Time-updated resting heart rate predicts mortality in patients with COPD
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Time-updated resting heart rate predicts mortality in patients with COPD. / Omlor, Albert J; Trudzinski, Franziska C; Alqudrah, Mohamad; Seiler, Frederik; Biertz, Frank; Vogelmeier, Claus F; Welte, Tobias; Watz, Henrik; Waschki, Benjamin; Brinker, Titus J; Andreas, Stefan; Fähndrich, Sebastian; Alter, Peter; Jörres, Rudolf A; Böhm, Michael; Bals, Robert; German COSYCONET Cohort.
In: CLIN RES CARDIOL, Vol. 109, No. 6, 01.06.2020, p. 776-786.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Time-updated resting heart rate predicts mortality in patients with COPD
AU - Omlor, Albert J
AU - Trudzinski, Franziska C
AU - Alqudrah, Mohamad
AU - Seiler, Frederik
AU - Biertz, Frank
AU - Vogelmeier, Claus F
AU - Welte, Tobias
AU - Watz, Henrik
AU - Waschki, Benjamin
AU - Brinker, Titus J
AU - Andreas, Stefan
AU - Fähndrich, Sebastian
AU - Alter, Peter
AU - Jörres, Rudolf A
AU - Böhm, Michael
AU - Bals, Robert
AU - German COSYCONET Cohort
PY - 2020/6/1
Y1 - 2020/6/1
N2 - High resting heart rate (RHR) is associated with higher mortality in the general population and in cardiovascular disease. Less is known about the association of RHR with outcome in chronic obstructive pulmonary disease (COPD). In particular, the time-updated RHR (most recent value before the event) appears informative. This is the first study to investigate the association of time-updated RHR with mortality in COPD. We compared the baseline and time-updated RHR related to survival in 2218 COPD patients of the German COSYCONET cohort (COPD and Systemic Consequences-Comorbidities Network). Patients with a baseline RHR > 72 beats per minute (bmp) had a significantly (p = 0.049) higher all-cause mortality risk (adjusted hazard ratio (HR) of 1.37 (1.00-1.87) compared to baseline RHR ≤ 72 bpm. The time-updated RHR > 72 bpm was markedly superior (HR 1.79, 1.30-2.46, p = 0.001). Both, increased baseline and time-updated RHR, were independently associated with low FEV1, low TLCO, a history of diabetes, and medication with short-acting beta agonists (SABAs). In conclusion, increased time-updated RHR is associated with higher mortality in COPD independent of other predictors and superior to baseline RHR. Increased RHR is linked to lung function, comorbidities and medication. Whether RHR is an effective treatment target in COPD, needs to be proven in controlled trials.
AB - High resting heart rate (RHR) is associated with higher mortality in the general population and in cardiovascular disease. Less is known about the association of RHR with outcome in chronic obstructive pulmonary disease (COPD). In particular, the time-updated RHR (most recent value before the event) appears informative. This is the first study to investigate the association of time-updated RHR with mortality in COPD. We compared the baseline and time-updated RHR related to survival in 2218 COPD patients of the German COSYCONET cohort (COPD and Systemic Consequences-Comorbidities Network). Patients with a baseline RHR > 72 beats per minute (bmp) had a significantly (p = 0.049) higher all-cause mortality risk (adjusted hazard ratio (HR) of 1.37 (1.00-1.87) compared to baseline RHR ≤ 72 bpm. The time-updated RHR > 72 bpm was markedly superior (HR 1.79, 1.30-2.46, p = 0.001). Both, increased baseline and time-updated RHR, were independently associated with low FEV1, low TLCO, a history of diabetes, and medication with short-acting beta agonists (SABAs). In conclusion, increased time-updated RHR is associated with higher mortality in COPD independent of other predictors and superior to baseline RHR. Increased RHR is linked to lung function, comorbidities and medication. Whether RHR is an effective treatment target in COPD, needs to be proven in controlled trials.
KW - Aged
KW - Cause of Death/trends
KW - Female
KW - Follow-Up Studies
KW - Germany/epidemiology
KW - Heart Rate/physiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Prospective Studies
KW - Pulmonary Disease, Chronic Obstructive/mortality
KW - Rest/physiology
KW - Risk Factors
KW - Survival Rate/trends
KW - Time Factors
U2 - 10.1007/s00392-019-01572-1
DO - 10.1007/s00392-019-01572-1
M3 - SCORING: Journal article
C2 - 31734762
VL - 109
SP - 776
EP - 786
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 6
ER -