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Trp53 Deficiency Protects against Acute Intestinal Inflammation.

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Trp53 Deficiency Protects against Acute Intestinal Inflammation. / Spehlmann, Martina E; Manthey, Carolin; Dann, Sara M; Hanson, Elaine; Sandhu, Sukhman S; Liu, Linus Y; Abdelmalak, Farid K; Diamanti, Michaela A; Retzlaff, Kristin; Scheller, Jürgen; Rose-John, Stefan; Greten, Florian R; Wang, Jean Y J; Eckmann, Lars.

In: J IMMUNOL, Vol. 191, No. 2, 2, 2013, p. 837-847.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Spehlmann, ME, Manthey, C, Dann, SM, Hanson, E, Sandhu, SS, Liu, LY, Abdelmalak, FK, Diamanti, MA, Retzlaff, K, Scheller, J, Rose-John, S, Greten, FR, Wang, JYJ & Eckmann, L 2013, 'Trp53 Deficiency Protects against Acute Intestinal Inflammation.', J IMMUNOL, vol. 191, no. 2, 2, pp. 837-847. <http://www.ncbi.nlm.nih.gov/pubmed/23772033?dopt=Citation>

APA

Spehlmann, M. E., Manthey, C., Dann, S. M., Hanson, E., Sandhu, S. S., Liu, L. Y., Abdelmalak, F. K., Diamanti, M. A., Retzlaff, K., Scheller, J., Rose-John, S., Greten, F. R., Wang, J. Y. J., & Eckmann, L. (2013). Trp53 Deficiency Protects against Acute Intestinal Inflammation. J IMMUNOL, 191(2), 837-847. [2]. http://www.ncbi.nlm.nih.gov/pubmed/23772033?dopt=Citation

Vancouver

Spehlmann ME, Manthey C, Dann SM, Hanson E, Sandhu SS, Liu LY et al. Trp53 Deficiency Protects against Acute Intestinal Inflammation. J IMMUNOL. 2013;191(2):837-847. 2.

Bibtex

@article{87c41b520a0b493cab43bf3d7262ff7e,
title = "Trp53 Deficiency Protects against Acute Intestinal Inflammation.",
abstract = "The p53 protein has not only important tumor suppressor activity but also additional immunological and other functions, whose nature and extent are just beginning to be recognized. In this article, we show that p53 has a novel inflammation-promoting action in the intestinal tract, because loss of p53 or the upstream activating kinase, ATM, protects against acute intestinal inflammation in murine models. Mechanistically, deficiency in p53 leads to increased survival of epithelial cells and lamina propria macrophages, higher IL-6 expression owing to enhanced glucose-dependent NF-?B activation, and increased mucosal STAT3 activation. Blockade or loss of IL-6 signaling reverses the protective effects of p53 deficiency. Conversely, IL-6 treatment protects against acute colitis in a manner dependent on STAT3 signaling and induction of cytoprotective factors in epithelial cells. Together, these results indicate that p53 promotes inflammation in the intestinal tract through suppression of epithelium-protective factors, thus significantly expanding the spectrum of physiological and immunological p53 activities unrelated to cancer formation.",
author = "Spehlmann, {Martina E} and Carolin Manthey and Dann, {Sara M} and Elaine Hanson and Sandhu, {Sukhman S} and Liu, {Linus Y} and Abdelmalak, {Farid K} and Diamanti, {Michaela A} and Kristin Retzlaff and J{\"u}rgen Scheller and Stefan Rose-John and Greten, {Florian R} and Wang, {Jean Y J} and Lars Eckmann",
year = "2013",
language = "English",
volume = "191",
pages = "837--847",
journal = "J IMMUNOL",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "2",

}

RIS

TY - JOUR

T1 - Trp53 Deficiency Protects against Acute Intestinal Inflammation.

AU - Spehlmann, Martina E

AU - Manthey, Carolin

AU - Dann, Sara M

AU - Hanson, Elaine

AU - Sandhu, Sukhman S

AU - Liu, Linus Y

AU - Abdelmalak, Farid K

AU - Diamanti, Michaela A

AU - Retzlaff, Kristin

AU - Scheller, Jürgen

AU - Rose-John, Stefan

AU - Greten, Florian R

AU - Wang, Jean Y J

AU - Eckmann, Lars

PY - 2013

Y1 - 2013

N2 - The p53 protein has not only important tumor suppressor activity but also additional immunological and other functions, whose nature and extent are just beginning to be recognized. In this article, we show that p53 has a novel inflammation-promoting action in the intestinal tract, because loss of p53 or the upstream activating kinase, ATM, protects against acute intestinal inflammation in murine models. Mechanistically, deficiency in p53 leads to increased survival of epithelial cells and lamina propria macrophages, higher IL-6 expression owing to enhanced glucose-dependent NF-?B activation, and increased mucosal STAT3 activation. Blockade or loss of IL-6 signaling reverses the protective effects of p53 deficiency. Conversely, IL-6 treatment protects against acute colitis in a manner dependent on STAT3 signaling and induction of cytoprotective factors in epithelial cells. Together, these results indicate that p53 promotes inflammation in the intestinal tract through suppression of epithelium-protective factors, thus significantly expanding the spectrum of physiological and immunological p53 activities unrelated to cancer formation.

AB - The p53 protein has not only important tumor suppressor activity but also additional immunological and other functions, whose nature and extent are just beginning to be recognized. In this article, we show that p53 has a novel inflammation-promoting action in the intestinal tract, because loss of p53 or the upstream activating kinase, ATM, protects against acute intestinal inflammation in murine models. Mechanistically, deficiency in p53 leads to increased survival of epithelial cells and lamina propria macrophages, higher IL-6 expression owing to enhanced glucose-dependent NF-?B activation, and increased mucosal STAT3 activation. Blockade or loss of IL-6 signaling reverses the protective effects of p53 deficiency. Conversely, IL-6 treatment protects against acute colitis in a manner dependent on STAT3 signaling and induction of cytoprotective factors in epithelial cells. Together, these results indicate that p53 promotes inflammation in the intestinal tract through suppression of epithelium-protective factors, thus significantly expanding the spectrum of physiological and immunological p53 activities unrelated to cancer formation.

M3 - SCORING: Journal article

VL - 191

SP - 837

EP - 847

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 2

M1 - 2

ER -