Time trends of vitamin D concentrations in northern Sweden between 1986 and 2014: a population-based cross-sectional study
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Time trends of vitamin D concentrations in northern Sweden between 1986 and 2014: a population-based cross-sectional study. / Summerhays, Eva; Eliasson, Mats; Lundqvist, Robert; Söderberg, Stefan; Zeller, Tanja; Oskarsson, Viktor.
In: EUR J NUTR, Vol. 59, No. 7, 01.10.2020, p. 3037-3044.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Time trends of vitamin D concentrations in northern Sweden between 1986 and 2014: a population-based cross-sectional study
AU - Summerhays, Eva
AU - Eliasson, Mats
AU - Lundqvist, Robert
AU - Söderberg, Stefan
AU - Zeller, Tanja
AU - Oskarsson, Viktor
PY - 2020/10/1
Y1 - 2020/10/1
N2 - PURPOSE: Vitamin D, produced through cutaneous photosynthesis or ingested via foods or supplements, has generated considerable research interest due to its potential health effects. However, epidemiological data on the time trends of vitamin D status are sparse, especially from northern Europe. We examined the time trend of vitamin D concentrations in northern Sweden between 1986 and 2014.METHODS: We used data on 11,129 men and women (aged 25-74 years) from seven population-based surveys (the Northern Sweden MONICA study), recruited between 1986 and 2014. Serum vitamin D (25-hydroxyvitamin D) status was measured using a one-step immunoassay (Abbott Architect). Multivariable linear regression models, adjusted for age, sex, and a number of other variables, were used to estimate the time trend of vitamin D concentrations.RESULTS: The mean value of vitamin D in the entire study population was 19.9 ng/mL [standard deviation (SD) 7.9], with lower values in men (19.4 ng/mL; SD 7.5) than in women (20.5 ng/mL; SD 8.2). Using the survey in 1986 as reference category, the multivariable-adjusted mean difference [95% confidence interval (CI)] in ng/mL was 2.7 (2.2, 3.3) in 1990, 3.2 (2.7, 3.7) in 1994, 1.6 (1.0, 2.1) in 1999, - 2.0 (- 2.5, - 1.4) in 2004, 1.0 (0.4, 1.5) in 2009, and 3.1 (2.5, 3.6) in 2014.CONCLUSION: In this large cross-sectional study, we observed no clear upward or downward trend of vitamin D concentrations in northern Sweden between 1986 and 2014.
AB - PURPOSE: Vitamin D, produced through cutaneous photosynthesis or ingested via foods or supplements, has generated considerable research interest due to its potential health effects. However, epidemiological data on the time trends of vitamin D status are sparse, especially from northern Europe. We examined the time trend of vitamin D concentrations in northern Sweden between 1986 and 2014.METHODS: We used data on 11,129 men and women (aged 25-74 years) from seven population-based surveys (the Northern Sweden MONICA study), recruited between 1986 and 2014. Serum vitamin D (25-hydroxyvitamin D) status was measured using a one-step immunoassay (Abbott Architect). Multivariable linear regression models, adjusted for age, sex, and a number of other variables, were used to estimate the time trend of vitamin D concentrations.RESULTS: The mean value of vitamin D in the entire study population was 19.9 ng/mL [standard deviation (SD) 7.9], with lower values in men (19.4 ng/mL; SD 7.5) than in women (20.5 ng/mL; SD 8.2). Using the survey in 1986 as reference category, the multivariable-adjusted mean difference [95% confidence interval (CI)] in ng/mL was 2.7 (2.2, 3.3) in 1990, 3.2 (2.7, 3.7) in 1994, 1.6 (1.0, 2.1) in 1999, - 2.0 (- 2.5, - 1.4) in 2004, 1.0 (0.4, 1.5) in 2009, and 3.1 (2.5, 3.6) in 2014.CONCLUSION: In this large cross-sectional study, we observed no clear upward or downward trend of vitamin D concentrations in northern Sweden between 1986 and 2014.
KW - Cross-Sectional Studies
KW - Europe
KW - Female
KW - Humans
KW - Male
KW - Seasons
KW - Sweden/epidemiology
KW - Vitamin D
KW - Vitamin D Deficiency/epidemiology
U2 - 10.1007/s00394-019-02142-x
DO - 10.1007/s00394-019-02142-x
M3 - SCORING: Journal article
C2 - 31754783
VL - 59
SP - 3037
EP - 3044
JO - EUR J NUTR
JF - EUR J NUTR
SN - 1436-6207
IS - 7
ER -