Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer.
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Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer. / Zellweger, Tobias; Günther, Sarah; Zlobec, Inti; Savic, Spasenija; Sauter, Guido; Moch, Holger; Mattarelli, Gianfranco; Eichenberger, Tobias; Curschellas, Enrico; Rüfenacht, Hansjörg; Bachmann, Alexander; Gasser, Thomas C; Mihatsch, Michael J; Bubendorf, Lukas.
In: INT J CANCER, Vol. 124, No. 9, 9, 2009, p. 2116-2123.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer.
AU - Zellweger, Tobias
AU - Günther, Sarah
AU - Zlobec, Inti
AU - Savic, Spasenija
AU - Sauter, Guido
AU - Moch, Holger
AU - Mattarelli, Gianfranco
AU - Eichenberger, Tobias
AU - Curschellas, Enrico
AU - Rüfenacht, Hansjörg
AU - Bachmann, Alexander
AU - Gasser, Thomas C
AU - Mihatsch, Michael J
AU - Bubendorf, Lukas
PY - 2009
Y1 - 2009
N2 - Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinical stage T1c and 23% with T2) who subsequently underwent radical prostatectomy was prospectively analysed for Gleason score, number and percentage of positive cores (NPC, PPC), total percentage of biopsy tissue with tumour (TPT), maximum tumour percentage per core (MTP), and expression of Ki67, Bcl-2 and p53. All biopsy features were significantly associated with at least one feature of the radical prostatectomy specimen. pT stage was independently predicted by PSA, seminal vesicle invasion by Ki67 LI, positive margins by PSA and MTP, large tumour diameter by PSA and PPC, and Gleason score by biopsy Gleason score, MTP, and Ki67 LI, respectively. Biopsy Gleason score, NPC (1 vs. >1), TPT (or=7%), and Ki67 LI (or=10%) were significant predictors of biochemical recurrence after radical prostatectomy (p <0.01, each). KI67 LI was the only independent prognostic factor in case of a low TPT (
AB - Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinical stage T1c and 23% with T2) who subsequently underwent radical prostatectomy was prospectively analysed for Gleason score, number and percentage of positive cores (NPC, PPC), total percentage of biopsy tissue with tumour (TPT), maximum tumour percentage per core (MTP), and expression of Ki67, Bcl-2 and p53. All biopsy features were significantly associated with at least one feature of the radical prostatectomy specimen. pT stage was independently predicted by PSA, seminal vesicle invasion by Ki67 LI, positive margins by PSA and MTP, large tumour diameter by PSA and PPC, and Gleason score by biopsy Gleason score, MTP, and Ki67 LI, respectively. Biopsy Gleason score, NPC (1 vs. >1), TPT (or=7%), and Ki67 LI (or=10%) were significant predictors of biochemical recurrence after radical prostatectomy (p <0.01, each). KI67 LI was the only independent prognostic factor in case of a low TPT (
M3 - SCORING: Zeitschriftenaufsatz
VL - 124
SP - 2116
EP - 2123
JO - INT J CANCER
JF - INT J CANCER
SN - 0020-7136
IS - 9
M1 - 9
ER -
