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Total aortic arch replacement: superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses

Standard

Total aortic arch replacement: superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses. / Weymann, Alexander; Radovits, Tamás; Schmack, Bastian; Korkmaz, Sevil; Li, Shiliang; Chaimow, Nicole; Pätzold, Ines; Becher, Peter Moritz; Hartyánszky, István; Soós, Pál; Merkely, Gergő; Németh, Balázs Tamás; Istók, Roland; Veres, Gábor; Merkely, Béla; Terytze, Konstantin; Karck, Matthias; Szabó, Gábor.

In: PLOS ONE, Vol. 9, No. 7, 2014, p. e103588.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weymann, A, Radovits, T, Schmack, B, Korkmaz, S, Li, S, Chaimow, N, Pätzold, I, Becher, PM, Hartyánszky, I, Soós, P, Merkely, G, Németh, BT, Istók, R, Veres, G, Merkely, B, Terytze, K, Karck, M & Szabó, G 2014, 'Total aortic arch replacement: superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses', PLOS ONE, vol. 9, no. 7, pp. e103588. https://doi.org/10.1371/journal.pone.0103588

APA

Weymann, A., Radovits, T., Schmack, B., Korkmaz, S., Li, S., Chaimow, N., Pätzold, I., Becher, P. M., Hartyánszky, I., Soós, P., Merkely, G., Németh, B. T., Istók, R., Veres, G., Merkely, B., Terytze, K., Karck, M., & Szabó, G. (2014). Total aortic arch replacement: superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses. PLOS ONE, 9(7), e103588. https://doi.org/10.1371/journal.pone.0103588

Vancouver

Weymann A, Radovits T, Schmack B, Korkmaz S, Li S, Chaimow N et al. Total aortic arch replacement: superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses. PLOS ONE. 2014;9(7):e103588. https://doi.org/10.1371/journal.pone.0103588

Bibtex

@article{4e5acafe926c4c6ea63e6da4295f468b,
title = "Total aortic arch replacement: superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses",
abstract = "BACKGROUND: To date, no experimental or clinical study provides detailed analysis of vascular impedance changes after total aortic arch replacement. This study investigated ventriculoarterial coupling and vascular impedance after replacement of the aortic arch with conventional prostheses vs. decellularized allografts.METHODS: After preparing decellularized aortic arch allografts, their mechanical, histological and biochemical properties were evaluated and compared to native aortic arches and conventional prostheses in vitro. In open-chest dogs, total aortic arch replacement was performed with conventional prostheses and compared to decellularized allografts (n = 5/group). Aortic flow and pressure were recorded continuously, left ventricular pressure-volume relations were measured by using a pressure-conductance catheter. From the hemodynamic variables end-systolic elastance (Ees), arterial elastance (Ea) and ventriculoarterial coupling were calculated. Characteristic impedance (Z) was assessed by Fourier analysis.RESULTS: While Ees did not differ between the groups and over time (4.1±1.19 vs. 4.58±1.39 mmHg/mL and 3.21±0.97 vs. 3.96±1.16 mmHg/mL), Ea showed a higher increase in the prosthesis group (4.01±0.67 vs. 6.18±0.20 mmHg/mL, P<0.05) in comparison to decellularized allografts (5.03±0.35 vs. 5.99±1.09 mmHg/mL). This led to impaired ventriculoarterial coupling in the prosthesis group, while it remained unchanged in the allograft group (62.5±50.9 vs. 3.9±23.4%). Z showed a strong increasing tendency in the prosthesis group and it was markedly higher after replacement when compared to decellularized allografts (44.6±8.3 dyn·sec·cm(-5) vs. 32.4±2.0 dyn·sec·cm(-5), P<0.05).CONCLUSIONS: Total aortic arch replacement leads to contractility-afterload mismatch by means of increased impedance and invert ventriculoarterial coupling ratio after implantation of conventional prostheses. Implantation of decellularized allografts preserves vascular impedance thereby improving ventriculoarterial mechanoenergetics after aortic arch replacement.",
keywords = "Allografts, Animals, Aorta, Thoracic/surgery, Aortic Diseases/physiopathology, Biomechanical Phenomena, Blood Vessel Prosthesis, Dogs, Female, Male, Myocardial Contraction, Vascular Resistance, Ventricular Pressure",
author = "Alexander Weymann and Tam{\'a}s Radovits and Bastian Schmack and Sevil Korkmaz and Shiliang Li and Nicole Chaimow and Ines P{\"a}tzold and Becher, {Peter Moritz} and Istv{\'a}n Harty{\'a}nszky and P{\'a}l So{\'o}s and Gerg{\H o} Merkely and N{\'e}meth, {Bal{\'a}zs Tam{\'a}s} and Roland Ist{\'o}k and G{\'a}bor Veres and B{\'e}la Merkely and Konstantin Terytze and Matthias Karck and G{\'a}bor Szab{\'o}",
year = "2014",
doi = "10.1371/journal.pone.0103588",
language = "English",
volume = "9",
pages = "e103588",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Total aortic arch replacement: superior ventriculo-arterial coupling with decellularized allografts compared with conventional prostheses

