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Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes

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Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes. / Tigges, Eike; Kalbacher, Daniel; Thomas, Christina; Appelbaum, Sebastian; Deuschl, Florian; Schofer, Niklas; Schlüter, Michael; Conradi, Lenard; Schirmer, Johannes; Treede, Hendrik; Reichenspurner, Hermann; Blankenberg, Stefan; Schäfer, Ulrich; Lubos, Edith.

In: BIOMED RES INT , Vol. 2016, 2016, p. 3934842.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tigges, E, Kalbacher, D, Thomas, C, Appelbaum, S, Deuschl, F, Schofer, N, Schlüter, M, Conradi, L, Schirmer, J, Treede, H, Reichenspurner, H, Blankenberg, S, Schäfer, U & Lubos, E 2016, 'Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes', BIOMED RES INT , vol. 2016, pp. 3934842. https://doi.org/10.1155/2016/3934842

APA

Tigges, E., Kalbacher, D., Thomas, C., Appelbaum, S., Deuschl, F., Schofer, N., Schlüter, M., Conradi, L., Schirmer, J., Treede, H., Reichenspurner, H., Blankenberg, S., Schäfer, U., & Lubos, E. (2016). Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes. BIOMED RES INT , 2016, 3934842. https://doi.org/10.1155/2016/3934842

Vancouver

Tigges E, Kalbacher D, Thomas C, Appelbaum S, Deuschl F, Schofer N et al. Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes. BIOMED RES INT . 2016;2016:3934842. https://doi.org/10.1155/2016/3934842

Bibtex

@article{294f7b9da355483ca023506378712fb6,
title = "Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes",
abstract = "BACKGROUND: Analyses emphasizing gender-related differences in acute and long-term outcomes following MitraClip therapy for significant mitral regurgitation (MR) are rare.METHODS: 592 consecutive patients (75 ± 8.7 years, 362 men, 230 women) underwent clinical and echocardiographic follow-up for a median of 2.13 (0.99-4.02) years.RESULTS: Significantly higher prevalence of cardiovascular comorbidities, renal failure, and adverse echocardiographic parameters in men resulted in longer device time (p = 0.007) and higher numbers of implanted clips (p = 0.0075), with equal procedural success (p = 1.0). Rehospitalization for heart failure did not differ (p[logrank] = 0.288) while survival was higher in women (p[logrank] = 0.0317). Logarithmic increase of NT-proBNP was a common independent predictor of death. Hypercholesterolemia and peripheral artery disease were predictors of death only in men while ischemic and dilative cardiomyopathy (CM) and age were predictors in women. Independent predictors of rehospitalization for heart failure were severely reduced ejection fraction and success in men while both ischemic and dilative CM, logistic EuroSCORE, and MR severity were predictive in women.CONCLUSIONS: Higher numbers of implanted clips and longer device time are likely related to more comorbidities in men. Procedural success and acute and mid-term clinical outcomes were equal. Superior survival for women in long-term analysis is presumably attributable to a comparatively better preprocedural health.",
keywords = "Aged, Aged, 80 and over, Cardiomyopathies/complications, Echocardiography/adverse effects, Female, Heart Failure/complications, Humans, Male, Middle Aged, Mitral Valve/physiopathology, Mitral Valve Insufficiency/complications, Postoperative Complications/epidemiology, Severity of Illness Index, Sex Characteristics, Treatment Outcome",
author = "Eike Tigges and Daniel Kalbacher and Christina Thomas and Sebastian Appelbaum and Florian Deuschl and Niklas Schofer and Michael Schl{\"u}ter and Lenard Conradi and Johannes Schirmer and Hendrik Treede and Hermann Reichenspurner and Stefan Blankenberg and Ulrich Sch{\"a}fer and Edith Lubos",
year = "2016",
doi = "10.1155/2016/3934842",
language = "English",
volume = "2016",
pages = "3934842",
journal = "BIOMED RES INT ",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Transcatheter Mitral Valve Repair in Surgical High-Risk Patients: Gender-Specific Acute and Long-Term Outcomes

