Translational Aspects of Primary Membranous Nephropathy
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Translational Aspects of Primary Membranous Nephropathy. / Hoxha, Elion; Stahl, Rolf A K.
In: SEMIN NEPHROL, Vol. 37, No. 5, 09.2017, p. 436-446.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Translational Aspects of Primary Membranous Nephropathy
AU - Hoxha, Elion
AU - Stahl, Rolf A K
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/9
Y1 - 2017/9
N2 - Membranous nephropathy (MN) in an autoimmune disease caused by binding of circulating antibodies to podocytic antigens. The search for the responsible target antigens has extended for more than 50 years and led to the identification of the major pathomechanisms leading to MN. The combination of clinical and morphologic observations, experimental work, and technical advancements has enabled us deep insights in the pathophysiology of this disease, simultaneously improving treatment of patients. MN represents a perfect example of how patient care may profit from the convergence of scientific and clinical achievements and the benefits of translational approaches in medicine.
AB - Membranous nephropathy (MN) in an autoimmune disease caused by binding of circulating antibodies to podocytic antigens. The search for the responsible target antigens has extended for more than 50 years and led to the identification of the major pathomechanisms leading to MN. The combination of clinical and morphologic observations, experimental work, and technical advancements has enabled us deep insights in the pathophysiology of this disease, simultaneously improving treatment of patients. MN represents a perfect example of how patient care may profit from the convergence of scientific and clinical achievements and the benefits of translational approaches in medicine.
KW - Animals
KW - Autoantibodies/blood
KW - Disease Models, Animal
KW - Glomerulonephritis, Membranous/diagnosis
KW - Humans
KW - Receptors, Phospholipase A2/analysis
KW - Thrombospondins/analysis
KW - Translational Medical Research
U2 - 10.1016/j.semnephrol.2017.05.017
DO - 10.1016/j.semnephrol.2017.05.017
M3 - SCORING: Review article
C2 - 28863791
VL - 37
SP - 436
EP - 446
JO - SEMIN NEPHROL
JF - SEMIN NEPHROL
SN - 0270-9295
IS - 5
ER -