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Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins

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Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins. / Meyer, Christian P; Hansen, Jens; Boehm, Katharina; Tilki, Derya; Abdollah, Firas; Trinh, Quoc-Dien; Fisch, Margit; Sauter, Guido; Graefen, Markus; Huland, Hartwig; Chun, Felix K H; Ahyai, Sascha A.

In: WORLD J UROL, Vol. 35, No. 2, 02.2017, p. 199-206.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meyer, CP, Hansen, J, Boehm, K, Tilki, D, Abdollah, F, Trinh, Q-D, Fisch, M, Sauter, G, Graefen, M, Huland, H, Chun, FKH & Ahyai, SA 2017, 'Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins', WORLD J UROL, vol. 35, no. 2, pp. 199-206. https://doi.org/10.1007/s00345-016-1861-z

APA

Meyer, C. P., Hansen, J., Boehm, K., Tilki, D., Abdollah, F., Trinh, Q-D., Fisch, M., Sauter, G., Graefen, M., Huland, H., Chun, F. K. H., & Ahyai, S. A. (2017). Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins. WORLD J UROL, 35(2), 199-206. https://doi.org/10.1007/s00345-016-1861-z

Vancouver

Meyer CP, Hansen J, Boehm K, Tilki D, Abdollah F, Trinh Q-D et al. Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins. WORLD J UROL. 2017 Feb;35(2):199-206. https://doi.org/10.1007/s00345-016-1861-z

Bibtex

@article{f1539999b1224ce3bdd4ebc828c25456,
title = "Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins",
abstract = "PURPOSE: To develop a novel application evaluating the effect of tumor volume (TV) and percentage of high-grade tumor volume (%HGTV) on long-term biochemical recurrence-free survival rate (BCRFS) after radical prostatectomy (RP) in patients with pT2 PCa.METHODS: Retrospective analysis of 903 men with pT2 PCa between 1992 and 2004 at a single European tertiary care center was performed. Cox regression models identified risk factors for BCR. A nomogram was developed to predict the BCRFS at 5, 10 and 15 years after RP. Decision curve analyses were performed to identify the net increase in cases identified by the full model.RESULTS: BCR-free survival rates at 5, 10 and 15 years were 94, 90 and 86 %. In Cox regression analyses, TV, %HGTV and positive surgical margin status (SM) were independent predictors of BCR. Predictive accuracies (PA) at 5, 10 and 15 years of the base model (PSA, Gleason score, SM) were 76.8 % (95 % CI 67.9-78.2 %), 70.5 % (95 % CI 64.9-75.0 %) and 68.1 % (95 % CI 60.6-73.5 %). The full model, including TV and %HGTV, achieved 76.9, 72.4 and 70.7 %. These PA differences were statistically significant at 10 and 15 years (p < 0.001).CONCLUSIONS: TV and %HGTV could potentially serve as valuable measures to stratify patients at high risk of BCR. The use of our nomogram should be considered to counsel patients with pT2 disease and SM and to design appropriate follow-up or treatment regimens.",
author = "Meyer, {Christian P} and Jens Hansen and Katharina Boehm and Derya Tilki and Firas Abdollah and Quoc-Dien Trinh and Margit Fisch and Guido Sauter and Markus Graefen and Hartwig Huland and Chun, {Felix K H} and Ahyai, {Sascha A}",
year = "2017",
month = feb,
doi = "10.1007/s00345-016-1861-z",
language = "English",
volume = "35",
pages = "199--206",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Tumor volume improves the long-term prediction of biochemical recurrence-free survival after radical prostatectomy for localized prostate cancer with positive surgical margins

AU - Meyer, Christian P

AU - Hansen, Jens

AU - Boehm, Katharina

AU - Tilki, Derya

AU - Abdollah, Firas

AU - Trinh, Quoc-Dien

AU - Fisch, Margit

AU - Sauter, Guido

AU - Graefen, Markus

AU - Huland, Hartwig

AU - Chun, Felix K H

AU - Ahyai, Sascha A

PY - 2017/2

Y1 - 2017/2

N2 - PURPOSE: To develop a novel application evaluating the effect of tumor volume (TV) and percentage of high-grade tumor volume (%HGTV) on long-term biochemical recurrence-free survival rate (BCRFS) after radical prostatectomy (RP) in patients with pT2 PCa.METHODS: Retrospective analysis of 903 men with pT2 PCa between 1992 and 2004 at a single European tertiary care center was performed. Cox regression models identified risk factors for BCR. A nomogram was developed to predict the BCRFS at 5, 10 and 15 years after RP. Decision curve analyses were performed to identify the net increase in cases identified by the full model.RESULTS: BCR-free survival rates at 5, 10 and 15 years were 94, 90 and 86 %. In Cox regression analyses, TV, %HGTV and positive surgical margin status (SM) were independent predictors of BCR. Predictive accuracies (PA) at 5, 10 and 15 years of the base model (PSA, Gleason score, SM) were 76.8 % (95 % CI 67.9-78.2 %), 70.5 % (95 % CI 64.9-75.0 %) and 68.1 % (95 % CI 60.6-73.5 %). The full model, including TV and %HGTV, achieved 76.9, 72.4 and 70.7 %. These PA differences were statistically significant at 10 and 15 years (p < 0.001).CONCLUSIONS: TV and %HGTV could potentially serve as valuable measures to stratify patients at high risk of BCR. The use of our nomogram should be considered to counsel patients with pT2 disease and SM and to design appropriate follow-up or treatment regimens.

AB - PURPOSE: To develop a novel application evaluating the effect of tumor volume (TV) and percentage of high-grade tumor volume (%HGTV) on long-term biochemical recurrence-free survival rate (BCRFS) after radical prostatectomy (RP) in patients with pT2 PCa.METHODS: Retrospective analysis of 903 men with pT2 PCa between 1992 and 2004 at a single European tertiary care center was performed. Cox regression models identified risk factors for BCR. A nomogram was developed to predict the BCRFS at 5, 10 and 15 years after RP. Decision curve analyses were performed to identify the net increase in cases identified by the full model.RESULTS: BCR-free survival rates at 5, 10 and 15 years were 94, 90 and 86 %. In Cox regression analyses, TV, %HGTV and positive surgical margin status (SM) were independent predictors of BCR. Predictive accuracies (PA) at 5, 10 and 15 years of the base model (PSA, Gleason score, SM) were 76.8 % (95 % CI 67.9-78.2 %), 70.5 % (95 % CI 64.9-75.0 %) and 68.1 % (95 % CI 60.6-73.5 %). The full model, including TV and %HGTV, achieved 76.9, 72.4 and 70.7 %. These PA differences were statistically significant at 10 and 15 years (p < 0.001).CONCLUSIONS: TV and %HGTV could potentially serve as valuable measures to stratify patients at high risk of BCR. The use of our nomogram should be considered to counsel patients with pT2 disease and SM and to design appropriate follow-up or treatment regimens.

U2 - 10.1007/s00345-016-1861-z

DO - 10.1007/s00345-016-1861-z

M3 - SCORING: Journal article

C2 - 27260503

VL - 35

SP - 199

EP - 206

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 2

ER -