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Transient lesion in the splenium related to antiepileptic drug

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Transient lesion in the splenium related to antiepileptic drug : case report and new pathophysiological insights. / Anneken, Kerstin; Evers, Stefan; Mohammadi, Siawoosh; Schwindt, Wolfram; Deppe, Michael.

In: SEIZURE-EUR J EPILEP, Vol. 17, No. 7, 01.10.2008, p. 654-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Anneken, K, Evers, S, Mohammadi, S, Schwindt, W & Deppe, M 2008, 'Transient lesion in the splenium related to antiepileptic drug: case report and new pathophysiological insights', SEIZURE-EUR J EPILEP, vol. 17, no. 7, pp. 654-7. https://doi.org/10.1016/j.seizure.2008.01.004

APA

Anneken, K., Evers, S., Mohammadi, S., Schwindt, W., & Deppe, M. (2008). Transient lesion in the splenium related to antiepileptic drug: case report and new pathophysiological insights. SEIZURE-EUR J EPILEP, 17(7), 654-7. https://doi.org/10.1016/j.seizure.2008.01.004

Vancouver

Anneken K, Evers S, Mohammadi S, Schwindt W, Deppe M. Transient lesion in the splenium related to antiepileptic drug: case report and new pathophysiological insights. SEIZURE-EUR J EPILEP. 2008 Oct 1;17(7):654-7. https://doi.org/10.1016/j.seizure.2008.01.004

Bibtex

@article{46197e5d326a44eabccce1cdc1f8636d,
title = "Transient lesion in the splenium related to antiepileptic drug: case report and new pathophysiological insights",
abstract = "Transient focal lesions in the splenium of the corpus callosum (SCC) have been associated with antiepileptic drug (AED) treatment. However, the aetiology is widely unknown. We describe a transient SCC lesion in an epilepsy patient after abrupt AED reduction. Whole head high-field diffusion tensor imaging (DTI) including fully automated quantitative fractional anisotropy (FA) analysis was used to get insight into the pathophysiology of transient SCC lesions. Our results demonstrate that a reversible loss of directional fibre organisation in the splenium, likely due to intramyelinic oedema, is the morphological correlate of transient SCC lesions. We conclude that DTI provides a highly sensitive and quantitative tool to detect subtle and transient loss of fibre integrity associated with AED treatment.",
keywords = "Anisotropy, Anticonvulsants, Brain Edema, Brain Injuries, Diffusion Magnetic Resonance Imaging, Epilepsy, Female, Humans, Middle Aged, Neurosecretory Systems",
author = "Kerstin Anneken and Stefan Evers and Siawoosh Mohammadi and Wolfram Schwindt and Michael Deppe",
year = "2008",
month = oct,
day = "1",
doi = "10.1016/j.seizure.2008.01.004",
language = "English",
volume = "17",
pages = "654--7",
journal = "SEIZURE-EUR J EPILEP",
issn = "1059-1311",
publisher = "W.B. Saunders Ltd",
number = "7",

}

RIS

TY - JOUR

T1 - Transient lesion in the splenium related to antiepileptic drug

T2 - case report and new pathophysiological insights

AU - Anneken, Kerstin

AU - Evers, Stefan

AU - Mohammadi, Siawoosh

AU - Schwindt, Wolfram

AU - Deppe, Michael

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Transient focal lesions in the splenium of the corpus callosum (SCC) have been associated with antiepileptic drug (AED) treatment. However, the aetiology is widely unknown. We describe a transient SCC lesion in an epilepsy patient after abrupt AED reduction. Whole head high-field diffusion tensor imaging (DTI) including fully automated quantitative fractional anisotropy (FA) analysis was used to get insight into the pathophysiology of transient SCC lesions. Our results demonstrate that a reversible loss of directional fibre organisation in the splenium, likely due to intramyelinic oedema, is the morphological correlate of transient SCC lesions. We conclude that DTI provides a highly sensitive and quantitative tool to detect subtle and transient loss of fibre integrity associated with AED treatment.

AB - Transient focal lesions in the splenium of the corpus callosum (SCC) have been associated with antiepileptic drug (AED) treatment. However, the aetiology is widely unknown. We describe a transient SCC lesion in an epilepsy patient after abrupt AED reduction. Whole head high-field diffusion tensor imaging (DTI) including fully automated quantitative fractional anisotropy (FA) analysis was used to get insight into the pathophysiology of transient SCC lesions. Our results demonstrate that a reversible loss of directional fibre organisation in the splenium, likely due to intramyelinic oedema, is the morphological correlate of transient SCC lesions. We conclude that DTI provides a highly sensitive and quantitative tool to detect subtle and transient loss of fibre integrity associated with AED treatment.

KW - Anisotropy

KW - Anticonvulsants

KW - Brain Edema

KW - Brain Injuries

KW - Diffusion Magnetic Resonance Imaging

KW - Epilepsy

KW - Female

KW - Humans

KW - Middle Aged

KW - Neurosecretory Systems

U2 - 10.1016/j.seizure.2008.01.004

DO - 10.1016/j.seizure.2008.01.004

M3 - SCORING: Journal article

C2 - 18329297

VL - 17

SP - 654

EP - 657

JO - SEIZURE-EUR J EPILEP

JF - SEIZURE-EUR J EPILEP

SN - 1059-1311

IS - 7

ER -