AU - Tigges, Eike

AU - Kalbacher, Daniel

AU - Thomas, Christina

AU - Appelbaum, Sebastian

AU - Deuschl, Florian

AU - Schofer, Niklas

AU - Schlüter, Michael

AU - Conradi, Lenard

AU - Schirmer, Johannes

AU - Treede, Hendrik

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Schäfer, Ulrich

AU - Lubos, Edith

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Analyses emphasizing gender-related differences in acute and long-term outcomes following MitraClip therapy for significant mitral regurgitation (MR) are rare.METHODS: 592 consecutive patients (75 ± 8.7 years, 362 men, 230 women) underwent clinical and echocardiographic follow-up for a median of 2.13 (0.99-4.02) years.RESULTS: Significantly higher prevalence of cardiovascular comorbidities, renal failure, and adverse echocardiographic parameters in men resulted in longer device time (p = 0.007) and higher numbers of implanted clips (p = 0.0075), with equal procedural success (p = 1.0). Rehospitalization for heart failure did not differ (p[logrank] = 0.288) while survival was higher in women (p[logrank] = 0.0317). Logarithmic increase of NT-proBNP was a common independent predictor of death. Hypercholesterolemia and peripheral artery disease were predictors of death only in men while ischemic and dilative cardiomyopathy (CM) and age were predictors in women. Independent predictors of rehospitalization for heart failure were severely reduced ejection fraction and success in men while both ischemic and dilative CM, logistic EuroSCORE, and MR severity were predictive in women.CONCLUSIONS: Higher numbers of implanted clips and longer device time are likely related to more comorbidities in men. Procedural success and acute and mid-term clinical outcomes were equal. Superior survival for women in long-term analysis is presumably attributable to a comparatively better preprocedural health.

AB - BACKGROUND: Analyses emphasizing gender-related differences in acute and long-term outcomes following MitraClip therapy for significant mitral regurgitation (MR) are rare.METHODS: 592 consecutive patients (75 ± 8.7 years, 362 men, 230 women) underwent clinical and echocardiographic follow-up for a median of 2.13 (0.99-4.02) years.RESULTS: Significantly higher prevalence of cardiovascular comorbidities, renal failure, and adverse echocardiographic parameters in men resulted in longer device time (p = 0.007) and higher numbers of implanted clips (p = 0.0075), with equal procedural success (p = 1.0). Rehospitalization for heart failure did not differ (p[logrank] = 0.288) while survival was higher in women (p[logrank] = 0.0317). Logarithmic increase of NT-proBNP was a common independent predictor of death. Hypercholesterolemia and peripheral artery disease were predictors of death only in men while ischemic and dilative cardiomyopathy (CM) and age were predictors in women. Independent predictors of rehospitalization for heart failure were severely reduced ejection fraction and success in men while both ischemic and dilative CM, logistic EuroSCORE, and MR severity were predictive in women.CONCLUSIONS: Higher numbers of implanted clips and longer device time are likely related to more comorbidities in men. Procedural success and acute and mid-term clinical outcomes were equal. Superior survival for women in long-term analysis is presumably attributable to a comparatively better preprocedural health.

KW - Aged

KW - Aged, 80 and over

KW - Cardiomyopathies/complications

KW - Echocardiography/adverse effects

KW - Female

KW - Heart Failure/complications

KW - Humans

KW - Male

KW - Middle Aged

KW - Mitral Valve/physiopathology

KW - Mitral Valve Insufficiency/complications

KW - Postoperative Complications/epidemiology

KW - Severity of Illness Index

KW - Sex Characteristics

KW - Treatment Outcome

U2 - 10.1155/2016/3934842

DO - 10.1155/2016/3934842

M3 - SCORING: Journal article

C2 - 27042662

VL - 2016

SP - 3934842

JO - BIOMED RES INT

JF - BIOMED RES INT

SN - 2314-6133

ER -