Research ExplorerPublicationsTumour hypoxia promotes melanoma growth and metastasis via H...

Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages

Standard

Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages. / Huber, Roman; Meier, Barbara; Otsuka, Atsushi; Fenini, Gabriele; Satoh, Takashi; Gehrke, Samuel; Widmer, Daniel; Levesque, Mitchell P; Mangana, Joanna; Kerl, Katrin; Gebhardt, Christoffer; Fujii, Hiroko; Nakashima, Chisa; Nonomura, Yumi; Kabashima, Kenji; Dummer, Reinhard; Contassot, Emmanuel; French, Lars E.

In: SCI REP-UK, Vol. 6, 18.07.2016, p. 29914.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Huber, R, Meier, B, Otsuka, A, Fenini, G, Satoh, T, Gehrke, S, Widmer, D, Levesque, MP, Mangana, J, Kerl, K, Gebhardt, C, Fujii, H, Nakashima, C, Nonomura, Y, Kabashima, K, Dummer, R, Contassot, E & French, LE 2016, 'Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages', SCI REP-UK, vol. 6, pp. 29914. https://doi.org/10.1038/srep29914

APA

Huber, R., Meier, B., Otsuka, A., Fenini, G., Satoh, T., Gehrke, S., Widmer, D., Levesque, M. P., Mangana, J., Kerl, K., Gebhardt, C., Fujii, H., Nakashima, C., Nonomura, Y., Kabashima, K., Dummer, R., Contassot, E., & French, L. E. (2016). Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages. SCI REP-UK, 6, 29914. https://doi.org/10.1038/srep29914

Vancouver

Huber R, Meier B, Otsuka A, Fenini G, Satoh T, Gehrke S et al. Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages. SCI REP-UK. 2016 Jul 18;6:29914. https://doi.org/10.1038/srep29914

Bibtex

@article{cb59b1f21d7142d4be5969c09a91e742,
title = "Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages",
abstract = "Hypoxia is a hallmark of cancer that is strongly associated with invasion, metastasis, resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses and promotes the accumulation of macrophages in the tumour microenvironment. However, the signals linking tumour hypoxia to tumour-associated macrophage recruitment and tumour promotion are incompletely understood. Here we show that the damage-associated molecular pattern High-Mobility Group Box 1 protein (HMGB1) is released by melanoma tumour cells as a consequence of hypoxia and promotes M2-like tumour-associated macrophage accumulation and an IL-10 rich milieu within the tumour. Furthermore, we demonstrate that HMGB1 drives IL-10 production in M2-like macrophages by selectively signalling through the Receptor for Advanced Glycation End products (RAGE). Finally, we show that HMGB1 has an important role in murine B16 melanoma growth and metastasis, whereas in humans its serum concentration is significantly increased in metastatic melanoma. Collectively, our findings identify a mechanism by which hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target.",
keywords = "Journal Article",
author = "Roman Huber and Barbara Meier and Atsushi Otsuka and Gabriele Fenini and Takashi Satoh and Samuel Gehrke and Daniel Widmer and Levesque, {Mitchell P} and Joanna Mangana and Katrin Kerl and Christoffer Gebhardt and Hiroko Fujii and Chisa Nakashima and Yumi Nonomura and Kenji Kabashima and Reinhard Dummer and Emmanuel Contassot and French, {Lars E}",
year = "2016",
month = jul,
day = "18",
doi = "10.1038/srep29914",
language = "English",
volume = "6",
pages = "29914",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages

AU - Huber, Roman

AU - Meier, Barbara

AU - Otsuka, Atsushi

AU - Fenini, Gabriele

AU - Satoh, Takashi

AU - Gehrke, Samuel

AU - Widmer, Daniel

AU - Levesque, Mitchell P

AU - Mangana, Joanna

AU - Kerl, Katrin

AU - Gebhardt, Christoffer

AU - Fujii, Hiroko

AU - Nakashima, Chisa

AU - Nonomura, Yumi

AU - Kabashima, Kenji

AU - Dummer, Reinhard

AU - Contassot, Emmanuel

AU - French, Lars E

PY - 2016/7/18

Y1 - 2016/7/18

N2 - Hypoxia is a hallmark of cancer that is strongly associated with invasion, metastasis, resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses and promotes the accumulation of macrophages in the tumour microenvironment. However, the signals linking tumour hypoxia to tumour-associated macrophage recruitment and tumour promotion are incompletely understood. Here we show that the damage-associated molecular pattern High-Mobility Group Box 1 protein (HMGB1) is released by melanoma tumour cells as a consequence of hypoxia and promotes M2-like tumour-associated macrophage accumulation and an IL-10 rich milieu within the tumour. Furthermore, we demonstrate that HMGB1 drives IL-10 production in M2-like macrophages by selectively signalling through the Receptor for Advanced Glycation End products (RAGE). Finally, we show that HMGB1 has an important role in murine B16 melanoma growth and metastasis, whereas in humans its serum concentration is significantly increased in metastatic melanoma. Collectively, our findings identify a mechanism by which hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target.

AB - Hypoxia is a hallmark of cancer that is strongly associated with invasion, metastasis, resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses and promotes the accumulation of macrophages in the tumour microenvironment. However, the signals linking tumour hypoxia to tumour-associated macrophage recruitment and tumour promotion are incompletely understood. Here we show that the damage-associated molecular pattern High-Mobility Group Box 1 protein (HMGB1) is released by melanoma tumour cells as a consequence of hypoxia and promotes M2-like tumour-associated macrophage accumulation and an IL-10 rich milieu within the tumour. Furthermore, we demonstrate that HMGB1 drives IL-10 production in M2-like macrophages by selectively signalling through the Receptor for Advanced Glycation End products (RAGE). Finally, we show that HMGB1 has an important role in murine B16 melanoma growth and metastasis, whereas in humans its serum concentration is significantly increased in metastatic melanoma. Collectively, our findings identify a mechanism by which hypoxia affects tumour growth and metastasis in melanoma and depict HMGB1 as a potential therapeutic target.

KW - Journal Article

U2 - 10.1038/srep29914

DO - 10.1038/srep29914

M3 - SCORING: Journal article

C2 - 27426915

VL - 6

SP - 29914

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -