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TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature

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TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature. / Nordmann, Tamara; Schlabe, Stefan; Feldt, Torsten; Gobbi, Federico; Krieg, Andreas; Bode, Johannes G; Fuchs, Andre; Kraef, Christian; Praktiknjo, Michael; Trebicka, Jonel; Ramharter, Michael; Addo, Marylyn M; Strassburg, Christian; Lohse, Ansgar W; Luedde, Tom; Schmiedel, Stefan; Orth, Hans Martin.

In: PLOS NEGLECT TROP D, Vol. 15, No. 12, e0010065, 12.2021.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Nordmann, T, Schlabe, S, Feldt, T, Gobbi, F, Krieg, A, Bode, JG, Fuchs, A, Kraef, C, Praktiknjo, M, Trebicka, J, Ramharter, M, Addo, MM, Strassburg, C, Lohse, AW, Luedde, T, Schmiedel, S & Orth, HM 2021, 'TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature', PLOS NEGLECT TROP D, vol. 15, no. 12, e0010065. https://doi.org/10.1371/journal.pntd.0010065

APA

Nordmann, T., Schlabe, S., Feldt, T., Gobbi, F., Krieg, A., Bode, J. G., Fuchs, A., Kraef, C., Praktiknjo, M., Trebicka, J., Ramharter, M., Addo, M. M., Strassburg, C., Lohse, A. W., Luedde, T., Schmiedel, S., & Orth, H. M. (2021). TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature. PLOS NEGLECT TROP D, 15(12), [e0010065]. https://doi.org/10.1371/journal.pntd.0010065

Vancouver

Nordmann T, Schlabe S, Feldt T, Gobbi F, Krieg A, Bode JG et al. TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature. PLOS NEGLECT TROP D. 2021 Dec;15(12). e0010065. https://doi.org/10.1371/journal.pntd.0010065

Bibtex

@article{9c5e3c9a91614878b99cda9fb94bf5b6,
title = "TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature",
abstract = "BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) and shunt surgery are established treatment options for portal hypertension, but have not been systematically evaluated in patients with portal hypertension due to hepatosplenic schistosomiasis (HSS), one of the neglected tropical diseases with major impact on morbidity and mortality in endemic areas.METHODS: In this retrospective case study, patients with chronic portal hypertension due to schistosomiasis treated with those therapeutic approaches in four tertiary referral hospitals in Germany and Italy between 2012 and 2020 were included. We have summarized pre-interventional clinical data, indication, technical aspects of the interventions and clinical outcome.FINDINGS: Overall, 13 patients with confirmed HSS were included. 11 patients received TIPS for primary or secondary prophylaxis of variceal bleeding due to advanced portal hypertension and failure of conservative management. In two patients with contraindications for TIPS or technically unsuccessful TIPS procedure, proximal splenorenal shunt surgery in combination with splenectomy was conducted. During follow-up (mean follow-up 23 months, cumulative follow-up time 31 patient years) no bleeding events were documented. In five patients, moderate and transient episodes of overt hepatic encephalopathy were observed. In one patient each, liver failure, portal vein thrombosis and catheter associated sepsis occurred after TIPS insertion. All complications were well manageable and had favorable outcomes.CONCLUSIONS: TIPS implantation and shunt surgery are safe and effective treatment options for patients with advanced HSS and sequelae of portal hypertension in experienced centers, but require careful patient selection.",
keywords = "Adolescent, Adult, Animals, Female, Follow-Up Studies, Germany, Humans, Hypertension, Portal/etiology, Italy, Liver Diseases/complications, Male, Middle Aged, Portasystemic Shunt, Transjugular Intrahepatic, Retrospective Studies, Schistosoma/physiology, Schistosomiasis/complications, Splenectomy, Splenic Diseases/complications, Splenorenal Shunt, Surgical, Treatment Outcome, Young Adult",
author = "Tamara Nordmann and Stefan Schlabe and Torsten Feldt and Federico Gobbi and Andreas Krieg and Bode, {Johannes G} and Andre Fuchs and Christian Kraef and Michael Praktiknjo and Jonel Trebicka and Michael Ramharter and Addo, {Marylyn M} and Christian Strassburg and Lohse, {Ansgar W} and Tom Luedde and Stefan Schmiedel and Orth, {Hans Martin}",
year = "2021",
month = dec,
doi = "10.1371/journal.pntd.0010065",
language = "English",
volume = "15",
journal = "PLOS NEGLECT TROP D",
issn = "1935-2735",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - TIPS and splenorenal shunt for complications of portal hypertension in chronic hepatosplenic schistosomiasis-A case series and review of the literature

AU - Nordmann, Tamara

AU - Schlabe, Stefan

AU - Feldt, Torsten

AU - Gobbi, Federico

AU - Krieg, Andreas

AU - Bode, Johannes G

AU - Fuchs, Andre

AU - Kraef, Christian

AU - Praktiknjo, Michael

AU - Trebicka, Jonel

AU - Ramharter, Michael

AU - Addo, Marylyn M

AU - Strassburg, Christian

AU - Lohse, Ansgar W

AU - Luedde, Tom

AU - Schmiedel, Stefan

AU - Orth, Hans Martin

PY - 2021/12

Y1 - 2021/12

N2 - BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) and shunt surgery are established treatment options for portal hypertension, but have not been systematically evaluated in patients with portal hypertension due to hepatosplenic schistosomiasis (HSS), one of the neglected tropical diseases with major impact on morbidity and mortality in endemic areas.METHODS: In this retrospective case study, patients with chronic portal hypertension due to schistosomiasis treated with those therapeutic approaches in four tertiary referral hospitals in Germany and Italy between 2012 and 2020 were included. We have summarized pre-interventional clinical data, indication, technical aspects of the interventions and clinical outcome.FINDINGS: Overall, 13 patients with confirmed HSS were included. 11 patients received TIPS for primary or secondary prophylaxis of variceal bleeding due to advanced portal hypertension and failure of conservative management. In two patients with contraindications for TIPS or technically unsuccessful TIPS procedure, proximal splenorenal shunt surgery in combination with splenectomy was conducted. During follow-up (mean follow-up 23 months, cumulative follow-up time 31 patient years) no bleeding events were documented. In five patients, moderate and transient episodes of overt hepatic encephalopathy were observed. In one patient each, liver failure, portal vein thrombosis and catheter associated sepsis occurred after TIPS insertion. All complications were well manageable and had favorable outcomes.CONCLUSIONS: TIPS implantation and shunt surgery are safe and effective treatment options for patients with advanced HSS and sequelae of portal hypertension in experienced centers, but require careful patient selection.

AB - BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) and shunt surgery are established treatment options for portal hypertension, but have not been systematically evaluated in patients with portal hypertension due to hepatosplenic schistosomiasis (HSS), one of the neglected tropical diseases with major impact on morbidity and mortality in endemic areas.METHODS: In this retrospective case study, patients with chronic portal hypertension due to schistosomiasis treated with those therapeutic approaches in four tertiary referral hospitals in Germany and Italy between 2012 and 2020 were included. We have summarized pre-interventional clinical data, indication, technical aspects of the interventions and clinical outcome.FINDINGS: Overall, 13 patients with confirmed HSS were included. 11 patients received TIPS for primary or secondary prophylaxis of variceal bleeding due to advanced portal hypertension and failure of conservative management. In two patients with contraindications for TIPS or technically unsuccessful TIPS procedure, proximal splenorenal shunt surgery in combination with splenectomy was conducted. During follow-up (mean follow-up 23 months, cumulative follow-up time 31 patient years) no bleeding events were documented. In five patients, moderate and transient episodes of overt hepatic encephalopathy were observed. In one patient each, liver failure, portal vein thrombosis and catheter associated sepsis occurred after TIPS insertion. All complications were well manageable and had favorable outcomes.CONCLUSIONS: TIPS implantation and shunt surgery are safe and effective treatment options for patients with advanced HSS and sequelae of portal hypertension in experienced centers, but require careful patient selection.

KW - Adolescent

KW - Adult

KW - Animals

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Humans

KW - Hypertension, Portal/etiology

KW - Italy

KW - Liver Diseases/complications

KW - Male

KW - Middle Aged

KW - Portasystemic Shunt, Transjugular Intrahepatic

KW - Retrospective Studies

KW - Schistosoma/physiology

KW - Schistosomiasis/complications

KW - Splenectomy

KW - Splenic Diseases/complications

KW - Splenorenal Shunt, Surgical

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1371/journal.pntd.0010065

DO - 10.1371/journal.pntd.0010065

M3 - SCORING: Review article

C2 - 34932562

VL - 15

JO - PLOS NEGLECT TROP D

JF - PLOS NEGLECT TROP D

SN - 1935-2735

IS - 12

M1 - e0010065

ER -