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Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product.

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Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product. / Menzo, S; Clementi, M; Alfani, E; Bagnarelli, P; Iacovacci, S; Manzin, A; Dandri-Petersen, Maura; Natoli, G; Levrero, M; Carloni, G.

In: VIROLOGY, Vol. 196, No. 2, 2, 1993, p. 878-882.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Menzo, S, Clementi, M, Alfani, E, Bagnarelli, P, Iacovacci, S, Manzin, A, Dandri-Petersen, M, Natoli, G, Levrero, M & Carloni, G 1993, 'Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product.', VIROLOGY, vol. 196, no. 2, 2, pp. 878-882. <http://www.ncbi.nlm.nih.gov/pubmed/8396816?dopt=Citation>

APA

Menzo, S., Clementi, M., Alfani, E., Bagnarelli, P., Iacovacci, S., Manzin, A., Dandri-Petersen, M., Natoli, G., Levrero, M., & Carloni, G. (1993). Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product. VIROLOGY, 196(2), 878-882. [2]. http://www.ncbi.nlm.nih.gov/pubmed/8396816?dopt=Citation

Vancouver

Menzo S, Clementi M, Alfani E, Bagnarelli P, Iacovacci S, Manzin A et al. Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product. VIROLOGY. 1993;196(2):878-882. 2.

Bibtex

@article{6085299570924f54bed8c3dbf62c3723,
title = "Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product.",
abstract = "The expression of the cellular gene coding for the epidermal growth factor (EGF) receptor (EGF-R) was assayed in the presence of hepatitis B virus (HBV) gene expression under different experimental conditions in human hepatoma-derived cells. First, transfection experiments of the well-differentiated HepG2 human hepatoma cell line using different expression vectors of the HBV X-region demonstrated that the X-gene product is capable of inducing EGF-R gene overexpression; in addition, by using a stable in vitro expression system for HBV, it was shown that EGF-R gene expression in these cells is greater than in the uninfected parent cells, and that this results in a three-fold increase in 125I-EGF binding. Finally, a CAT-expression assay was performed, indicating that regulatory regions of the EGF-R-gene are target sequences for X-protein trans-activation.",
author = "S Menzo and M Clementi and E Alfani and P Bagnarelli and S Iacovacci and A Manzin and Maura Dandri-Petersen and G Natoli and M Levrero and G Carloni",
year = "1993",
language = "Deutsch",
volume = "196",
pages = "878--882",
journal = "VIROLOGY",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product.

AU - Menzo, S

AU - Clementi, M

AU - Alfani, E

AU - Bagnarelli, P

AU - Iacovacci, S

AU - Manzin, A

AU - Dandri-Petersen, Maura

AU - Natoli, G

AU - Levrero, M

AU - Carloni, G

PY - 1993

Y1 - 1993

N2 - The expression of the cellular gene coding for the epidermal growth factor (EGF) receptor (EGF-R) was assayed in the presence of hepatitis B virus (HBV) gene expression under different experimental conditions in human hepatoma-derived cells. First, transfection experiments of the well-differentiated HepG2 human hepatoma cell line using different expression vectors of the HBV X-region demonstrated that the X-gene product is capable of inducing EGF-R gene overexpression; in addition, by using a stable in vitro expression system for HBV, it was shown that EGF-R gene expression in these cells is greater than in the uninfected parent cells, and that this results in a three-fold increase in 125I-EGF binding. Finally, a CAT-expression assay was performed, indicating that regulatory regions of the EGF-R-gene are target sequences for X-protein trans-activation.

AB - The expression of the cellular gene coding for the epidermal growth factor (EGF) receptor (EGF-R) was assayed in the presence of hepatitis B virus (HBV) gene expression under different experimental conditions in human hepatoma-derived cells. First, transfection experiments of the well-differentiated HepG2 human hepatoma cell line using different expression vectors of the HBV X-region demonstrated that the X-gene product is capable of inducing EGF-R gene overexpression; in addition, by using a stable in vitro expression system for HBV, it was shown that EGF-R gene expression in these cells is greater than in the uninfected parent cells, and that this results in a three-fold increase in 125I-EGF binding. Finally, a CAT-expression assay was performed, indicating that regulatory regions of the EGF-R-gene are target sequences for X-protein trans-activation.

M3 - SCORING: Zeitschriftenaufsatz

VL - 196

SP - 878

EP - 882

JO - VIROLOGY

JF - VIROLOGY

SN - 0042-6822

IS - 2

M1 - 2

ER -