3
ER -