Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy

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Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy. / Quidde, Julia; Alsdorf, Winfried H; von Amsberg, Gunhild; Wilczak, Waldemar; Bokemeyer, Carsten.

In: ONCOL RES TREAT, Vol. 41, No. 1-2, 2018, p. 58-60.

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@article{5c3ebff35ac64c288c79b86d23d6ef76,
title = "Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy",
abstract = "BACKGROUND: Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a very rare tumor that occurs mainly in pediatric patients and young adults. Only few of these patients develops metastatic disease; therefore, clinical data regarding treatment and outcome of metastatic SETTLE are extremely limited. Several chemotherapy agents have been used in SETTLE but due to the limited number of patients no evidence-based therapy exists.CASE REPORT: We present a case of metastatic SETTLE presenting with high tumor burden and paraneoplastic hypercalcemia. Prolonged disease control with several lines of platinum-based chemotherapy, anti-epidermal growth factor receptor therapy and additional radiotherapy was achieved.CONCLUSION: Multi-agent chemotherapy is an active treatment in metastatic SETTLE and can induce sustained tumor control.",
keywords = "Journal Article",
author = "Julia Quidde and Alsdorf, {Winfried H} and {von Amsberg}, Gunhild and Waldemar Wilczak and Carsten Bokemeyer",
note = "{\textcopyright} 2018 S. Karger GmbH, Freiburg.",
year = "2018",
doi = "10.1159/000480017",
language = "English",
volume = "41",
pages = "58--60",
journal = "ONCOL RES TREAT",
issn = "2296-5270",
publisher = "S. Karger AG",
number = "1-2",

}

RIS

TY - JOUR

T1 - Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy

AU - Quidde, Julia

AU - Alsdorf, Winfried H

AU - von Amsberg, Gunhild

AU - Wilczak, Waldemar

AU - Bokemeyer, Carsten

N1 - © 2018 S. Karger GmbH, Freiburg.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a very rare tumor that occurs mainly in pediatric patients and young adults. Only few of these patients develops metastatic disease; therefore, clinical data regarding treatment and outcome of metastatic SETTLE are extremely limited. Several chemotherapy agents have been used in SETTLE but due to the limited number of patients no evidence-based therapy exists.CASE REPORT: We present a case of metastatic SETTLE presenting with high tumor burden and paraneoplastic hypercalcemia. Prolonged disease control with several lines of platinum-based chemotherapy, anti-epidermal growth factor receptor therapy and additional radiotherapy was achieved.CONCLUSION: Multi-agent chemotherapy is an active treatment in metastatic SETTLE and can induce sustained tumor control.

AB - BACKGROUND: Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a very rare tumor that occurs mainly in pediatric patients and young adults. Only few of these patients develops metastatic disease; therefore, clinical data regarding treatment and outcome of metastatic SETTLE are extremely limited. Several chemotherapy agents have been used in SETTLE but due to the limited number of patients no evidence-based therapy exists.CASE REPORT: We present a case of metastatic SETTLE presenting with high tumor burden and paraneoplastic hypercalcemia. Prolonged disease control with several lines of platinum-based chemotherapy, anti-epidermal growth factor receptor therapy and additional radiotherapy was achieved.CONCLUSION: Multi-agent chemotherapy is an active treatment in metastatic SETTLE and can induce sustained tumor control.

KW - Journal Article

U2 - 10.1159/000480017

DO - 10.1159/000480017

M3 - SCORING: Journal article

C2 - 29402817

VL - 41

SP - 58

EP - 60

JO - ONCOL RES TREAT

JF - ONCOL RES TREAT

SN - 2296-5270

IS - 1-2

ER -