Topology of psoriasis in routine care: results from high-resolution analysis of 2009 patients
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Topology of psoriasis in routine care: results from high-resolution analysis of 2009 patients. / Augustin, M; Sommer, R; Kirsten, N; Danckworth, A; Radtke, M A; Reich, K; Thaci, D; Boehncke, W H; Langenbruch, A; Mrowietz, U.
In: BRIT J DERMATOL, Vol. 181, No. 2, 08.2019, p. 358-365.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Topology of psoriasis in routine care: results from high-resolution analysis of 2009 patients
AU - Augustin, M
AU - Sommer, R
AU - Kirsten, N
AU - Danckworth, A
AU - Radtke, M A
AU - Reich, K
AU - Thaci, D
AU - Boehncke, W H
AU - Langenbruch, A
AU - Mrowietz, U
N1 - © 2018 British Association of Dermatologists.
PY - 2019/8
Y1 - 2019/8
N2 - BACKGROUND: Different phenotypes have been described in psoriasis. Few details are known about the topology of patients in routine care.OBJECTIVES: To characterize the frequency and distribution of body sites affected by psoriasis in Germany.METHODS: Data from a national cross-sectional study (PsoHealth2) were analysed. Each practice consecutively recruited 20 patients independently of treatment. Topical distribution was identified with a detailed grid scheme of 1424 squares filled by the patient. Psoriasis history, clinical findings, comorbidity and patient-reported outcomes were obtained.RESULTS: In total, 2009 patients with psoriasis were observed. Nineteen per cent of patients had psoriatic arthritis, 65·4% had scalp involvement and 35·6% had nail involvement; in 40·5% of patients, their first-degree relatives also had psoriasis. In total, 1927 (95·9%) provided complete grid data. The mean number of grids marked was 152·4 ± 193·2, corresponding to 10·7% of body surface area. The most frequently affected body areas were the elbows, knees, lower legs and scalp (65-78%). In a linear regression analysis (corrected R² = 0·093), the strongest predictors of reductions in health-related quality of life (HRQoL), measured by the Dermatology Life Quality Index, were having the hands (β = 0·147; P = 0·000), arms (β = 0·097; P = 0·008), genitals (β = 0·080; P = 0·010), neck (β = -0·072; P = 0·043), scalp (β = 0·068; P = 0·010) and nails affected (β = 0·064; P = 0·005).CONCLUSIONS: Typical psoriatic lesions are found in real-world care. However, smaller areas are important determinants of reductions in HRQoL.
AB - BACKGROUND: Different phenotypes have been described in psoriasis. Few details are known about the topology of patients in routine care.OBJECTIVES: To characterize the frequency and distribution of body sites affected by psoriasis in Germany.METHODS: Data from a national cross-sectional study (PsoHealth2) were analysed. Each practice consecutively recruited 20 patients independently of treatment. Topical distribution was identified with a detailed grid scheme of 1424 squares filled by the patient. Psoriasis history, clinical findings, comorbidity and patient-reported outcomes were obtained.RESULTS: In total, 2009 patients with psoriasis were observed. Nineteen per cent of patients had psoriatic arthritis, 65·4% had scalp involvement and 35·6% had nail involvement; in 40·5% of patients, their first-degree relatives also had psoriasis. In total, 1927 (95·9%) provided complete grid data. The mean number of grids marked was 152·4 ± 193·2, corresponding to 10·7% of body surface area. The most frequently affected body areas were the elbows, knees, lower legs and scalp (65-78%). In a linear regression analysis (corrected R² = 0·093), the strongest predictors of reductions in health-related quality of life (HRQoL), measured by the Dermatology Life Quality Index, were having the hands (β = 0·147; P = 0·000), arms (β = 0·097; P = 0·008), genitals (β = 0·080; P = 0·010), neck (β = -0·072; P = 0·043), scalp (β = 0·068; P = 0·010) and nails affected (β = 0·064; P = 0·005).CONCLUSIONS: Typical psoriatic lesions are found in real-world care. However, smaller areas are important determinants of reductions in HRQoL.
KW - Journal Article
U2 - 10.1111/bjd.17403
DO - 10.1111/bjd.17403
M3 - SCORING: Journal article
C2 - 30430557
VL - 181
SP - 358
EP - 365
JO - BRIT J DERMATOL
JF - BRIT J DERMATOL
SN - 0007-0963
IS - 2
ER -