Transitions between asynchronous and synchronous states

TY - JOUR

T1 - Transitions between asynchronous and synchronous states

T2 - a theory of correlations in small neural circuits

AU - Fasoli, Diego

AU - Cattani, Anna

AU - Panzeri, Stefano

PY - 2018/2

Y1 - 2018/2

N2 - The study of correlations in neural circuits of different size, from the small size of cortical microcolumns to the large-scale organization of distributed networks studied with functional imaging, is a topic of central importance to systems neuroscience. However, a theory that explains how the parameters of mesoscopic networks composed of a few tens of neurons affect the underlying correlation structure is still missing. Here we consider a theory that can be applied to networks of arbitrary size with multiple populations of homogeneous fully-connected neurons, and we focus its analysis to a case of two populations of small size. We combine the analysis of local bifurcations of the dynamics of these networks with the analytical calculation of their cross-correlations. We study the correlation structure in different regimes, showing that a variation of the external stimuli causes the network to switch from asynchronous states, characterized by weak correlation and low variability, to synchronous states characterized by strong correlations and wide temporal fluctuations. We show that asynchronous states are generated by strong stimuli, while synchronous states occur through critical slowing down when the stimulus moves the network close to a local bifurcation. In particular, strongly positive correlations occur at the saddle-node and Andronov-Hopf bifurcations of the network, while strongly negative correlations occur when the network undergoes a spontaneous symmetry-breaking at the branching-point bifurcations. These results show how the correlation structure of firing-rate network models is strongly modulated by the external stimuli, even keeping the anatomical connections fixed. These results also suggest an effective mechanism through which biological networks may dynamically modulate the encoding and integration of sensory information.

AB - The study of correlations in neural circuits of different size, from the small size of cortical microcolumns to the large-scale organization of distributed networks studied with functional imaging, is a topic of central importance to systems neuroscience. However, a theory that explains how the parameters of mesoscopic networks composed of a few tens of neurons affect the underlying correlation structure is still missing. Here we consider a theory that can be applied to networks of arbitrary size with multiple populations of homogeneous fully-connected neurons, and we focus its analysis to a case of two populations of small size. We combine the analysis of local bifurcations of the dynamics of these networks with the analytical calculation of their cross-correlations. We study the correlation structure in different regimes, showing that a variation of the external stimuli causes the network to switch from asynchronous states, characterized by weak correlation and low variability, to synchronous states characterized by strong correlations and wide temporal fluctuations. We show that asynchronous states are generated by strong stimuli, while synchronous states occur through critical slowing down when the stimulus moves the network close to a local bifurcation. In particular, strongly positive correlations occur at the saddle-node and Andronov-Hopf bifurcations of the network, while strongly negative correlations occur when the network undergoes a spontaneous symmetry-breaking at the branching-point bifurcations. These results show how the correlation structure of firing-rate network models is strongly modulated by the external stimuli, even keeping the anatomical connections fixed. These results also suggest an effective mechanism through which biological networks may dynamically modulate the encoding and integration of sensory information.

KW - Action Potentials/physiology

KW - Correlation of Data

KW - Humans

KW - Models, Neurological

KW - Nerve Net/physiology

KW - Neural Networks, Computer

KW - Neurons/physiology

KW - Stochastic Processes

KW - Synapses/physiology

KW - Time Factors

U2 - 10.1007/s10827-017-0667-3

DO - 10.1007/s10827-017-0667-3

M3 - SCORING: Journal article

C2 - 29124505

VL - 44

SP - 25

EP - 43

JO - J COMPUT NEUROSCI

JF - J COMPUT NEUROSCI

SN - 0929-5313

IS - 1

ER -