Treatment of brain metastases from germ cell tumors.
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Treatment of brain metastases from germ cell tumors. / Oechsle, Karin; Bokemeyer, Carsten.
In: HEMATOL ONCOL CLIN N, Vol. 25, No. 3, 3, 2011, p. 605-613.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Treatment of brain metastases from germ cell tumors.
AU - Oechsle, Karin
AU - Bokemeyer, Carsten
PY - 2011
Y1 - 2011
N2 - Brain metastases occur in approximately 10% of patients with advanced metastatic germ cell tumors. Patients with nonseminomatous histology, lung metastases, and high ?-human chorionic gonadotropin levels are at higher risk for synchronous brain metastases at first diagnosis and for relapsing with brain metastases after successful cisplatin-based chemotherapy. Patients with brain metastases should undergo multimodal treatment strategies, including cisplatin-based combination chemotherapy plus radiotherapy or surgery. However, the optimal combination and sequence of these strategies remain unclear and may differ between subgroups. But in all cases, chemotherapy must be part of treatment, even in patients with isolated cerebral relapse without systemic disease.
AB - Brain metastases occur in approximately 10% of patients with advanced metastatic germ cell tumors. Patients with nonseminomatous histology, lung metastases, and high ?-human chorionic gonadotropin levels are at higher risk for synchronous brain metastases at first diagnosis and for relapsing with brain metastases after successful cisplatin-based chemotherapy. Patients with brain metastases should undergo multimodal treatment strategies, including cisplatin-based combination chemotherapy plus radiotherapy or surgery. However, the optimal combination and sequence of these strategies remain unclear and may differ between subgroups. But in all cases, chemotherapy must be part of treatment, even in patients with isolated cerebral relapse without systemic disease.
KW - Humans
KW - Male
KW - Combined Modality Therapy
KW - Neurosurgical Procedures
KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
KW - Radiotherapy
KW - Brain/drug effects/radiation effects/surgery
KW - Brain Neoplasms/drug therapy/secondary/therapy
KW - Neoplasms, Germ Cell and Embryonal/drug therapy/secondary/therapy
KW - Testicular Neoplasms/drug therapy/pathology/therapy
KW - Humans
KW - Male
KW - Combined Modality Therapy
KW - Neurosurgical Procedures
KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
KW - Radiotherapy
KW - Brain/drug effects/radiation effects/surgery
KW - Brain Neoplasms/drug therapy/secondary/therapy
KW - Neoplasms, Germ Cell and Embryonal/drug therapy/secondary/therapy
KW - Testicular Neoplasms/drug therapy/pathology/therapy
M3 - SCORING: Journal article
VL - 25
SP - 605
EP - 613
IS - 3
M1 - 3
ER -
