Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.

Carsten Janke; Matthias Kneussel

doi:10.1016/j.tins.2010.05.001

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.

Standard

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. / Janke, Carsten; Kneussel, Matthias.

In: TRENDS NEUROSCI, Vol. 33, No. 8, 8, 01.08.2010, p. 362-372.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Janke, C & Kneussel, M 2010, 'Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.', TRENDS NEUROSCI, vol. 33, no. 8, 8, pp. 362-372. https://doi.org/10.1016/j.tins.2010.05.001

APA

Janke, C., & Kneussel, M. (2010). Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. TRENDS NEUROSCI, 33(8), 362-372. [8]. https://doi.org/10.1016/j.tins.2010.05.001

Vancouver

Janke C, Kneussel M. Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. TRENDS NEUROSCI. 2010 Aug 1;33(8):362-372. 8. https://doi.org/10.1016/j.tins.2010.05.001

Bibtex

@article{cb57d77d589040b380f56816e5a0cbd5,

title = "Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.",

abstract = "In the past decades, a range of post-translational modifications has been discovered on tubulins, the major constituents of microtubules. Pioneering studies have described the occurrence and dynamics of these modifications and provided first insights into their potential functions in regulating the microtubule cytoskeleton. By contrast, several tubulin-modifying enzymes were only discovered in the last few years, and studies on molecular mechanisms and cellular functions of tubulin modifications are just beginning to emerge. This review highlights the roles of tubulin modifications in neurons. Recent studies are also discussed in relation to how the combinatorial use of tubulin modifications could generate a dynamic microtubule code, and how such a code might regulate basic as well as higher-order neuronal functions.",

keywords = "Animals, Cytoskeleton, Microtubules, Neurons, Protein Processing, Post-Translational, Tubulin",

author = "Carsten Janke and Matthias Kneussel",

year = "2010",

month = aug,

day = "1",

doi = "10.1016/j.tins.2010.05.001",

language = "English",

volume = "33",

pages = "362--372",

journal = "TRENDS NEUROSCI",

issn = "0166-2236",

publisher = "Elsevier Limited",

number = "8",

}

RIS

TY - JOUR

T1 - Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.

AU - Janke, Carsten

AU - Kneussel, Matthias

PY - 2010/8/1

Y1 - 2010/8/1

N2 - In the past decades, a range of post-translational modifications has been discovered on tubulins, the major constituents of microtubules. Pioneering studies have described the occurrence and dynamics of these modifications and provided first insights into their potential functions in regulating the microtubule cytoskeleton. By contrast, several tubulin-modifying enzymes were only discovered in the last few years, and studies on molecular mechanisms and cellular functions of tubulin modifications are just beginning to emerge. This review highlights the roles of tubulin modifications in neurons. Recent studies are also discussed in relation to how the combinatorial use of tubulin modifications could generate a dynamic microtubule code, and how such a code might regulate basic as well as higher-order neuronal functions.

AB - In the past decades, a range of post-translational modifications has been discovered on tubulins, the major constituents of microtubules. Pioneering studies have described the occurrence and dynamics of these modifications and provided first insights into their potential functions in regulating the microtubule cytoskeleton. By contrast, several tubulin-modifying enzymes were only discovered in the last few years, and studies on molecular mechanisms and cellular functions of tubulin modifications are just beginning to emerge. This review highlights the roles of tubulin modifications in neurons. Recent studies are also discussed in relation to how the combinatorial use of tubulin modifications could generate a dynamic microtubule code, and how such a code might regulate basic as well as higher-order neuronal functions.

KW - Animals

KW - Cytoskeleton

KW - Microtubules

KW - Neurons

KW - Protein Processing, Post-Translational

KW - Tubulin

U2 - 10.1016/j.tins.2010.05.001

DO - 10.1016/j.tins.2010.05.001

M3 - SCORING: Journal article

C2 - 20541813

VL - 33

SP - 362

EP - 372

JO - TRENDS NEUROSCI

JF - TRENDS NEUROSCI

SN - 0166-2236

IS - 8

M1 - 8

ER -