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Time-dependent memory transformation in hippocampus and neocortex is semantic in nature

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Time-dependent memory transformation in hippocampus and neocortex is semantic in nature. / Krenz, Valentina; Alink, Arjen; Sommer, Tobias; Roozendaal, Benno; Schwabe, Lars.

In: NAT COMMUN, Vol. 14, No. 1, 6037, 27.09.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Krenz, V, Alink, A, Sommer, T, Roozendaal, B & Schwabe, L 2023, 'Time-dependent memory transformation in hippocampus and neocortex is semantic in nature', NAT COMMUN, vol. 14, no. 1, 6037. https://doi.org/10.1038/s41467-023-41648-1

APA

Krenz, V., Alink, A., Sommer, T., Roozendaal, B., & Schwabe, L. (2023). Time-dependent memory transformation in hippocampus and neocortex is semantic in nature. NAT COMMUN, 14(1), [6037]. https://doi.org/10.1038/s41467-023-41648-1

Vancouver

Krenz V, Alink A, Sommer T, Roozendaal B, Schwabe L. Time-dependent memory transformation in hippocampus and neocortex is semantic in nature. NAT COMMUN. 2023 Sep 27;14(1). 6037. https://doi.org/10.1038/s41467-023-41648-1

Bibtex

@article{f2389fc20f6b40bb97735f1628cc813f,
title = "Time-dependent memory transformation in hippocampus and neocortex is semantic in nature",
abstract = "Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. Here, we report that the time-dependent transformation of memory is semantic in nature, while we find no credible evidence for a perceptual transformation. Model-based MRI analyses reveal time-dependent increases in semantically transformed representations of events in prefrontal and parietal cortices, while specific pattern representations in the anterior hippocampus decline over time. Posterior hippocampal memory reinstatement, in turn, increases over time and is linked to the semantic gist of the original memory, without a statistically significant link to perceptual details. These findings indicate that qualitative changes in memory over time, associated with distinct representational changes in the neocortex and within the hippocampus, reflect a semantic transformation, which may promote the integration of memories into abstract knowledge structures.",
author = "Valentina Krenz and Arjen Alink and Tobias Sommer and Benno Roozendaal and Lars Schwabe",
note = "{\textcopyright} 2023. Springer Nature Limited.",
year = "2023",
month = sep,
day = "27",
doi = "10.1038/s41467-023-41648-1",
language = "English",
volume = "14",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Time-dependent memory transformation in hippocampus and neocortex is semantic in nature

AU - Krenz, Valentina

AU - Alink, Arjen

AU - Sommer, Tobias

AU - Roozendaal, Benno

AU - Schwabe, Lars

N1 - © 2023. Springer Nature Limited.

PY - 2023/9/27

Y1 - 2023/9/27

N2 - Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. Here, we report that the time-dependent transformation of memory is semantic in nature, while we find no credible evidence for a perceptual transformation. Model-based MRI analyses reveal time-dependent increases in semantically transformed representations of events in prefrontal and parietal cortices, while specific pattern representations in the anterior hippocampus decline over time. Posterior hippocampal memory reinstatement, in turn, increases over time and is linked to the semantic gist of the original memory, without a statistically significant link to perceptual details. These findings indicate that qualitative changes in memory over time, associated with distinct representational changes in the neocortex and within the hippocampus, reflect a semantic transformation, which may promote the integration of memories into abstract knowledge structures.

AB - Memories undergo a time-dependent neural reorganization, which is assumed to be accompanied by a transformation from detailed to more gist-like memory. However, the nature of this transformation and its underlying neural mechanisms are largely unknown. Here, we report that the time-dependent transformation of memory is semantic in nature, while we find no credible evidence for a perceptual transformation. Model-based MRI analyses reveal time-dependent increases in semantically transformed representations of events in prefrontal and parietal cortices, while specific pattern representations in the anterior hippocampus decline over time. Posterior hippocampal memory reinstatement, in turn, increases over time and is linked to the semantic gist of the original memory, without a statistically significant link to perceptual details. These findings indicate that qualitative changes in memory over time, associated with distinct representational changes in the neocortex and within the hippocampus, reflect a semantic transformation, which may promote the integration of memories into abstract knowledge structures.

U2 - 10.1038/s41467-023-41648-1

DO - 10.1038/s41467-023-41648-1

M3 - SCORING: Journal article

C2 - 37758725

VL - 14

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 6037

ER -