AU - Weymann, Alexander

AU - Radovits, Tamás

AU - Schmack, Bastian

AU - Korkmaz, Sevil

AU - Li, Shiliang

AU - Chaimow, Nicole

AU - Pätzold, Ines

AU - Becher, Peter Moritz

AU - Hartyánszky, István

AU - Soós, Pál

AU - Merkely, Gergő

AU - Németh, Balázs Tamás

AU - Istók, Roland

AU - Veres, Gábor

AU - Merkely, Béla

AU - Terytze, Konstantin

AU - Karck, Matthias

AU - Szabó, Gábor

PY - 2014

Y1 - 2014

N2 - BACKGROUND: To date, no experimental or clinical study provides detailed analysis of vascular impedance changes after total aortic arch replacement. This study investigated ventriculoarterial coupling and vascular impedance after replacement of the aortic arch with conventional prostheses vs. decellularized allografts.METHODS: After preparing decellularized aortic arch allografts, their mechanical, histological and biochemical properties were evaluated and compared to native aortic arches and conventional prostheses in vitro. In open-chest dogs, total aortic arch replacement was performed with conventional prostheses and compared to decellularized allografts (n = 5/group). Aortic flow and pressure were recorded continuously, left ventricular pressure-volume relations were measured by using a pressure-conductance catheter. From the hemodynamic variables end-systolic elastance (Ees), arterial elastance (Ea) and ventriculoarterial coupling were calculated. Characteristic impedance (Z) was assessed by Fourier analysis.RESULTS: While Ees did not differ between the groups and over time (4.1±1.19 vs. 4.58±1.39 mmHg/mL and 3.21±0.97 vs. 3.96±1.16 mmHg/mL), Ea showed a higher increase in the prosthesis group (4.01±0.67 vs. 6.18±0.20 mmHg/mL, P<0.05) in comparison to decellularized allografts (5.03±0.35 vs. 5.99±1.09 mmHg/mL). This led to impaired ventriculoarterial coupling in the prosthesis group, while it remained unchanged in the allograft group (62.5±50.9 vs. 3.9±23.4%). Z showed a strong increasing tendency in the prosthesis group and it was markedly higher after replacement when compared to decellularized allografts (44.6±8.3 dyn·sec·cm(-5) vs. 32.4±2.0 dyn·sec·cm(-5), P<0.05).CONCLUSIONS: Total aortic arch replacement leads to contractility-afterload mismatch by means of increased impedance and invert ventriculoarterial coupling ratio after implantation of conventional prostheses. Implantation of decellularized allografts preserves vascular impedance thereby improving ventriculoarterial mechanoenergetics after aortic arch replacement.

AB - BACKGROUND: To date, no experimental or clinical study provides detailed analysis of vascular impedance changes after total aortic arch replacement. This study investigated ventriculoarterial coupling and vascular impedance after replacement of the aortic arch with conventional prostheses vs. decellularized allografts.METHODS: After preparing decellularized aortic arch allografts, their mechanical, histological and biochemical properties were evaluated and compared to native aortic arches and conventional prostheses in vitro. In open-chest dogs, total aortic arch replacement was performed with conventional prostheses and compared to decellularized allografts (n = 5/group). Aortic flow and pressure were recorded continuously, left ventricular pressure-volume relations were measured by using a pressure-conductance catheter. From the hemodynamic variables end-systolic elastance (Ees), arterial elastance (Ea) and ventriculoarterial coupling were calculated. Characteristic impedance (Z) was assessed by Fourier analysis.RESULTS: While Ees did not differ between the groups and over time (4.1±1.19 vs. 4.58±1.39 mmHg/mL and 3.21±0.97 vs. 3.96±1.16 mmHg/mL), Ea showed a higher increase in the prosthesis group (4.01±0.67 vs. 6.18±0.20 mmHg/mL, P<0.05) in comparison to decellularized allografts (5.03±0.35 vs. 5.99±1.09 mmHg/mL). This led to impaired ventriculoarterial coupling in the prosthesis group, while it remained unchanged in the allograft group (62.5±50.9 vs. 3.9±23.4%). Z showed a strong increasing tendency in the prosthesis group and it was markedly higher after replacement when compared to decellularized allografts (44.6±8.3 dyn·sec·cm(-5) vs. 32.4±2.0 dyn·sec·cm(-5), P<0.05).CONCLUSIONS: Total aortic arch replacement leads to contractility-afterload mismatch by means of increased impedance and invert ventriculoarterial coupling ratio after implantation of conventional prostheses. Implantation of decellularized allografts preserves vascular impedance thereby improving ventriculoarterial mechanoenergetics after aortic arch replacement.

KW - Allografts

KW - Animals

KW - Aorta, Thoracic/surgery

KW - Aortic Diseases/physiopathology

KW - Biomechanical Phenomena

KW - Blood Vessel Prosthesis

KW - Dogs

KW - Female

KW - Male

KW - Myocardial Contraction

KW - Vascular Resistance

KW - Ventricular Pressure

U2 - 10.1371/journal.pone.0103588

DO - 10.1371/journal.pone.0103588

M3 - SCORING: Journal article

C2 - 25079587

VL - 9

SP - e103588

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 7

ER -