Translational Aspects of Primary Membranous Nephropathy

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Translational Aspects of Primary Membranous Nephropathy. / Hoxha, Elion; Stahl, Rolf A K.

In: SEMIN NEPHROL, Vol. 37, No. 5, 09.2017, p. 436-446.

Research output: SCORING: Contribution to journalSCORING: Review articleResearch

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@article{75bdb06cede0472f9f6951b513a35785,
title = "Translational Aspects of Primary Membranous Nephropathy",
abstract = "Membranous nephropathy (MN) in an autoimmune disease caused by binding of circulating antibodies to podocytic antigens. The search for the responsible target antigens has extended for more than 50 years and led to the identification of the major pathomechanisms leading to MN. The combination of clinical and morphologic observations, experimental work, and technical advancements has enabled us deep insights in the pathophysiology of this disease, simultaneously improving treatment of patients. MN represents a perfect example of how patient care may profit from the convergence of scientific and clinical achievements and the benefits of translational approaches in medicine.",
keywords = "Animals, Autoantibodies/blood, Disease Models, Animal, Glomerulonephritis, Membranous/diagnosis, Humans, Receptors, Phospholipase A2/analysis, Thrombospondins/analysis, Translational Medical Research",
author = "Elion Hoxha and Stahl, {Rolf A K}",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = sep,
doi = "10.1016/j.semnephrol.2017.05.017",
language = "English",
volume = "37",
pages = "436--446",
journal = "SEMIN NEPHROL",
issn = "0270-9295",
publisher = "W B SAUNDERS CO-ELSEVIER INC",
number = "5",

}

RIS

TY - JOUR

T1 - Translational Aspects of Primary Membranous Nephropathy

AU - Hoxha, Elion

AU - Stahl, Rolf A K

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/9

Y1 - 2017/9

N2 - Membranous nephropathy (MN) in an autoimmune disease caused by binding of circulating antibodies to podocytic antigens. The search for the responsible target antigens has extended for more than 50 years and led to the identification of the major pathomechanisms leading to MN. The combination of clinical and morphologic observations, experimental work, and technical advancements has enabled us deep insights in the pathophysiology of this disease, simultaneously improving treatment of patients. MN represents a perfect example of how patient care may profit from the convergence of scientific and clinical achievements and the benefits of translational approaches in medicine.

AB - Membranous nephropathy (MN) in an autoimmune disease caused by binding of circulating antibodies to podocytic antigens. The search for the responsible target antigens has extended for more than 50 years and led to the identification of the major pathomechanisms leading to MN. The combination of clinical and morphologic observations, experimental work, and technical advancements has enabled us deep insights in the pathophysiology of this disease, simultaneously improving treatment of patients. MN represents a perfect example of how patient care may profit from the convergence of scientific and clinical achievements and the benefits of translational approaches in medicine.

KW - Animals

KW - Autoantibodies/blood

KW - Disease Models, Animal

KW - Glomerulonephritis, Membranous/diagnosis

KW - Humans

KW - Receptors, Phospholipase A2/analysis

KW - Thrombospondins/analysis

KW - Translational Medical Research

U2 - 10.1016/j.semnephrol.2017.05.017

DO - 10.1016/j.semnephrol.2017.05.017

M3 - SCORING: Review article

C2 - 28863791

VL - 37

SP - 436

EP - 446

JO - SEMIN NEPHROL

JF - SEMIN NEPHROL

SN - 0270-9295

IS - 5

ER -