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Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients

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Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients. / Teltschik, Heiko-Manuel; Heinzelmann, Frank; Gruhn, Bernd; Feuchtinger, Tobias; Schlegel, Patrick; Schumm, Michael; Kremens, Bernhard; Müller, Ingo; Ebinger, Martin; Schwarze, Carl Philipp; Ottinger, Hellmut; Zips, Daniel; Handgretinger, Rupert; Lang, Peter.

In: BRIT J HAEMATOL, Vol. 175, No. 1, 24.06.2016, p. 115-22.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Teltschik, H-M, Heinzelmann, F, Gruhn, B, Feuchtinger, T, Schlegel, P, Schumm, M, Kremens, B, Müller, I, Ebinger, M, Schwarze, CP, Ottinger, H, Zips, D, Handgretinger, R & Lang, P 2016, 'Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients', BRIT J HAEMATOL, vol. 175, no. 1, pp. 115-22. https://doi.org/10.1111/bjh.14190

APA

Teltschik, H-M., Heinzelmann, F., Gruhn, B., Feuchtinger, T., Schlegel, P., Schumm, M., Kremens, B., Müller, I., Ebinger, M., Schwarze, C. P., Ottinger, H., Zips, D., Handgretinger, R., & Lang, P. (2016). Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients. BRIT J HAEMATOL, 175(1), 115-22. https://doi.org/10.1111/bjh.14190

Vancouver

Teltschik H-M, Heinzelmann F, Gruhn B, Feuchtinger T, Schlegel P, Schumm M et al. Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients. BRIT J HAEMATOL. 2016 Jun 24;175(1):115-22. https://doi.org/10.1111/bjh.14190

Bibtex

@article{ab6abcb801c24db7b42c8f5c266d0eb2,
title = "Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients",
abstract = "Graft failure is a life-threatening complication after allogeneic haematopoietic stem cell transplantation (HSCT). We report a cohort of 19 consecutive patients (median age: 8·5 years) with acute leukaemias (n = 14) and non-malignant diseases (n = 5) who experienced graft failure after previous HSCT from matched (n = 3) or haploidentical donors (n = 16) between 2003 and 2012. After total nodal irradiation (TNI)-based reconditioning combined with fludarabine, thiotepa and anti-T cell serotherapy, all patients received T cell-depleted peripheral blood stem cell grafts from a second, haploidentical donor. Median time between graft failure and retransplantation was 14 d (range 7-40). Sustained engraftment (median: 10 d, range 9-32) and complete donor chimerism was observed in all evaluable patients. 5 patients additionally received donor lymphocyte infusions. Graft-versus-host disease (GvHD) grade II and III occurred in 1 patient each (22%); no GvHD grade IV was observed. 2 patients had transient chronic GvHD. The regimen was well tolerated with transient interstitial pneumonitis in one patient. Treatment-related mortality after one year was 11%. Event-free survival and overall survival 3 years after retransplantation were 63% and 68%. Thus, a TNI-based reconditioning regimen followed by transplantation of haploidentical stem cells is an option to rescue patients with graft failure within a short time span and with low toxicity.",
author = "Heiko-Manuel Teltschik and Frank Heinzelmann and Bernd Gruhn and Tobias Feuchtinger and Patrick Schlegel and Michael Schumm and Bernhard Kremens and Ingo M{\"u}ller and Martin Ebinger and Schwarze, {Carl Philipp} and Hellmut Ottinger and Daniel Zips and Rupert Handgretinger and Peter Lang",
note = "{\textcopyright} 2016 John Wiley & Sons Ltd.",
year = "2016",
month = jun,
day = "24",
doi = "10.1111/bjh.14190",
language = "English",
volume = "175",
pages = "115--22",
journal = "BRIT J HAEMATOL",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients

AU - Teltschik, Heiko-Manuel

AU - Heinzelmann, Frank

AU - Gruhn, Bernd

AU - Feuchtinger, Tobias

AU - Schlegel, Patrick

AU - Schumm, Michael

AU - Kremens, Bernhard

AU - Müller, Ingo

AU - Ebinger, Martin

AU - Schwarze, Carl Philipp

AU - Ottinger, Hellmut

AU - Zips, Daniel

AU - Handgretinger, Rupert

AU - Lang, Peter

N1 - © 2016 John Wiley & Sons Ltd.

PY - 2016/6/24

Y1 - 2016/6/24

N2 - Graft failure is a life-threatening complication after allogeneic haematopoietic stem cell transplantation (HSCT). We report a cohort of 19 consecutive patients (median age: 8·5 years) with acute leukaemias (n = 14) and non-malignant diseases (n = 5) who experienced graft failure after previous HSCT from matched (n = 3) or haploidentical donors (n = 16) between 2003 and 2012. After total nodal irradiation (TNI)-based reconditioning combined with fludarabine, thiotepa and anti-T cell serotherapy, all patients received T cell-depleted peripheral blood stem cell grafts from a second, haploidentical donor. Median time between graft failure and retransplantation was 14 d (range 7-40). Sustained engraftment (median: 10 d, range 9-32) and complete donor chimerism was observed in all evaluable patients. 5 patients additionally received donor lymphocyte infusions. Graft-versus-host disease (GvHD) grade II and III occurred in 1 patient each (22%); no GvHD grade IV was observed. 2 patients had transient chronic GvHD. The regimen was well tolerated with transient interstitial pneumonitis in one patient. Treatment-related mortality after one year was 11%. Event-free survival and overall survival 3 years after retransplantation were 63% and 68%. Thus, a TNI-based reconditioning regimen followed by transplantation of haploidentical stem cells is an option to rescue patients with graft failure within a short time span and with low toxicity.

AB - Graft failure is a life-threatening complication after allogeneic haematopoietic stem cell transplantation (HSCT). We report a cohort of 19 consecutive patients (median age: 8·5 years) with acute leukaemias (n = 14) and non-malignant diseases (n = 5) who experienced graft failure after previous HSCT from matched (n = 3) or haploidentical donors (n = 16) between 2003 and 2012. After total nodal irradiation (TNI)-based reconditioning combined with fludarabine, thiotepa and anti-T cell serotherapy, all patients received T cell-depleted peripheral blood stem cell grafts from a second, haploidentical donor. Median time between graft failure and retransplantation was 14 d (range 7-40). Sustained engraftment (median: 10 d, range 9-32) and complete donor chimerism was observed in all evaluable patients. 5 patients additionally received donor lymphocyte infusions. Graft-versus-host disease (GvHD) grade II and III occurred in 1 patient each (22%); no GvHD grade IV was observed. 2 patients had transient chronic GvHD. The regimen was well tolerated with transient interstitial pneumonitis in one patient. Treatment-related mortality after one year was 11%. Event-free survival and overall survival 3 years after retransplantation were 63% and 68%. Thus, a TNI-based reconditioning regimen followed by transplantation of haploidentical stem cells is an option to rescue patients with graft failure within a short time span and with low toxicity.

U2 - 10.1111/bjh.14190

DO - 10.1111/bjh.14190

M3 - SCORING: Journal article

C2 - 27341180

VL - 175

SP - 115

EP - 122

JO - BRIT J HAEMATOL

JF - BRIT J HAEMATOL

SN - 0007-1048

IS - 1

ER -