Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer.
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Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer. / Haubold, Katja; Rink, Michael; Spath, Brigitte; Friedrich, Martin; Chun, Felix; Marx, Guy; Amirkhosravi, Ali; Francis, John L; Bokemeyer, Carsten; Eifrig, Barbara; Langer, Florian.
In: THROMB HAEMOSTASIS, Vol. 101, No. 6, 6, 2009, p. 1147-1155.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer.
AU - Haubold, Katja
AU - Rink, Michael
AU - Spath, Brigitte
AU - Friedrich, Martin
AU - Chun, Felix
AU - Marx, Guy
AU - Amirkhosravi, Ali
AU - Francis, John L
AU - Bokemeyer, Carsten
AU - Eifrig, Barbara
AU - Langer, Florian
PY - 2009
Y1 - 2009
N2 - Tissue factor (TF) plays a critical role in tumour growth and metastasis, and its enhanced release into plasma in association with cellular microparticles (MPs) has recently been associated with pathological cancer progression. We have previously demonstrated significantly elevated levels of plasma TF antigen as well as systemic coagulation and platelet activation in patients with localised prostate cancer. In this prospective study, we used a highly sensitive one-stage clotting assay to measure preoperative TF-specific procoagulant activity (PCA) of plasma MPs in 68 consecutive patients with early-stage prostate cancer to further explore the relevance of circulating TF in this tumour entity. Automated calibrated thrombography was used to monitor thrombin generation in cell-free plasma samples in the absence of exogenous TF or phospholipids. Compared to healthy male controls (n=20), patients had significantly increased levels of both D-dimer and TF-specific PCA of plasma MPs (p
AB - Tissue factor (TF) plays a critical role in tumour growth and metastasis, and its enhanced release into plasma in association with cellular microparticles (MPs) has recently been associated with pathological cancer progression. We have previously demonstrated significantly elevated levels of plasma TF antigen as well as systemic coagulation and platelet activation in patients with localised prostate cancer. In this prospective study, we used a highly sensitive one-stage clotting assay to measure preoperative TF-specific procoagulant activity (PCA) of plasma MPs in 68 consecutive patients with early-stage prostate cancer to further explore the relevance of circulating TF in this tumour entity. Automated calibrated thrombography was used to monitor thrombin generation in cell-free plasma samples in the absence of exogenous TF or phospholipids. Compared to healthy male controls (n=20), patients had significantly increased levels of both D-dimer and TF-specific PCA of plasma MPs (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 101
SP - 1147
EP - 1155
JO - THROMB HAEMOSTASIS
JF - THROMB HAEMOSTASIS
SN - 0340-6245
IS - 6
M1 - 6
ER -
