Topographical mapping of the mechanical characteristics of the human neurocranium considering the role of individual layers
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Topographical mapping of the mechanical characteristics of the human neurocranium considering the role of individual layers. / Zwirner, Johann; Safavi, Sarah; Scholze, Mario; Li, Kai Chun; Waddell, John Neil; Busse, Björn; Ondruschka, Benjamin; Hammer, Niels.
In: SCI REP-UK, Vol. 11, No. 1, 3721, 12.02.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Topographical mapping of the mechanical characteristics of the human neurocranium considering the role of individual layers
AU - Zwirner, Johann
AU - Safavi, Sarah
AU - Scholze, Mario
AU - Li, Kai Chun
AU - Waddell, John Neil
AU - Busse, Björn
AU - Ondruschka, Benjamin
AU - Hammer, Niels
PY - 2021/2/12
Y1 - 2021/2/12
N2 - The site-dependent load-deformation behavior of the human neurocranium and the load dissipation within the three-layered composite is not well understood. This study mechanically investigated 257 human frontal, temporal, parietal and occipital neurocranial bone samples at an age range of 2 to 94 years, using three-point bending tests. Samples were tested as full-thickness three-layered composites, as well as separated with both diploë attached and removed. Right temporal samples were the thinnest samples of all tested regions (median < 5 mm; p < 0.001) and withstood lowest failure loads (median < 762 N; p < 0.001). Outer tables were thicker and showed higher failure loads (median 2.4 mm; median 264 N) than inner tables (median 1.7 mm, p < 0.001; median 132 N, p = 0.003). The presence of diploë attached to outer and inner tables led to a significant reduction in bending strength (with diploë: median < 60 MPa; without diploë: median > 90 MPa, p < 0.001). Composites (r = 0.243, p = 0.011) and inner tables with attached diploë (r = 0.214, p = 0.032) revealed positive correlations between sample thickness and age. The three-layered composite is four times more load-resistant compared to the outer table and eight times more compared to the inner table.
AB - The site-dependent load-deformation behavior of the human neurocranium and the load dissipation within the three-layered composite is not well understood. This study mechanically investigated 257 human frontal, temporal, parietal and occipital neurocranial bone samples at an age range of 2 to 94 years, using three-point bending tests. Samples were tested as full-thickness three-layered composites, as well as separated with both diploë attached and removed. Right temporal samples were the thinnest samples of all tested regions (median < 5 mm; p < 0.001) and withstood lowest failure loads (median < 762 N; p < 0.001). Outer tables were thicker and showed higher failure loads (median 2.4 mm; median 264 N) than inner tables (median 1.7 mm, p < 0.001; median 132 N, p = 0.003). The presence of diploë attached to outer and inner tables led to a significant reduction in bending strength (with diploë: median < 60 MPa; without diploë: median > 90 MPa, p < 0.001). Composites (r = 0.243, p = 0.011) and inner tables with attached diploë (r = 0.214, p = 0.032) revealed positive correlations between sample thickness and age. The three-layered composite is four times more load-resistant compared to the outer table and eight times more compared to the inner table.
U2 - 10.1038/s41598-020-80548-y
DO - 10.1038/s41598-020-80548-y
M3 - SCORING: Journal article
C2 - 33580114
VL - 11
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
M1 - 3721
ER -
