Toward evidence-based diagnosis of myocarditis in children and adolescents
Standard
Toward evidence-based diagnosis of myocarditis in children and adolescents : Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform. / Messroghli, Daniel R; Pickardt, Thomas; Fischer, Marcus; Opgen-Rhein, Bernd; Papakostas, Konstantin; Böcker, Dorothée; Jakob, André; Khalil, Markus; Mueller, Goetz C; Schmidt, Florian; Kaestner, Michael; Udink Ten Cate, Floris E A; Wagner, Robert; Ruf, Bettina; Kiski, Daniela; Wiegand, Gesa; Degener, Franziska; Bauer, Ulrike M M; Friede, Tim; Schubert, Stephan; MYKKE consortium.
In: AM HEART J, Vol. 187, 05.2017, p. 133-144.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Toward evidence-based diagnosis of myocarditis in children and adolescents
T2 - Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform
AU - Messroghli, Daniel R
AU - Pickardt, Thomas
AU - Fischer, Marcus
AU - Opgen-Rhein, Bernd
AU - Papakostas, Konstantin
AU - Böcker, Dorothée
AU - Jakob, André
AU - Khalil, Markus
AU - Mueller, Goetz C
AU - Schmidt, Florian
AU - Kaestner, Michael
AU - Udink Ten Cate, Floris E A
AU - Wagner, Robert
AU - Ruf, Bettina
AU - Kiski, Daniela
AU - Wiegand, Gesa
AU - Degener, Franziska
AU - Bauer, Ulrike M M
AU - Friede, Tim
AU - Schubert, Stephan
AU - MYKKE consortium
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/5
Y1 - 2017/5
N2 - The aim of this registry is to provide data on age-related clinical features of suspected myocarditis and to create a study platform allowing for deriving diagnostic criteria and, at a later stage, testing therapeutic interventions in patients with myocarditis.STUDY DESIGN AND RESULTS: After an initial 6-month pilot phase, MYKKE was opened in June 2014 as a prospective multicenter registry for patients from pediatric heart centers, university hospitals, and community hospitals with pediatric cardiology wards in Germany. Inclusion criteria consisted of age<18 years and hospitalization for suspected myocarditis as leading diagnosis at the discretion of the treating physician. By December 31, 2015, fifteen centers across Germany were actively participating and had enrolled 149 patients. Baseline data reveal 2 age peaks (<2 years, >12 years), show higher proportions of males, and document a high prevalence of severe disease courses in pediatric patients with suspected myocarditis. Severe clinical courses and early adverse events were more prevalent in younger patients and were related to severely impaired leftventricular ejection fraction at initial presentation.SUMMARY: MYKKE represents a multicenter registry and research platform for children and adolescents with suspected myocarditis that achieve steady recruitment and generate a wide range of real-world data on clinical course, diagnostic workup, and treatment of this group of patients. The baseline data reveal the presence of 2 age peaks and provide important insights into the severity of disease in children with suspected myocarditis. In the future, MYKKE might facilitate interventional substudies by providing an established collaborating network using common diagnostic approaches.
AB - The aim of this registry is to provide data on age-related clinical features of suspected myocarditis and to create a study platform allowing for deriving diagnostic criteria and, at a later stage, testing therapeutic interventions in patients with myocarditis.STUDY DESIGN AND RESULTS: After an initial 6-month pilot phase, MYKKE was opened in June 2014 as a prospective multicenter registry for patients from pediatric heart centers, university hospitals, and community hospitals with pediatric cardiology wards in Germany. Inclusion criteria consisted of age<18 years and hospitalization for suspected myocarditis as leading diagnosis at the discretion of the treating physician. By December 31, 2015, fifteen centers across Germany were actively participating and had enrolled 149 patients. Baseline data reveal 2 age peaks (<2 years, >12 years), show higher proportions of males, and document a high prevalence of severe disease courses in pediatric patients with suspected myocarditis. Severe clinical courses and early adverse events were more prevalent in younger patients and were related to severely impaired leftventricular ejection fraction at initial presentation.SUMMARY: MYKKE represents a multicenter registry and research platform for children and adolescents with suspected myocarditis that achieve steady recruitment and generate a wide range of real-world data on clinical course, diagnostic workup, and treatment of this group of patients. The baseline data reveal the presence of 2 age peaks and provide important insights into the severity of disease in children with suspected myocarditis. In the future, MYKKE might facilitate interventional substudies by providing an established collaborating network using common diagnostic approaches.
KW - Adolescent
KW - Age Factors
KW - Child
KW - Child, Preschool
KW - Female
KW - Germany
KW - Humans
KW - Male
KW - Myocarditis/diagnosis
KW - Prospective Studies
KW - Registries
KW - Research Design
KW - Severity of Illness Index
KW - Sex Factors
KW - Stroke Volume/physiology
U2 - 10.1016/j.ahj.2017.02.027
DO - 10.1016/j.ahj.2017.02.027
M3 - SCORING: Journal article
C2 - 28454797
VL - 187
SP - 133
EP - 144
JO - AM HEART J
JF - AM HEART J
SN - 0002-8703
ER -
